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Discovery of STRO-002, a Novel Homogeneous ADC Targeting Folate Receptor Alpha, for the Treatment of Ovarian and Endometrial Cancers.
Li X, Zhou S, Abrahams CL, Krimm S, Smith J, Bajjuri K, Stephenson HT, Henningsen R, Hanson J, Heibeck TH, Calarese D, Tran C, Yin G, Stafford RL, Yam AY, Kline T, De Almeida VI, Sato AK, Lupher M, Bedard K, Hallam TJ. Li X, et al. Among authors: hallam tj. Mol Cancer Ther. 2023 Feb 1;22(2):155-167. doi: 10.1158/1535-7163.MCT-22-0322. Mol Cancer Ther. 2023. PMID: 36459691 Free PMC article.
Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system.
Zimmerman ES, Heibeck TH, Gill A, Li X, Murray CJ, Madlansacay MR, Tran C, Uter NT, Yin G, Rivers PJ, Yam AY, Wang WD, Steiner AR, Bajad SU, Penta K, Yang W, Hallam TJ, Thanos CD, Sato AK. Zimmerman ES, et al. Among authors: hallam tj. Bioconjug Chem. 2014 Feb 19;25(2):351-61. doi: 10.1021/bc400490z. Epub 2014 Jan 29. Bioconjug Chem. 2014. PMID: 24437342
In vitro Fab display: a cell-free system for IgG discovery.
Stafford RL, Matsumoto ML, Yin G, Cai Q, Fung JJ, Stephenson H, Gill A, You M, Lin SH, Wang WD, Masikat MR, Li X, Penta K, Steiner AR, Baliga R, Murray CJ, Thanos CD, Hallam TJ, Sato AK. Stafford RL, et al. Among authors: hallam tj. Protein Eng Des Sel. 2014 Apr;27(4):97-109. doi: 10.1093/protein/gzu002. Epub 2014 Feb 28. Protein Eng Des Sel. 2014. PMID: 24586053 Free PMC article.
Methods to Make Homogenous Antibody Drug Conjugates.
Kline T, Steiner AR, Penta K, Sato AK, Hallam TJ, Yin G. Kline T, et al. Among authors: hallam tj. Pharm Res. 2015 Nov;32(11):3480-93. doi: 10.1007/s11095-014-1596-8. Epub 2014 Dec 16. Pharm Res. 2015. PMID: 25511917 Free PMC article. Review.
RF1 attenuation enables efficient non-natural amino acid incorporation for production of homogeneous antibody drug conjugates.
Yin G, Stephenson HT, Yang J, Li X, Armstrong SM, Heibeck TH, Tran C, Masikat MR, Zhou S, Stafford RL, Yam AY, Lee J, Steiner AR, Gill A, Penta K, Pollitt S, Baliga R, Murray CJ, Thanos CD, McEvoy LM, Sato AK, Hallam TJ. Yin G, et al. Among authors: hallam tj. Sci Rep. 2017 Jun 8;7(1):3026. doi: 10.1038/s41598-017-03192-z. Sci Rep. 2017. PMID: 28596531 Free PMC article.
Post-Exposure Protection in Mice against Sudan Virus by a Two Antibody Cocktail.
Froude JW, Herbert AS, Pelat T, Miethe S, Zak SE, Brannan JM, Bakken RR, Steiner AR, Yin G, Hallam TJ, Sato AK, Hust M, Thullier P, Dye JM. Froude JW, et al. Among authors: hallam tj. Viruses. 2018 May 26;10(6):286. doi: 10.3390/v10060286. Viruses. 2018. PMID: 29861435 Free PMC article.
71 results