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Activation of Ran GTPase by a Legionella effector promotes microtubule polymerization, pathogen vacuole motility and infection.
Rothmeier E, Pfaffinger G, Hoffmann C, Harrison CF, Grabmayr H, Repnik U, Hannemann M, Wölke S, Bausch A, Griffiths G, Müller-Taubenberger A, Itzen A, Hilbi H. Rothmeier E, et al. Among authors: harrison cf. PLoS Pathog. 2013 Sep;9(9):e1003598. doi: 10.1371/journal.ppat.1003598. Epub 2013 Sep 19. PLoS Pathog. 2013. PMID: 24068924 Free PMC article.
Exploring anti-bacterial compounds against intracellular Legionella.
Harrison CF, Kicka S, Trofimov V, Berschl K, Ouertatani-Sakouhi H, Ackermann N, Hedberg C, Cosson P, Soldati T, Hilbi H. Harrison CF, et al. PLoS One. 2013 Sep 13;8(9):e74813. doi: 10.1371/journal.pone.0074813. eCollection 2013. PLoS One. 2013. PMID: 24058631 Free PMC article.
Adrenergic antagonists restrict replication of Legionella.
Harrison CF, Kicka S, Kranjc A, Finsel I, Chiriano G, Ouertatani-Sakouhi H, Soldati T, Scapozza L, Hilbi H. Harrison CF, et al. Microbiology (Reading). 2015 Jul;161(7):1392-406. doi: 10.1099/mic.0.000094. Epub 2015 Apr 14. Microbiology (Reading). 2015. PMID: 25873585 Free article.
In Silico Driven Design and Synthesis of Rhodanine Derivatives as Novel Antibacterials Targeting the Enoyl Reductase InhA.
Slepikas L, Chiriano G, Perozzo R, Tardy S, Kranjc A, Patthey-Vuadens O, Ouertatani-Sakouhi H, Kicka S, Harrison CF, Scrignari T, Perron K, Hilbi H, Soldati T, Cosson P, Tarasevicius E, Scapozza L. Slepikas L, et al. Among authors: harrison cf. J Med Chem. 2016 Dec 22;59(24):10917-10928. doi: 10.1021/acs.jmedchem.5b01620. Epub 2016 Dec 9. J Med Chem. 2016. PMID: 26730986
21 results