Havenaar R - Search Results

1

On the usefulness of compendial setups and tiny-TIM system in evaluating the in vivo performance of oral drug products with various release profiles in the fasted state: Case example sodium salt of A6197.

Schilderink R, Protopappa M, Fleth-James J, Vertzoni M, Schaefer K, Havenaar R, Kulla I, Metzger M, Reppas C. Schilderink R, et al. Among authors: havenaar r. Eur J Pharm Biopharm. 2020 Apr;149:154-162. doi: 10.1016/j.ejpb.2020.02.003. Epub 2020 Feb 11. Eur J Pharm Biopharm. 2020. PMID: 32057905 Clinical Trial.

2

Evaluation of two dynamic in vitro models simulating fasted and fed state conditions in the upper gastrointestinal tract (TIM-1 and tiny-TIM) for investigating the bioaccessibility of pharmaceutical compounds from oral dosage forms.

Verwei M, Minekus M, Zeijdner E, Schilderink R, Havenaar R. Verwei M, et al. Among authors: havenaar r. Int J Pharm. 2016 Feb 10;498(1-2):178-86. doi: 10.1016/j.ijpharm.2015.11.048. Epub 2015 Dec 11. Int J Pharm. 2016. PMID: 26688035

3

In vitro gastrointestinal model (TIM) with predictive power, even for infants and children?

Havenaar R, Anneveld B, Hanff LM, de Wildt SN, de Koning BA, Mooij MG, Lelieveld JP, Minekus M. Havenaar R, et al. Int J Pharm. 2013 Nov 30;457(1):327-32. doi: 10.1016/j.ijpharm.2013.07.053. Epub 2013 Jul 29. Int J Pharm. 2013. PMID: 23906665 Clinical Trial.

4

Increased bioavailability of celecoxib under fed versus fasted conditions is determined by postprandial bile secretion as demonstrated in a dynamic gastrointestinal model.

Lyng E, Havenaar R, Shastri P, Hetsco L, Vick A, Sagartz J. Lyng E, et al. Among authors: havenaar r. Drug Dev Ind Pharm. 2016 Aug;42(8):1334-9. doi: 10.3109/03639045.2015.1135935. Epub 2016 Feb 18. Drug Dev Ind Pharm. 2016. PMID: 26755336

5

Folic acid and 5-methyltetrahydrofolate in fortified milk are bioaccessible as determined in a dynamic in vitro gastrointestinal model.

Verwei M, Arkbåge K, Havenaar R, van den Berg H, Witthöft C, Schaafsma G. Verwei M, et al. Among authors: havenaar r. J Nutr. 2003 Jul;133(7):2377-83. doi: 10.1093/jn/133.7.2377. J Nutr. 2003. PMID: 12840209

6

Predicted serum folate concentrations based on in vitro studies and kinetic modeling are consistent with measured folate concentrations in humans.

Verwei M, Freidig AP, Havenaar R, Groten JP. Verwei M, et al. Among authors: havenaar r. J Nutr. 2006 Dec;136(12):3074-8. doi: 10.1093/jn/136.12.3074. J Nutr. 2006. PMID: 17116722 Free article.

7

Appetite ratings of foods are predictable with an in vitro advanced gastrointestinal model in combination with an in silico artificial neural network.

Bellmann S, Krishnan S, de Graaf A, de Ligt RA, Pasman WJ, Minekus M, Havenaar R. Bellmann S, et al. Among authors: havenaar r. Food Res Int. 2019 Aug;122:77-86. doi: 10.1016/j.foodres.2019.03.051. Epub 2019 Mar 25. Food Res Int. 2019. PMID: 31229132

8

The binding of folic acid and 5-methyltetrahydrofolate to folate-binding proteins during gastric passage differs in a dynamic in vitro gastrointestinal model.

Verwei M, Arkbåge K, Mocking H, Havenaar R, Groten J. Verwei M, et al. Among authors: havenaar r. J Nutr. 2004 Jan;134(1):31-7. doi: 10.1093/jn/134.1.31. J Nutr. 2004. PMID: 14704289 Free article.

9

A dynamic artificial gastrointestinal system for studying the behavior of orally administered drug dosage forms under various physiological conditions.

Blanquet S, Zeijdner E, Beyssac E, Meunier JP, Denis S, Havenaar R, Alric M. Blanquet S, et al. Among authors: havenaar r. Pharm Res. 2004 Apr;21(4):585-91. doi: 10.1023/b:pham.0000022404.70478.4b. Pharm Res. 2004. PMID: 15139514

10

Description of a dynamic in vitro model of the dog gastrointestinal tract and an evaluation of various transit times for protein and calcium.

Smeets-Peeters MJ, Minekus M, Havenaar R, Schaafsma G, Verstegen MW. Smeets-Peeters MJ, et al. Among authors: havenaar r. Altern Lab Anim. 1999 Nov-Dec;27(6):935-49. doi: 10.1177/026119299902700608. Altern Lab Anim. 1999. PMID: 25490462

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