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β₁-adrenergic receptor-mediated HO-1 induction, via PI3K and p38 MAPK, by isoproterenol in RAW 264.7 cells leads to inhibition of HMGB1 release in LPS-activated RAW 264.7 cells and increases in survival rate of CLP-induced septic mice.
Ha YM, Ham SA, Kim YM, Lee YS, Kim HJ, Seo HG, Lee JH, Park MK, Chang KC. Ha YM, et al. Among authors: ham sa. Biochem Pharmacol. 2011 Oct 1;82(7):769-77. doi: 10.1016/j.bcp.2011.06.041. Epub 2011 Jul 5. Biochem Pharmacol. 2011. PMID: 21763292
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