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33 results

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Page 1
Mendelian Randomization Using the Druggable Genome Reveals Genetically Supported Drug Targets for Psychiatric Disorders.
Li X, Shen A, Zhao Y, Xia J. Li X, et al. Schizophr Bull. 2023 Sep 7;49(5):1305-1315. doi: 10.1093/schbul/sbad100. Schizophr Bull. 2023. PMID: 37418754 Free PMC article.
Combining MR results using pQTL genetic instruments, we finally proposed 8 drug-targeting genes supported by the strongest MR evidence, including gene ACE, BTN3A3, HAPLN4, MAPK3 and NEK4 for schizophrenia, gene NEK4 and HAPLN4 for bipolar disorder, and gene TIE1 for …
Combining MR results using pQTL genetic instruments, we finally proposed 8 drug-targeting genes supported by the strongest MR evidence, incl …
Hapln4/Bral2 is a selective regulator for formation and transmission of GABAergic synapses between Purkinje and deep cerebellar nuclei neurons.
Edamatsu M, Miyano R, Fujikawa A, Fujii F, Hori T, Sakaba T, Oohashi T. Edamatsu M, et al. J Neurochem. 2018 Dec;147(6):748-763. doi: 10.1111/jnc.14571. Epub 2018 Nov 11. J Neurochem. 2018. PMID: 30125937 Free article.
Here, using immunohistochemistry we show that Hapln4/Bral2 localized closely with GABAergic terminals. In DCN neurons of Hapln4/Bral2 KO mice, inhibitory synaptic strengths were reduced as compared to those in wild-type mice, whereas the properties of excitatory syn …
Here, using immunohistochemistry we show that Hapln4/Bral2 localized closely with GABAergic terminals. In DCN neurons of Hapln4 …
The Effect of Hapln4 Link Protein Deficiency on Extracellular Space Diffusion Parameters and Perineuronal Nets in the Auditory System During Aging.
Sucha P, Chmelova M, Kamenicka M, Bochin M, Oohashi T, Vargova L. Sucha P, et al. Neurochem Res. 2020 Jan;45(1):68-82. doi: 10.1007/s11064-019-02894-2. Epub 2019 Oct 29. Neurochem Res. 2020. PMID: 31664654
Hapln4 is a link protein which stabilizes the binding between lecticans and hyaluronan in perineuronal nets (PNNs) in specific brain regions, including the medial nucleus of the trapezoid body (MNTB). The aim of this study was: (1) to reveal possible age-related alteration …
Hapln4 is a link protein which stabilizes the binding between lecticans and hyaluronan in perineuronal nets (PNNs) in specific brain …
Genomic Markers for Essential Tremor.
Jiménez-Jiménez FJ, Alonso-Navarro H, García-Martín E, Álvarez I, Pastor P, Agúndez JAG. Jiménez-Jiménez FJ, et al. Pharmaceuticals (Basel). 2021 May 27;14(6):516. doi: 10.3390/ph14060516. Pharmaceuticals (Basel). 2021. PMID: 34072005 Free PMC article. Review.
Exome studies described the association of several genes with familial ET (FUS, HTRA2, TENM4, SORT1, SCN11A, NOTCH2NLC, NOS3, KCNS2, HAPLN4, USP46, CACNA1G, SLIT3, CCDC183, MMP10, and GPR151), but they were found only in singular families and, again, not found in other fam …
Exome studies described the association of several genes with familial ET (FUS, HTRA2, TENM4, SORT1, SCN11A, NOTCH2NLC, NOS3, KCNS2, HAPL …
MiR-19b alleviates MPP(+)-induced neuronal cytotoxicity via targeting the HAPLN4/MAPK pathway in SH-SY5Y cells.
Liu W, Geng L, Chen Y. Liu W, et al. RSC Adv. 2018 Mar 16;8(19):10706-10714. doi: 10.1039/c7ra13406a. eCollection 2018 Mar 13. RSC Adv. 2018. PMID: 35540477 Free PMC article.
RT-qPCR was performed to detect the expression of miR-19b and proteoglycan link protein 4 (HAPLN4) mRNA. Western blot analysis was used to measure the level of HAPLN4 and mitogen activated protein kinase (MAPK)-related protein. ...Conclusion: the neuroprotective eff …
RT-qPCR was performed to detect the expression of miR-19b and proteoglycan link protein 4 (HAPLN4) mRNA. Western blot analysis was us …
A view of the genetic and proteomic profile of extracellular matrix molecules in aging and stroke.
Chmelova M, Androvic P, Kirdajova D, Tureckova J, Kriska J, Valihrach L, Anderova M, Vargova L. Chmelova M, et al. Front Cell Neurosci. 2023 Nov 30;17:1296455. doi: 10.3389/fncel.2023.1296455. eCollection 2023. Front Cell Neurosci. 2023. PMID: 38107409 Free PMC article.
Ischemia evoked a significant downregulation in only 6 of our genes of interest, including those encoding proteins associated with the protective function of ECM molecules (e.g., brevican, Hapln4, Sparcl1); downregulation in brevican was more prominent in aged mice. The st …
Ischemia evoked a significant downregulation in only 6 of our genes of interest, including those encoding proteins associated with the prote …
Genomic regulatory sequences in the pathogenesis of bipolar disorder.
Levchenko A, Plotnikova M. Levchenko A, et al. Front Psychiatry. 2023 Feb 7;14:1115924. doi: 10.3389/fpsyt.2023.1115924. eCollection 2023. Front Psychiatry. 2023. PMID: 36824672 Free PMC article. Review.
In the light of these discoveries, the Mini Review focuses on the genes PACS1, MCHR1, DCLK3, HAPLN4, LMAN2L, TMEM258, GNL3, LRRC57, CACNA1C, CACNA1D, and NOVA2 and their potential biological role in the pathogenesis of bipolar disorder. ...
In the light of these discoveries, the Mini Review focuses on the genes PACS1, MCHR1, DCLK3, HAPLN4, LMAN2L, TMEM258, GNL3, LRRC57, C …
Linking epileptic phenotypes and neural extracellular matrix remodeling signatures in mouse models of epilepsy.
Blondiaux A, Jia S, Annamneedi A, Çalışkan G, Nebel J, Montenegro-Venegas C, Wykes RC, Fejtova A, Walker MC, Stork O, Gundelfinger ED, Dityatev A, Seidenbecher CI. Blondiaux A, et al. Neurobiol Dis. 2023 Nov;188:106324. doi: 10.1016/j.nbd.2023.106324. Epub 2023 Oct 12. Neurobiol Dis. 2023. PMID: 37838005 Free article.
Strikingly, Brevican, Neurocan, Aggrecan and link proteins Hapln1 and Hapln4 levels reliably predicted seizure properties across models, suggesting a link between ECM state and epileptic phenotype....
Strikingly, Brevican, Neurocan, Aggrecan and link proteins Hapln1 and Hapln4 levels reliably predicted seizure properties across mode …
Uncovering Essential Tremor Genetics: The Promise of Long-Read Sequencing.
Marsili L, Duque KR, Bode RL, Kauffman MA, Espay AJ. Marsili L, et al. Front Neurol. 2022 Mar 23;13:821189. doi: 10.3389/fneur.2022.821189. eCollection 2022. Front Neurol. 2022. PMID: 35401394 Free PMC article. Review.
Exome sequencing has revealed the genetic etiology only in rare ET families (FUS, SORT1, SCN4A, NOS3, KCNS2, HAPLN4/BRAL2, and USP46). We hypothesize that a reason for this shortcoming may be non-classical genetic mechanism(s) underpinning ET, among them trinucleotide, tet …
Exome sequencing has revealed the genetic etiology only in rare ET families (FUS, SORT1, SCN4A, NOS3, KCNS2, HAPLN4/BRAL2, and USP46) …
Chronic adolescent exposure to cannabis in mice leads to sex-biased changes in gene expression networks across brain regions.
Zuo Y, Iemolo A, Montilla-Perez P, Li HR, Yang X, Telese F. Zuo Y, et al. Neuropsychopharmacology. 2022 Nov;47(12):2071-2080. doi: 10.1038/s41386-022-01413-2. Epub 2022 Aug 22. Neuropsychopharmacology. 2022. PMID: 35995972 Free PMC article.
This analysis revealed a common regulatory mechanism linked to CUD vulnerability in the nucleus accumbens of females and males, which shared four key drivers (Hapln4, Kcnc1, Elavl2, Zcchc12). These genes regulate transcriptional subnetworks implicated in addiction processe …
This analysis revealed a common regulatory mechanism linked to CUD vulnerability in the nucleus accumbens of females and males, which shared …
33 results