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Page 1
Distribution, metabolism, excretion, and toxicity of implanted silver: a review.
Hadrup N, Sharma AK, Jacobsen NR, Loeschner K. Hadrup N, et al. Drug Chem Toxicol. 2022 Sep;45(5):2388-2397. doi: 10.1080/01480545.2021.1950167. Epub 2021 Aug 30. Drug Chem Toxicol. 2022. PMID: 34455878 Review.
Some implantable medical devices contain silver. We aimed to assess at what amount implanted silver becomes toxic. Silver was elevated in bodily fluids and tissues surrounding silver-containing implants. ...
Some implantable medical devices contain silver. We aimed to assess at what amount implanted silver becomes toxic. Silver
Oral toxicity of silver ions, silver nanoparticles and colloidal silver--a review.
Hadrup N, Lam HR. Hadrup N, et al. Regul Toxicol Pharmacol. 2014 Feb;68(1):1-7. doi: 10.1016/j.yrtph.2013.11.002. Epub 2013 Nov 12. Regul Toxicol Pharmacol. 2014. PMID: 24231525 Review.
Orally administered silver has been described to be absorbed in a range of 0.4-18% in mammals with a human value of 18%. ...Substantial evidence exists suggesting that the effects induced by particulate silver are mediated via silver ions that are released fr …
Orally administered silver has been described to be absorbed in a range of 0.4-18% in mammals with a human value of 18%. ...Substanti …
Pulmonary toxicity of silver vapours, nanoparticles and fine dusts: A review.
Hadrup N, Sharma AK, Loeschner K, Jacobsen NR. Hadrup N, et al. Regul Toxicol Pharmacol. 2020 Aug;115:104690. doi: 10.1016/j.yrtph.2020.104690. Epub 2020 May 28. Regul Toxicol Pharmacol. 2020. PMID: 32474071 Free article. Review.
Argyria-a blue-grey discoloration of skin due to deposited silver-was observed after pulmonary exposure in 3 individuals; however, the presence of silver in the discolorations was not tested. ...However, silver nanoparticles and ions have a similar pattern of …
Argyria-a blue-grey discoloration of skin due to deposited silver-was observed after pulmonary exposure in 3 individuals; however, th …
Toxicity of silver ions, metallic silver, and silver nanoparticle materials after in vivo dermal and mucosal surface exposure: A review.
Hadrup N, Sharma AK, Loeschner K. Hadrup N, et al. Regul Toxicol Pharmacol. 2018 Oct;98:257-267. doi: 10.1016/j.yrtph.2018.08.007. Epub 2018 Aug 17. Regul Toxicol Pharmacol. 2018. PMID: 30125612 Review.
Acute human mortality has been observed following an abortion procedure involving the intrauterine administration of 7 g silver nitrate (64 mg silver/kg body weight). Localized argyria has been reported with exposure to silver ions, metallic surfaces, and nan …
Acute human mortality has been observed following an abortion procedure involving the intrauterine administration of 7 g silver nitra …
The similar neurotoxic effects of nanoparticulate and ionic silver in vivo and in vitro.
Hadrup N, Loeschner K, Mortensen A, Sharma AK, Qvortrup K, Larsen EH, Lam HR. Hadrup N, et al. Neurotoxicology. 2012 Jun;33(3):416-23. doi: 10.1016/j.neuro.2012.04.008. Epub 2012 Apr 15. Neurotoxicology. 2012. PMID: 22531227
We compared the neurotoxic effects of 14 nm silver nanoparticles (AgNPs) and ionic silver, in the form of silver acetate (AgAc), in vivo and in vitro. ...These findings suggest that ionic silver and a 14 nm AgNP preparation have similar neurotoxic effe …
We compared the neurotoxic effects of 14 nm silver nanoparticles (AgNPs) and ionic silver, in the form of silver acetat …
Toxicity dose descriptors from animal inhalation studies of 13 nanomaterials and their bulk and ionic counterparts and variation with primary particle characteristics.
Hadrup N, Sahlgren N, Jacobsen NR, Saber AT, Hougaard KS, Vogel U, Jensen KA. Hadrup N, et al. Nanotoxicology. 2023 Jun;17(4):338-371. doi: 10.1080/17435390.2023.2221728. Epub 2023 Jun 10. Nanotoxicology. 2023. PMID: 37300873 Review.
Reviewed materials are compounds (mainly elements, oxides and salts) of carbon (carbon black, carbon nanotubes, and graphene), silver, cerium, cobalt, copper, iron, nickel, silicium (amorphous silica and quartz), titanium (titanium dioxide), and zinc (chemical symbols: Ag, …
Reviewed materials are compounds (mainly elements, oxides and salts) of carbon (carbon black, carbon nanotubes, and graphene), silver
Subacute oral toxicity investigation of nanoparticulate and ionic silver in rats.
Hadrup N, Loeschner K, Bergström A, Wilcks A, Gao X, Vogel U, Frandsen HL, Larsen EH, Lam HR, Mortensen A. Hadrup N, et al. Arch Toxicol. 2012 Apr;86(4):543-51. doi: 10.1007/s00204-011-0759-1. Epub 2011 Oct 4. Arch Toxicol. 2012. PMID: 21969074
Subacute toxicity of 14 nm nanoparticulate silver (Ag-NP) stabilised with polyvinylpyrrolidone and ionic silver in the form of silver acetate (Ag-acetate) was investigated in four-week-old Wistar rats. ...Caecal bacterial phyla and their silver resista …
Subacute toxicity of 14 nm nanoparticulate silver (Ag-NP) stabilised with polyvinylpyrrolidone and ionic silver in the form of …
Nanoparticulate silver increases uric acid and allantoin excretion in rats, as identified by metabolomics.
Hadrup N, Lam HR, Loeschner K, Mortensen A, Larsen EH, Frandsen H. Hadrup N, et al. J Appl Toxicol. 2012 Nov;32(11):929-33. doi: 10.1002/jat.2779. Epub 2012 May 18. J Appl Toxicol. 2012. PMID: 22610381
Metabolomic investigation of rat urine was employed to identify mammalian metabolites affected by ionic or nanoparticulate silver. Female and male Wistar rats were administered silver nanoparticles (2.25, 4.5 or 9.0 mg kg(-1) body weight per day) or ionic silver
Metabolomic investigation of rat urine was employed to identify mammalian metabolites affected by ionic or nanoparticulate silver. Fe …
Distribution of silver in rats following 28 days of repeated oral exposure to silver nanoparticles or silver acetate.
Loeschner K, Hadrup N, Qvortrup K, Larsen A, Gao X, Vogel U, Mortensen A, Lam HR, Larsen EH. Loeschner K, et al. Among authors: hadrup n. Part Fibre Toxicol. 2011 Jun 1;8:18. doi: 10.1186/1743-8977-8-18. Part Fibre Toxicol. 2011. PMID: 21631937 Free PMC article.
BACKGROUND: The study investigated the distribution of silver after 28 days repeated oral administration of silver nanoparticles (AgNPs) and silver acetate (AgAc) to rats. ...The presence of silver granules containing selenium and sulfur in the intesti …
BACKGROUND: The study investigated the distribution of silver after 28 days repeated oral administration of silver nanoparticl …