Haigis M - Search Results

1

Calorie restriction extends yeast life span by lowering the level of NADH.

Lin SJ, Ford E, Haigis M, Liszt G, Guarente L. Lin SJ, et al. Among authors: haigis m. Genes Dev. 2004 Jan 1;18(1):12-6. doi: 10.1101/gad.1164804. Genes Dev. 2004. PMID: 14724176 Free PMC article.

2

Superoxide dismutase 1 knock-down induces senescence in human fibroblasts.

Blander G, de Oliveira RM, Conboy CM, Haigis M, Guarente L. Blander G, et al. Among authors: haigis m. J Biol Chem. 2003 Oct 3;278(40):38966-9. doi: 10.1074/jbc.M307146200. Epub 2003 Jul 18. J Biol Chem. 2003. PMID: 12871978 Free article.

3

Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria.

Leissring MA, Farris W, Wu X, Christodoulou DC, Haigis MC, Guarente L, Selkoe DJ. Leissring MA, et al. Biochem J. 2004 Nov 1;383(Pt. 3):439-46. doi: 10.1042/BJ20041081. Biochem J. 2004. PMID: 15285718 Free PMC article.

4

SIRT1 shows no substrate specificity in vitro.

Blander G, Olejnik J, Krzymanska-Olejnik E, McDonagh T, Haigis M, Yaffe MB, Guarente L. Blander G, et al. Among authors: haigis m. J Biol Chem. 2005 Mar 18;280(11):9780-5. doi: 10.1074/jbc.M414080200. Epub 2005 Jan 6. J Biol Chem. 2005. PMID: 15640142 Free article.

5

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.

Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L. Haigis MC, et al. Among authors: haigis km. Cell. 2006 Sep 8;126(5):941-54. doi: 10.1016/j.cell.2006.06.057. Cell. 2006. PMID: 16959573 Free article.

6

Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction.

Haigis MC, Guarente LP. Haigis MC, et al. Genes Dev. 2006 Nov 1;20(21):2913-21. doi: 10.1101/gad.1467506. Genes Dev. 2006. PMID: 17079682 Free article. Review.

7

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.

Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV Jr, Weissman S, Verdin E, Schwer B. Lombard DB, et al. Among authors: haigis m. Mol Cell Biol. 2007 Dec;27(24):8807-14. doi: 10.1128/MCB.01636-07. Epub 2007 Oct 8. Mol Cell Biol. 2007. PMID: 17923681 Free PMC article.

8

SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle.

Nakagawa T, Lomb DJ, Haigis MC, Guarente L. Nakagawa T, et al. Cell. 2009 May 1;137(3):560-70. doi: 10.1016/j.cell.2009.02.026. Cell. 2009. PMID: 19410549 Free PMC article.

9

REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors.

Qiao S, Koh SB, Vivekanandan V, Salunke D, Patra KC, Zaganjor E, Ross K, Mizukami Y, Jeanfavre S, Chen A, Mino-Kenudson M, Ramaswamy S, Clish C, Haigis M, Bardeesy N, Ellisen LW. Qiao S, et al. Among authors: haigis m. Genes Dev. 2020 Jun 1;34(11-12):751-766. doi: 10.1101/gad.335166.119. Epub 2020 Apr 9. Genes Dev. 2020. PMID: 32273287 Free PMC article.

10

Pancreatic cancers require autophagy for tumor growth.

Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, Bardeesy N, Kimmelman AC. Yang S, et al. Among authors: haigis m. Genes Dev. 2011 Apr 1;25(7):717-29. doi: 10.1101/gad.2016111. Epub 2011 Mar 15. Genes Dev. 2011. PMID: 21406549 Free PMC article.

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