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In vitro antiviral activity of the novel, tyrosyl-based human immunodeficiency virus (HIV) type 1 protease inhibitor brecanavir (GW640385) in combination with other antiretrovirals and against a panel of protease inhibitor-resistant HIV.
Hazen R, Harvey R, Ferris R, Craig C, Yates P, Griffin P, Miller J, Kaldor I, Ray J, Samano V, Furfine E, Spaltenstein A, Hale M, Tung R, St Clair M, Hanlon M, Boone L. Hazen R, et al. Antimicrob Agents Chemother. 2007 Sep;51(9):3147-54. doi: 10.1128/AAC.00401-07. Epub 2007 Jul 9. Antimicrob Agents Chemother. 2007. PMID: 17620375 Free PMC article.
Optimization of pyrrolidinone based HIV protease inhibitors.
Sherrill RG, Andrews CW, Bock WJ, Davis-Ward RG, Furfine ES, Hazen RJ, Rutkowske RD, Spaltenstein A, Wright LL. Sherrill RG, et al. Bioorg Med Chem Lett. 2005 Jan 3;15(1):81-4. doi: 10.1016/j.bmcl.2004.10.029. Bioorg Med Chem Lett. 2005. PMID: 15582415
Antiviral activity of GW678248, a novel benzophenone nonnucleoside reverse transcriptase inhibitor.
Ferris RG, Hazen RJ, Roberts GB, St Clair MH, Chan JH, Romines KR, Freeman GA, Tidwell JH, Schaller LT, Cowan JR, Short SA, Weaver KL, Selleseth DW, Moniri KR, Boone LR. Ferris RG, et al. Among authors: hazen rj. Antimicrob Agents Chemother. 2005 Oct;49(10):4046-51. doi: 10.1128/AAC.49.10.4046-4051.2005. Antimicrob Agents Chemother. 2005. PMID: 16189079 Free PMC article.
Anti-human immunodeficiency virus type 1 activity of the nonnucleoside reverse transcriptase inhibitor GW678248 in combination with other antiretrovirals against clinical isolate viruses and in vitro selection for resistance.
Hazen RJ, Harvey RJ, St Clair MH, Ferris RG, Freeman GA, Tidwell JH, Schaller LT, Cowan JR, Short SA, Romines KR, Chan JH, Boone LR. Hazen RJ, et al. Antimicrob Agents Chemother. 2005 Nov;49(11):4465-73. doi: 10.1128/AAC.49.11.4465-4473.2005. Antimicrob Agents Chemother. 2005. PMID: 16251284 Free PMC article.
Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: the discovery of GW0385.
Miller JF, Andrews CW, Brieger M, Furfine ES, Hale MR, Hanlon MH, Hazen RJ, Kaldor I, McLean EW, Reynolds D, Sammond DM, Spaltenstein A, Tung R, Turner EM, Xu RX, Sherrill RG. Miller JF, et al. Among authors: hazen rj. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1788-94. doi: 10.1016/j.bmcl.2006.01.035. Epub 2006 Feb 3. Bioorg Med Chem Lett. 2006. PMID: 16458505
The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral.
Garvey EP, Johns BA, Gartland MJ, Foster SA, Miller WH, Ferris RG, Hazen RJ, Underwood MR, Boros EE, Thompson JB, Weatherhead JG, Koble CS, Allen SH, Schaller LT, Sherrill RG, Yoshinaga T, Kobayashi M, Wakasa-Morimoto C, Miki S, Nakahara K, Noshi T, Sato A, Fujiwara T. Garvey EP, et al. Among authors: hazen rj. Antimicrob Agents Chemother. 2008 Mar;52(3):901-8. doi: 10.1128/AAC.01218-07. Epub 2007 Dec 26. Antimicrob Agents Chemother. 2008. PMID: 18160521 Free PMC article.
164 results