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Positive and negative modulation of group I metabotropic glutamate receptors.
Vanejevs M, Jatzke C, Renner S, Müller S, Hechenberger M, Bauer T, Klochkova A, Pyatkin I, Kazyulkin D, Aksenova E, Shulepin S, Timonina O, Haasis A, Gutcaits A, Parsons CG, Kauss V, Weil T. Vanejevs M, et al. Among authors: hechenberger m. J Med Chem. 2008 Feb 14;51(3):634-47. doi: 10.1021/jm0611298. Epub 2008 Jan 4. J Med Chem. 2008. PMID: 18173231
Discovery, synthesis, and structure-activity relationships of 2-aminoquinazoline derivatives as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators.
Kubas H, Meyer U, Krueger B, Hechenberger M, Vanejevs M, Zemribo R, Kauss V, Ambartsumova R, Pyatkin I, Polosukhin AI, Abel U. Kubas H, et al. Among authors: hechenberger m. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4493-500. doi: 10.1016/j.bmcl.2013.06.049. Epub 2013 Jun 25. Bioorg Med Chem Lett. 2013. PMID: 23856046
Pharmacological characterization of MRZ-8676, a novel negative allosteric modulator of subtype 5 metabotropic glutamate receptors (mGluR5): focus on L: -DOPA-induced dyskinesia.
Dekundy A, Gravius A, Hechenberger M, Pietraszek M, Nagel J, Tober C, van der Elst M, Mela F, Parsons CG, Danysz W. Dekundy A, et al. Among authors: hechenberger m. J Neural Transm (Vienna). 2011 Dec;118(12):1703-16. doi: 10.1007/s00702-010-0526-0. Epub 2010 Dec 16. J Neural Transm (Vienna). 2011. PMID: 21161716
Searching for drug scaffolds with 3D pharmacophores and neural network ensembles.
Renner S, Hechenberger M, Noeske T, Böcker A, Jatzke C, Schmuker M, Parsons CG, Weil T, Schneider G. Renner S, et al. Among authors: hechenberger m. Angew Chem Int Ed Engl. 2007;46(28):5336-9. doi: 10.1002/anie.200604125. Angew Chem Int Ed Engl. 2007. PMID: 17604383 No abstract available.
Potency, voltage-dependency, agonist concentration-dependency, blocking kinetics and partial untrapping of the uncompetitive N-methyl-D-aspartate (NMDA) channel blocker memantine at human NMDA (GluN1/GluN2A) receptors.
Gilling KE, Jatzke C, Hechenberger M, Parsons CG. Gilling KE, et al. Among authors: hechenberger m. Neuropharmacology. 2009 Apr;56(5):866-75. doi: 10.1016/j.neuropharm.2009.01.012. Epub 2009 Jan 21. Neuropharmacology. 2009. PMID: 19371579
16 results