Hagen TJ - Search Results

1

Compound D159687, a phosphodiesterase 4D inhibitor, induces weight and fat mass loss in aged mice without changing lean mass, physical and cognitive function.

Muo IM, Park SJ, Smith A, A Springer D, Allen MD, Hagen TJ, Chung JH. Muo IM, et al. Among authors: hagen tj. Biochem Biophys Res Commun. 2018 Dec 2;506(4):1059-1064. doi: 10.1016/j.bbrc.2018.10.180. Epub 2018 Nov 6. Biochem Biophys Res Commun. 2018. PMID: 30409425 Free PMC article.

2

Discovery of triazines as selective PDE4B versus PDE4D inhibitors.

Hagen TJ, Mo X, Burgin AB, Fox D 3rd, Zhang Z, Gurney ME. Hagen TJ, et al. Bioorg Med Chem Lett. 2014 Aug 15;24(16):4031-4. doi: 10.1016/j.bmcl.2014.06.002. Epub 2014 Jun 12. Bioorg Med Chem Lett. 2014. PMID: 24998378 Free PMC article.

3

Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders.

Gurney ME, Nugent RA, Mo X, Sindac JA, Hagen TJ, Fox D 3rd, O'Donnell JM, Zhang C, Xu Y, Zhang HT, Groppi VE, Bailie M, White RE, Romero DL, Vellekoop AS, Walker JR, Surman MD, Zhu L, Campbell RF. Gurney ME, et al. Among authors: hagen tj. J Med Chem. 2019 May 23;62(10):4884-4901. doi: 10.1021/acs.jmedchem.9b00193. Epub 2019 Apr 23. J Med Chem. 2019. PMID: 31013090 Free PMC article.

4

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.

Burgin AB, Magnusson OT, Singh J, Witte P, Staker BL, Bjornsson JM, Thorsteinsdottir M, Hrafnsdottir S, Hagen T, Kiselyov AS, Stewart LJ, Gurney ME. Burgin AB, et al. Nat Biotechnol. 2010 Jan;28(1):63-70. doi: 10.1038/nbt.1598. Epub 2009 Dec 27. Nat Biotechnol. 2010. PMID: 20037581

5

Discovery of Inhibitors of Burkholderia pseudomallei Methionine Aminopeptidase with Antibacterial Activity.

Wangtrakuldee P, Byrd MS, Campos CG, Henderson MW, Zhang Z, Clare M, Masoudi A, Myler PJ, Horn JR, Cotter PA, Hagen TJ. Wangtrakuldee P, et al. Among authors: hagen tj. ACS Med Chem Lett. 2013 Jul 1;4(8):699-703. doi: 10.1021/ml400034m. ACS Med Chem Lett. 2013. PMID: 24376907 Free PMC article.

6

The synthesis, antimalarial activity and CoMFA analysis of novel aminoalkylated quercetin analogs.

Helgren TR, Sciotti RJ, Lee P, Duffy S, Avery VM, Igbinoba O, Akoto M, Hagen TJ. Helgren TR, et al. Among authors: hagen tj. Bioorg Med Chem Lett. 2015 Jan 15;25(2):327-32. doi: 10.1016/j.bmcl.2014.11.039. Epub 2014 Nov 21. Bioorg Med Chem Lett. 2015. PMID: 25488841

7

Synthesis and biological evaluation of pyrazolopyrimidines as potential antibacterial agents.

Goshu GM, Ghose D, Bain JM, Pierce PG, Begley DW, Hewitt SN, Udell HS, Myler PJ, Meganathan R, Hagen TJ. Goshu GM, et al. Among authors: hagen tj. Bioorg Med Chem Lett. 2015 Dec 15;25(24):5699-704. doi: 10.1016/j.bmcl.2015.10.096. Bioorg Med Chem Lett. 2015. PMID: 26584881 Free PMC article.

8

Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents.

Helgren TR, Chen C, Wangtrakuldee P, Edwards TE, Staker BL, Abendroth J, Sankaran B, Housley NA, Myler PJ, Audia JP, Horn JR, Hagen TJ. Helgren TR, et al. Among authors: hagen tj. Bioorg Med Chem. 2017 Feb 1;25(3):813-824. doi: 10.1016/j.bmc.2016.11.013. Epub 2016 Nov 10. Bioorg Med Chem. 2017. PMID: 28089350 Free PMC article.

9

Structural and biophysical characterization of the Burkholderia pseudomallei IspF inhibitor L-tryptophan hydroxamate.

Blain JM, Grote DL, Watkins SM, Goshu GM, Muller C, Gorman JL, Ranieri G, Walter RL, Hofstetter H, Horn JR, Hagen TJ. Blain JM, et al. Among authors: hagen tj. Bioorg Med Chem Lett. 2021 Sep 15;48:128273. doi: 10.1016/j.bmcl.2021.128273. Epub 2021 Jul 21. Bioorg Med Chem Lett. 2021. PMID: 34298132 Free PMC article.

10

Structural Characterization of the Reaction and Substrate Specificity Mechanisms of Pathogenic Fungal Acetyl-CoA Synthetases.

Jezewski AJ, Alden KM, Esan TE, DeBouver ND, Abendroth J, Bullen JC, Calhoun BM, Potts KT, Murante DM, Hagen TJ, Fox D, Krysan DJ. Jezewski AJ, et al. Among authors: hagen tj. ACS Chem Biol. 2021 Aug 20;16(8):1587-1599. doi: 10.1021/acschembio.1c00484. Epub 2021 Aug 9. ACS Chem Biol. 2021. PMID: 34369755 Free PMC article.

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