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Genetic alterations and their therapeutic implications in epithelial ovarian cancer.
Lapke N, Chen CH, Chang TC, Chao A, Lu YJ, Lai CH, Tan KT, Chen HC, Lu HY, Chen SJ. Lapke N, et al. BMC Cancer. 2021 May 4;21(1):499. doi: 10.1186/s12885-021-08233-5. BMC Cancer. 2021. PMID: 33947352 Free PMC article.
Eligibility for targeted therapy was determined for each patient by a pathway-based approach. The analysis covered DNA repair, receptor tyrosine kinase, PI3K/AKT/MTOR, RAS/MAPK, cell cycle, and hedgehog pathways, and included 14 drug targets. ...
Eligibility for targeted therapy was determined for each patient by a pathway-based approach. The analysis covered DNA repair, receptor t
Decoding Tumor Phenotypes for ALK, ROS1, and RET Fusions in Lung Adenocarcinoma Using a Radiomics Approach.
Yoon HJ, Sohn I, Cho JH, Lee HY, Kim JH, Choi YL, Kim H, Lee G, Lee KS, Kim J. Yoon HJ, et al. Medicine (Baltimore). 2015 Oct;94(41):e1753. doi: 10.1097/MD.0000000000001753. Medicine (Baltimore). 2015. PMID: 26469915 Free PMC article.
We aimed to identify the clinicoradiologic predictors of tumors with ALK (anaplastic lymphoma kinase), ROS1 (c-ros oncogene 1), or RET (rearranged during transfection) fusions in patients with lung adenocarcinoma.A total of 539 pathologically confirmed lung adenocarcinomas …
We aimed to identify the clinicoradiologic predictors of tumors with ALK (anaplastic lymphoma kinase), ROS1 (c-ros oncogene 1), or RE …
Protection of C. elegans from anoxia by HYL-2 ceramide synthase.
Menuz V, Howell KS, Gentina S, Epstein S, Riezman I, Fornallaz-Mulhauser M, Hengartner MO, Gomez M, Riezman H, Martinou JC. Menuz V, et al. Science. 2009 Apr 17;324(5925):381-4. doi: 10.1126/science.1168532. Science. 2009. PMID: 19372430
In contrast to hyl-2(lf) mutants, hyl-1(lf) mutants are more resistant to anoxia than normal animals. HYL-1 and HYL-2 have complementary specificities for fatty acyl chains. ...
In contrast to hyl-2(lf) mutants, hyl-1(lf) mutants are more resistant to anoxia than normal animals. HYL-1 and HYL
Virulence determinants in vancomycin-resistant Enterococcus faecium vanB: clonal distribution, prevalence and significance of esp and hyl in Australian patients with haematological disorders.
Worth LJ, Slavin MA, Vankerckhoven V, Goossens H, Grabsch EA, Thursky KA. Worth LJ, et al. J Hosp Infect. 2008 Feb;68(2):137-44. doi: 10.1016/j.jhin.2007.10.017. J Hosp Infect. 2008. PMID: 18079021
A multiplex polymerase chain reaction was used to amplify potential virulence genes (asa1, gel E, cylA, esp and hyl) in VREfm isolates obtained from an Australian population of haematology patients. ...When compared to European and US reports, a high esp gene prevalence an …
A multiplex polymerase chain reaction was used to amplify potential virulence genes (asa1, gel E, cylA, esp and hyl) in VREfm isolate …
Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets.
Hirao A, Hamaguchi I, Suda T, Yamaguchi N. Hirao A, et al. EMBO J. 1997 May 1;16(9):2342-51. doi: 10.1093/emboj/16.9.2342. EMBO J. 1997. PMID: 9171348 Free PMC article.
Chk/Hyl is a recently isolated non-receptor tyrosine kinase with greatest homology to a ubiquitous negative regulator of Src family kinases, Csk. ...This activation was accompanied by dephosphorylation of Lyn at its C-terminal negative regulatory ty
Chk/Hyl is a recently isolated non-receptor tyrosine kinase with greatest homology to a ubiquitous negative regulator o …
The Csk-like proteins Lsk, Hyl, and Matk represent the same Csk homologous kinase (Chk) and are regulated by stem cell factor in the megakaryoblastic cell line MO7e.
Grgurevich S, Linnekin D, Musso T, Zhang X, Modi W, Varesio L, Ruscetti FW, Ortaldo JR, McVicar DW. Grgurevich S, et al. Growth Factors. 1997;14(2-3):103-15. doi: 10.3109/08977199709021514. Growth Factors. 1997. PMID: 9255603
Recently, the cDNAs for Lsk, Matk and Hyl, three Csk-related protein tyrosine kinases, have been cloned. ...Lastly, since our studies strongly suggest that the Lsk, Hyl and Matk kinases are related and regulated distinctly from Csk, we an …
Recently, the cDNAs for Lsk, Matk and Hyl, three Csk-related protein tyrosine kinases, have been cloned. ...Last …
Analysis of CSK homologous kinase (CHK/HYL) in hematopoiesis by utilizing gene knockout mice.
Hamaguchi I, Yamaguchi N, Suda J, Iwama A, Hirao A, Hashiyama M, Aizawa S, Suda T. Hamaguchi I, et al. Biochem Biophys Res Commun. 1996 Jul 5;224(1):172-9. doi: 10.1006/bbrc.1996.1003. Biochem Biophys Res Commun. 1996. PMID: 8694808
CHK/HYL is a non-receptor tyrosine kinase that belongs to CSK (C-terminal Src kinase) family. ...Hematological observations including blood counts and FACS analysis showed no significant abnormalities in CHK/HYL mutant mice. CHK/HYL did n …
CHK/HYL is a non-receptor tyrosine kinase that belongs to CSK (C-terminal Src kinase) family. ...Hematological o …
12 results