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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1926 1
1932 1
1936 1
1937 1
1941 1
1966 5
1971 2
1973 1
1974 3
1975 1
1976 3
1977 3
1978 6
1979 2
1980 3
1981 5
1982 5
1983 3
1984 3
1985 3
1986 10
1987 33
1988 64
1989 81
1990 91
1991 103
1992 108
1993 103
1994 81
1995 110
1996 105
1997 120
1998 122
1999 115
2000 110
2001 133
2002 122
2003 151
2004 134
2005 175
2006 187
2007 165
2008 190
2009 184
2010 197
2011 259
2012 285
2013 290
2014 487
2015 609
2016 710
2017 773
2018 887
2019 968
2020 1139
2021 1273
2022 1327
2023 1255
2024 605

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12,138 results

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Page 1
Cellular and Molecular Mechanisms of Metformin Action.
LaMoia TE, Shulman GI. LaMoia TE, et al. Endocr Rev. 2021 Jan 28;42(1):77-96. doi: 10.1210/endrev/bnaa023. Endocr Rev. 2021. PMID: 32897388 Free PMC article. Review.
Metformin is a first-line therapy for the treatment of type 2 diabetes, due to its robust glucose-lowering effects, well-established safety profile, and relatively low cost. While metformin has been shown to have pleotropic effects on glucose metabolism, there is a general …
Metformin is a first-line therapy for the treatment of type 2 diabetes, due to its robust glucose-lowering effects, well-established …
Metformin in 2019.
Flory J, Lipska K. Flory J, et al. JAMA. 2019 May 21;321(19):1926-1927. doi: 10.1001/jama.2019.3805. JAMA. 2019. PMID: 31009043 Free PMC article. Review.
Metformin is the first-line pharmacologic treatment for type 2 diabetes and the most commonly prescribed drug for this condition worldwide, either alone or in combination with insulin or other glucose-lowering therapies. Metformin is a biguanide, a drug class of herbal ori …
Metformin is the first-line pharmacologic treatment for type 2 diabetes and the most commonly prescribed drug for this condition worldwide, …
Lipoprotein(a) and its Significance in Cardiovascular Disease: A Review.
Duarte Lau F, Giugliano RP. Duarte Lau F, et al. JAMA Cardiol. 2022 Jul 1;7(7):760-769. doi: 10.1001/jamacardio.2022.0987. JAMA Cardiol. 2022. PMID: 35583875 Review.
These findings have led to the formulation of the Lp(a) hypothesis, namely that Lp(a) lowering leads to cardiovascular risk reduction, intensifying the search for Lp(a)-reducing therapies. ...Nevertheless, emerging nucleic acid-based therapies, such as the antisense oligon …
These findings have led to the formulation of the Lp(a) hypothesis, namely that Lp(a) lowering leads to cardiovascular risk reduction …
Metformin: clinical use in type 2 diabetes.
Sanchez-Rangel E, Inzucchi SE. Sanchez-Rangel E, et al. Diabetologia. 2017 Sep;60(9):1586-1593. doi: 10.1007/s00125-017-4336-x. Epub 2017 Aug 2. Diabetologia. 2017. PMID: 28770321 Review.
Metformin is one of the most popular oral glucose-lowering medications, widely considered to be the optimal initial therapy for patients with type 2 diabetes mellitus. ...With no long-term studies comparing it against newer glucose-lowering drugs, some of which have …
Metformin is one of the most popular oral glucose-lowering medications, widely considered to be the optimal initial therapy for patie …
Radiation Pneumonitis.
Bledsoe TJ, Nath SK, Decker RH. Bledsoe TJ, et al. Clin Chest Med. 2017 Jun;38(2):201-208. doi: 10.1016/j.ccm.2016.12.004. Epub 2017 Mar 1. Clin Chest Med. 2017. PMID: 28477633 Review.
Improvements in radiation technique, as well as the understanding of the pathophysiology of radiation injury, have led to lower rates of pneumonitis and improved symptom control. Here, the authors provide an overview of the pathophysiology, diagnosis, and management of pat …
Improvements in radiation technique, as well as the understanding of the pathophysiology of radiation injury, have led to lower rates …
Update on gout management: what is old and what is new.
Afinogenova Y, Danve A, Neogi T. Afinogenova Y, et al. Curr Opin Rheumatol. 2022 Mar 1;34(2):118-124. doi: 10.1097/BOR.0000000000000861. Curr Opin Rheumatol. 2022. PMID: 34907116 Free PMC article. Review.
The 2020 American College of Rheumatology gout guideline offers comprehensive evidence-based recommendations for the management of hyperuricemia using urate-lowering therapy, prophylaxis when initiating urate-lowering therapy, treatment of gout flare and adjunctive …
The 2020 American College of Rheumatology gout guideline offers comprehensive evidence-based recommendations for the management of hyperuric …
Glaucoma.
Dietze J, Blair K, Zeppieri M, Havens SJ. Dietze J, et al. 2024 Mar 16. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2024 Mar 16. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30855805 Free Books & Documents.
Although the available treatments cannot cure existing optic nerve damage or reverse visual field loss, they can help control the disease progression through medication, laser treatment, or incisional glaucoma surgeries to prevent further vision loss. All therapeutic intervention …
Although the available treatments cannot cure existing optic nerve damage or reverse visual field loss, they can help control the disease pr …
Hepatic Encephalopathy: Diagnosis and Management.
Ridola L, Faccioli J, Nardelli S, Gioia S, Riggio O. Ridola L, et al. J Transl Int Med. 2020 Dec 31;8(4):210-219. doi: 10.2478/jtim-2020-0034. eCollection 2020 Dec. J Transl Int Med. 2020. PMID: 33511048 Free PMC article. Review.
Unlike MHE, clinical examination and clinical decision are crucial for OHE diagnosis and West Haven criteria are widely used to assess the severity of neurological dysfunction. ...Treatment of OHE is based on the identification and correction of precipitating factors and s …
Unlike MHE, clinical examination and clinical decision are crucial for OHE diagnosis and West Haven criteria are widely used to asses …
Association between physical exercise and mental health in 1·2 million individuals in the USA between 2011 and 2015: a cross-sectional study.
Chekroud SR, Gueorguieva R, Zheutlin AB, Paulus M, Krumholz HM, Krystal JH, Chekroud AM. Chekroud SR, et al. Lancet Psychiatry. 2018 Sep;5(9):739-746. doi: 10.1016/S2215-0366(18)30227-X. Epub 2018 Aug 8. Lancet Psychiatry. 2018. PMID: 30099000
FINDINGS: Individuals who exercised had 1.49 (43.2%) fewer days of poor mental health in the past month than individuals who did not exercise but were otherwise matched for several physical and sociodemographic characteristics (W=7.42 10(10), p<2.2 10(-16)). All exercise types …
FINDINGS: Individuals who exercised had 1.49 (43.2%) fewer days of poor mental health in the past month than individuals who did not exercis …
Caloric restriction in humans reveals immunometabolic regulators of health span.
Spadaro O, Youm Y, Shchukina I, Ryu S, Sidorov S, Ravussin A, Nguyen K, Aladyeva E, Predeus AN, Smith SR, Ravussin E, Galban C, Artyomov MN, Dixit VD. Spadaro O, et al. Science. 2022 Feb 11;375(6581):671-677. doi: 10.1126/science.abg7292. Epub 2022 Feb 10. Science. 2022. PMID: 35143297 Free PMC article.
Deletion of Pla2g7 in mice showed decreased thymic lipoatrophy, protection against age-related inflammation, lowered NLRP3 inflammasome activation, and improved metabolic health. Therefore, the reduction of PLA2G7 may mediate the immunometabolic effects of CR and could pot …
Deletion of Pla2g7 in mice showed decreased thymic lipoatrophy, protection against age-related inflammation, lowered NLRP3 inflammaso …
12,138 results
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