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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
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2002 12
2003 12
2004 11
2005 21
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2007 34
2008 55
2009 56
2010 74
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2012 100
2013 103
2014 139
2015 160
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2,439 results

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Page 1
HDAC6 as privileged target in drug discovery: A perspective.
Pulya S, Amin SA, Adhikari N, Biswas S, Jha T, Ghosh B. Pulya S, et al. Pharmacol Res. 2021 Jan;163:105274. doi: 10.1016/j.phrs.2020.105274. Epub 2020 Nov 7. Pharmacol Res. 2021. PMID: 33171304 Review.
HDAC6, a class IIB HDAC isoenzyme, stands unique in its structural and physiological functions. ...This review details the study about the structural biology of HDAC6, the physiological and pathological role of HDAC6 in several disease states and the detailed …
HDAC6, a class IIB HDAC isoenzyme, stands unique in its structural and physiological functions. ...This review details the study abou …
The HDAC6-RNF168 axis regulates H2A/H2A.X ubiquitination to enable double-strand break repair.
Qiu L, Xu W, Lu X, Chen F, Chen Y, Tian Y, Zhu Q, Liu X, Wang Y, Pei XH, Xu X, Zhang J, Zhu WG. Qiu L, et al. Nucleic Acids Res. 2023 Sep 22;51(17):9166-9182. doi: 10.1093/nar/gkad631. Nucleic Acids Res. 2023. PMID: 37503842 Free PMC article.
Whether HDAC6 also mediates DNA double-strand break (DSB) repair is unclear. ...Upon sensing DSBs, RNF168 rapidly ubiquitinates HDAC6 at lysine 116, leading to HDAC6 proteasomal degradation and a restored interaction between RNF168 and H2A/H2A.X. ...
Whether HDAC6 also mediates DNA double-strand break (DSB) repair is unclear. ...Upon sensing DSBs, RNF168 rapidly ubiquitinates HD …
HDAC6 in Diseases of Cognition and of Neurons.
LoPresti P. LoPresti P. Cells. 2020 Dec 23;10(1):12. doi: 10.3390/cells10010012. Cells. 2020. PMID: 33374719 Free PMC article. Review.
These three HDAC6 activities could work independently or in synergy. Of particular interest, HDAC6 targets the synaptic protein Bruchpilot and neurotransmitter release. ...Thus, HDAC6 plays a leading role in neuronal health or dysfunction. Here, we review rec …
These three HDAC6 activities could work independently or in synergy. Of particular interest, HDAC6 targets the synaptic protei …
Curriculum vitae of HDAC6 in solid tumors.
Zheng YC, Kang HQ, Wang B, Zhu YZ, Mamun MAA, Zhao LF, Nie HQ, Liu Y, Zhao LJ, Zhang XN, Gao MM, Jiang DD, Liu HM, Gao Y. Zheng YC, et al. Int J Biol Macromol. 2023 Mar 1;230:123219. doi: 10.1016/j.ijbiomac.2023.123219. Epub 2023 Jan 13. Int J Biol Macromol. 2023. PMID: 36642357 Review.
Currently, the use of HDAC6 specific inhibitors, individually or in combination, is among the most promising therapies in solid tumors. This review's objective is to give a general overview of the structure, biological functions, and mechanism of HDAC6 in solid tumo …
Currently, the use of HDAC6 specific inhibitors, individually or in combination, is among the most promising therapies in solid tumor …
An HDAC6 inhibitor reverses chemotherapy-induced mechanical hypersensitivity via an IL-10 and macrophage dependent pathway.
Zhang J, Ma J, Trinh RT, Heijnen CJ, Kavelaars A. Zhang J, et al. Brain Behav Immun. 2022 Feb;100:287-296. doi: 10.1016/j.bbi.2021.12.005. Epub 2021 Dec 13. Brain Behav Immun. 2022. PMID: 34915156 Free PMC article.
We showed previously that deletion of Hdac6 from sensory neurons did not prevent cisplatin-induced mechanical hypersensitivity, while global deletion of Hdac6 was protective, indicating involvement of HDAC6 in other cell types. ...The HDAC6 inhibitor i …
We showed previously that deletion of Hdac6 from sensory neurons did not prevent cisplatin-induced mechanical hypersensitivity, while …
New insights into the non-enzymatic function of HDAC6.
Zhu Y, Feng M, Wang B, Zheng Y, Jiang D, Zhao L, Mamun MAA, Kang H, Nie H, Zhang X, Guo N, Qin S, Wang N, Liu H, Gao Y. Zhu Y, et al. Biomed Pharmacother. 2023 May;161:114438. doi: 10.1016/j.biopha.2023.114438. Epub 2023 Mar 9. Biomed Pharmacother. 2023. PMID: 37002569 Free article. Review.
However, HDAC6 is also capable of blocking virus invasion and replication in a non-enzymatic manner. ...Small molecule inhibitors targeting the ubiquitin binding pocket of HDAC6 have been investigated. In this review, we focus on mechanisms in non-enzymatic function …
However, HDAC6 is also capable of blocking virus invasion and replication in a non-enzymatic manner. ...Small molecule inhibitors tar …
Targeting HDAC6 to Overcome Autophagy-Promoted Anti-Cancer Drug Resistance.
Jo H, Shim K, Jeoung D. Jo H, et al. Int J Mol Sci. 2022 Aug 24;23(17):9592. doi: 10.3390/ijms23179592. Int J Mol Sci. 2022. PMID: 36076996 Free PMC article. Review.
The development of HDAC6-specific inhibitors has been relatively successful. Mechanisms of HDAC6-promoted anti-cancer drug resistance, cancer cell proliferation, and autophagy are discussed. ...A summary of clinical trials involving HDAC6-specific inhibitors …
The development of HDAC6-specific inhibitors has been relatively successful. Mechanisms of HDAC6-promoted anti-cancer drug res …
HDAC6 modulates myofibril stiffness and diastolic function of the heart.
Lin YH, Major JL, Liebner T, Hourani Z, Travers JG, Wennersten SA, Haefner KR, Cavasin MA, Wilson CE, Jeong MY, Han Y, Gotthardt M, Ferguson SK, Ambardekar AV, Lam MP, Choudhary C, Granzier HL, Woulfe KC, McKinsey TA. Lin YH, et al. J Clin Invest. 2022 May 16;132(10):e148333. doi: 10.1172/JCI148333. J Clin Invest. 2022. PMID: 35575093 Free PMC article.
Conversely, HDAC6 overexpression in cardiomyocytes led to decreased myofibril stiffness, as did ex vivo treatment of mouse, rat, and human myofibrils with recombinant HDAC6. ...HDAC6 colocalized with Z-disks, and proteomics analysis suggested that HDAC6 …
Conversely, HDAC6 overexpression in cardiomyocytes led to decreased myofibril stiffness, as did ex vivo treatment of mouse, rat, and …
HDAC6: A unique HDAC family member as a cancer target.
Kaur S, Rajoria P, Chopra M. Kaur S, et al. Cell Oncol (Dordr). 2022 Oct;45(5):779-829. doi: 10.1007/s13402-022-00704-6. Epub 2022 Aug 29. Cell Oncol (Dordr). 2022. PMID: 36036883 Review.
Recent findings have considerably expanded the research related to the substrate pool, biological functions and regulation of HDAC6. Studies in HDAC6 knockout mice highlighted the importance of HDAC6 as a cell survival player in stressful situations, making i …
Recent findings have considerably expanded the research related to the substrate pool, biological functions and regulation of HDAC6. …
HDAC6 inhibition: a significant potential regulator and therapeutic option to translate into clinical practice in renal transplantation.
Zhang QQ, Zhang WJ, Chang S. Zhang QQ, et al. Front Immunol. 2023 Jul 21;14:1168848. doi: 10.3389/fimmu.2023.1168848. eCollection 2023. Front Immunol. 2023. PMID: 37545520 Free PMC article. Review.
To date, a substantial amount of validated studies has identified HDAC6 as a pivotal modulator of innate and adaptive immunity, and HDAC6 inhibitors (HDAC6i) are being developed and investigated for use in arrays of immune-related diseases, making HDAC6i a promising …
To date, a substantial amount of validated studies has identified HDAC6 as a pivotal modulator of innate and adaptive immunity, and …
2,439 results