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Rapid chemical antagonism of neuromuscular blockade by L-cysteine adduction to and inactivation of the olefinic (double-bonded) isoquinolinium diester compounds gantacurium (AV430A), CW 002, and CW 011.
Savarese JJ, McGilvra JD, Sunaga H, Belmont MR, Van Ornum SG, Savard PM, Heerdt PM. Savarese JJ, et al. Among authors: heerdt pm. Anesthesiology. 2010 Jul;113(1):58-73. doi: 10.1097/ALN.0b013e3181dc1b5b. Anesthesiology. 2010. PMID: 20526187 Free article.
Novel neuromuscular blocking drugs and antagonists.
Heerdt PM, Sunaga H, Savarese JJ. Heerdt PM, et al. Curr Opin Anaesthesiol. 2015 Aug;28(4):403-10. doi: 10.1097/ACO.0000000000000209. Curr Opin Anaesthesiol. 2015. PMID: 26087274 Review.
Preclinical Pharmacology of CW002: A Nondepolarizing Neuromuscular Blocking Drug of Intermediate Duration, Degraded and Antagonized by l-cysteine-Additional Studies of Safety and Efficacy in the Anesthetized Rhesus Monkey and Cat.
Sunaga H, Savarese JJ, McGilvra JD, Heerdt PM, Belmont MR, Van Ornum SG, Murrell MT, Malhotra JK, Savard PM, Jeannotte E, Petty BJ, Allen E, Carnathan GW. Sunaga H, et al. Among authors: heerdt pm. Anesthesiology. 2016 Oct;125(4):732-743. doi: 10.1097/ALN.0000000000001254. Anesthesiology. 2016. PMID: 27466033 Free article.
111 results