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1956 1
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1973 2
1974 1
1975 17
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1980 27
1981 38
1982 36
1983 50
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1986 76
1987 83
1988 80
1989 90
1990 84
1991 121
1992 107
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1995 112
1996 110
1997 107
1998 102
1999 112
2000 117
2001 112
2002 124
2003 115
2004 130
2005 153
2006 167
2007 178
2008 175
2009 201
2010 172
2011 213
2012 202
2013 251
2014 245
2015 274
2016 282
2017 264
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2019 332
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6,522 results

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Page 1
Biomarkers of Parkinson's disease: present and future.
Miller DB, O'Callaghan JP. Miller DB, et al. Metabolism. 2015 Mar;64(3 Suppl 1):S40-6. doi: 10.1016/j.metabol.2014.10.030. Epub 2014 Oct 31. Metabolism. 2015. PMID: 25510818 Free PMC article. Review.
PD neuropathology is characterized by a selective loss of dopaminergic neurons in the substantia nigra pars compacta; however, more widespread involvement of other CNS structures and peripheral tissues now is widely documented. ...
PD neuropathology is characterized by a selective loss of dopaminergic neurons in the substantia nigra pars compacta; however, more w …
Upregulated hexokinase 2 expression induces the apoptosis of dopaminergic neurons by promoting lactate production in Parkinson's disease.
Li J, Chen L, Qin Q, Wang D, Zhao J, Gao H, Yuan X, Zhang J, Zou Y, Mao Z, Xiong Y, Min Z, Yan M, Wang CY, Xue Z. Li J, et al. Neurobiol Dis. 2022 Feb;163:105605. doi: 10.1016/j.nbd.2021.105605. Epub 2021 Dec 29. Neurobiol Dis. 2022. PMID: 34973450 Free article.
In this study, we examined the expression of hexokinase 2 (HK2) and lactate dehydrogenase (LDH), the key enzymes in glycolysis, and lactate levels in the substantia nigra pars compacta (SNpc) of a MPTP-induced mouse model of PD and in MPP(+)-treated SH-SY5Y cells. ...
In this study, we examined the expression of hexokinase 2 (HK2) and lactate dehydrogenase (LDH), the key enzymes in glycolysis, and lactate …
Uncovering Novel Therapeutic Targets for Parkinson's Disease.
Soni R, Delvadia P, Joharapurkar A, Shah J. Soni R, et al. ACS Chem Neurosci. 2023 Jun 7;14(11):1935-1949. doi: 10.1021/acschemneuro.3c00084. Epub 2023 May 25. ACS Chem Neurosci. 2023. PMID: 37227448 Review.
PD pathogenesis is mainly characterized by deposits of inclusion bodies on dopaminergic (DA) neurons in substantia nigra pars compacta region (SNpc) of the brain. The major component of these inclusion bodies, are alpha-synuclein aggregates. alpha-Synuclein undergoes misfo …
PD pathogenesis is mainly characterized by deposits of inclusion bodies on dopaminergic (DA) neurons in substantia nigra pars compacta …
Parkinson’s Disease: Basic knowledge.
Rose O. Rose O. Med Monatsschr Pharm. 2016 Jul;39(7):277-81. Med Monatsschr Pharm. 2016. PMID: 29953178 Review. English, German.
Neurodegeneration with formation of Lewy-bodies and increased oxidative stress in the pars compacta of the substantia nigra are closely linked to IPD. Lewy-bodies show misfolded alpha-Synuclein. ...
Neurodegeneration with formation of Lewy-bodies and increased oxidative stress in the pars compacta of the substantia nigra are close …
Parkinson's Disease: Exploring Different Animal Model Systems.
Khan E, Hasan I, Haque ME. Khan E, et al. Int J Mol Sci. 2023 May 22;24(10):9088. doi: 10.3390/ijms24109088. Int J Mol Sci. 2023. PMID: 37240432 Free PMC article. Review.
The pathological hallmarks of Parkinson's disease are associated with the accumulation of misfolded protein called alpha-synuclein as Lewy body, and degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc) area affecting the patient's motor activity …
The pathological hallmarks of Parkinson's disease are associated with the accumulation of misfolded protein called alpha-synuclein as Lewy b …
Specific vulnerability of substantia nigra compacta neurons.
Smidt MP. Smidt MP. J Neural Transm Suppl. 2009;(73):39-47. doi: 10.1007/978-3-211-92660-4_3. J Neural Transm Suppl. 2009. PMID: 20411766 Review.
The specific loss of substantia nigra compacta (SNc) neurons in Parkinson's disease (PD) has been the main driving force in initiating research efforts to unravel the apparent SNc-specific vulnerability. ...
The specific loss of substantia nigra compacta (SNc) neurons in Parkinson's disease (PD) has been the main driving force in initiatin …
Assessment of Dopaminergic Neurodegeneration in Mice.
Geertsma HM, Ricke KM, Rousseaux MWC. Geertsma HM, et al. Methods Mol Biol. 2022;2515:151-169. doi: 10.1007/978-1-0716-2409-8_10. Methods Mol Biol. 2022. PMID: 35776351
Here, we provide a detailed step-by-step guide for the quantification of dopaminergic neurons in the substantia nigra pars compacta, a brain area prone to neuron loss in PD. In addition, we outline the protocol for the analysis of the dopaminergic terminals in the striatum …
Here, we provide a detailed step-by-step guide for the quantification of dopaminergic neurons in the substantia nigra pars compacta, …
Incarvillea compacta Maxim ameliorates inflammatory response via inhibiting PI3K/AKT pathway and NLRP3 activation.
Zhang J, Feng Y, Han S, Guan X, He Z, Song C, Lv L, Luo Q. Zhang J, et al. Front Pharmacol. 2022 Oct 28;13:1058012. doi: 10.3389/fphar.2022.1058012. eCollection 2022. Front Pharmacol. 2022. PMID: 36386225 Free PMC article.
Incarvillea compacta Maxim is a traditional Tibetan medicine used to treat inflammation-related diseases, such as pneumonia, fever, jaundice, and otitis media. ...Therefore, the results of this study obtained scientific evidence supporting the use of I. compacta....
Incarvillea compacta Maxim is a traditional Tibetan medicine used to treat inflammation-related diseases, such as pneumonia, fever, j …
Intramyocardial microarteriopathy.
Rahlf G. Rahlf G. Virchows Arch A Pathol Anat Histol. 1980;388(3):289-311. doi: 10.1007/BF00430860. Virchows Arch A Pathol Anat Histol. 1980. PMID: 7434560
Severe vascular changes are seen in the 7th to 9th decade in about 5-10% (compacta type) and in 30-35% (papillary muscle type) respectively. 5. ...It appears that pathological vascular lesions occur less frequently in compacta type vessels in cases of high-grade ste …
Severe vascular changes are seen in the 7th to 9th decade in about 5-10% (compacta type) and in 30-35% (papillary muscle type) respec …
6,522 results