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The Mycobacterium tuberculosis iniA gene is essential for activity of an efflux pump that confers drug tolerance to both isoniazid and ethambutol.
Colangeli R, Helb D, Sridharan S, Sun J, Varma-Basil M, Hazbón MH, Harbacheuski R, Megjugorac NJ, Jacobs WR Jr, Holzenburg A, Sacchettini JC, Alland D. Colangeli R, et al. Among authors: hazbon mh. Mol Microbiol. 2005 Mar;55(6):1829-40. doi: 10.1111/j.1365-2958.2005.04510.x. Mol Microbiol. 2005. PMID: 15752203 Free article.
Role of embB codon 306 mutations in Mycobacterium tuberculosis revisited: a novel association with broad drug resistance and IS6110 clustering rather than ethambutol resistance.
Hazbón MH, Bobadilla del Valle M, Guerrero MI, Varma-Basil M, Filliol I, Cavatore M, Colangeli R, Safi H, Billman-Jacobe H, Lavender C, Fyfe J, García-García L, Davidow A, Brimacombe M, León CI, Porras T, Bose M, Chaves F, Eisenach KD, Sifuentes-Osornio J, Ponce de León A, Cave MD, Alland D. Hazbón MH, et al. Antimicrob Agents Chemother. 2005 Sep;49(9):3794-802. doi: 10.1128/AAC.49.9.3794-3802.2005. Antimicrob Agents Chemother. 2005. PMID: 16127055 Free PMC article.
34 results