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The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells.
Courtney M, Gjernes E, Druelle N, Ravaud C, Vieira A, Ben-Othman N, Pfeifer A, Avolio F, Leuckx G, Lacas-Gervais S, Burel-Vandenbos F, Ambrosetti D, Hecksher-Sorensen J, Ravassard P, Heimberg H, Mansouri A, Collombat P. Courtney M, et al. Among authors: heimberg h. PLoS Genet. 2013 Oct;9(10):e1003934. doi: 10.1371/journal.pgen.1003934. Epub 2013 Oct 31. PLoS Genet. 2013. PMID: 24204325 Free PMC article.
Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming.
Swales N, Martens GA, Bonné S, Heremans Y, Borup R, Van de Casteele M, Ling Z, Pipeleers D, Ravassard P, Nielsen F, Ferrer J, Heimberg H. Swales N, et al. Among authors: heimberg h. PLoS One. 2012;7(5):e37055. doi: 10.1371/journal.pone.0037055. Epub 2012 May 14. PLoS One. 2012. PMID: 22606327 Free PMC article.
Gene delivery to pancreatic exocrine cells in vivo and in vitro.
Houbracken I, Baeyens L, Ravassard P, Heimberg H, Bouwens L. Houbracken I, et al. Among authors: heimberg h. BMC Biotechnol. 2012 Oct 22;12:74. doi: 10.1186/1472-6750-12-74. BMC Biotechnol. 2012. PMID: 23088534 Free PMC article.
Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes.
Al-Hasani K, Pfeifer A, Courtney M, Ben-Othman N, Gjernes E, Vieira A, Druelle N, Avolio F, Ravassard P, Leuckx G, Lacas-Gervais S, Ambrosetti D, Benizri E, Hecksher-Sorensen J, Gounon P, Ferrer J, Gradwohl G, Heimberg H, Mansouri A, Collombat P. Al-Hasani K, et al. Among authors: heimberg h. Dev Cell. 2013 Jul 15;26(1):86-100. doi: 10.1016/j.devcel.2013.05.018. Epub 2013 Jun 27. Dev Cell. 2013. PMID: 23810513 Free article.
Suppression of epithelial-to-mesenchymal transitioning enhances ex vivo reprogramming of human exocrine pancreatic tissue toward functional insulin-producing β-like cells.
Lima MJ, Muir KR, Docherty HM, Drummond R, McGowan NW, Forbes S, Heremans Y, Houbracken I, Ross JA, Forbes SJ, Ravassard P, Heimberg H, Casey J, Docherty K. Lima MJ, et al. Among authors: heimberg h. Diabetes. 2013 Aug;62(8):2821-33. doi: 10.2337/db12-1256. Epub 2013 Apr 22. Diabetes. 2013. PMID: 23610058 Free PMC article.
122 results