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The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's active metabolite.
Sugidachi A, Ogawa T, Kurihara A, Hagihara K, Jakubowski JA, Hashimoto M, Niitsu Y, Asai F. Sugidachi A, et al. Among authors: hashimoto m. J Thromb Haemost. 2007 Jul;5(7):1545-51. doi: 10.1111/j.1538-7836.2007.02598.x. Epub 2007 Apr 19. J Thromb Haemost. 2007. PMID: 17456192 Free article.
Discovery of DS79182026: A potent orally active hepcidin production inhibitor.
Fukuda T, Goto R, Kiho T, Ueda K, Muramatsu S, Hashimoto M, Aki A, Watanabe K, Tanaka N. Fukuda T, et al. Among authors: hashimoto m. Bioorg Med Chem Lett. 2017 Aug 15;27(16):3716-3722. doi: 10.1016/j.bmcl.2017.07.004. Epub 2017 Jul 3. Bioorg Med Chem Lett. 2017. PMID: 28705644
4,558 results