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Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo.
Reuberson J, Horsley H, Franklin RJ, Ford D, Neuss J, Brookings D, Huang Q, Vanderhoydonck B, Gao LJ, Jang MY, Herdewijn P, Ghawalkar A, Fallah-Arani F, Khan AR, Henshall J, Jairaj M, Malcolm S, Ward E, Shuttleworth L, Lin Y, Li S, Louat T, Waer M, Herman J, Payne A, Ceska T, Doyle C, Pitt W, Calmiano M, Augustin M, Steinbacher S, Lammens A, Allen R. Reuberson J, et al. Among authors: herman j. J Med Chem. 2018 Aug 9;61(15):6705-6723. doi: 10.1021/acs.jmedchem.8b00521. Epub 2018 Jul 19. J Med Chem. 2018. PMID: 29952567
Synthesis and in vitro evaluation of 2-amino-4-N-piperazinyl-6-(3,4-dimethoxyphenyl)-pteridines as dual immunosuppressive and anti-inflammatory agents.
De Jonghe S, Marchand A, Gao LJ, Calleja A, Cuveliers E, Sienaert I, Herman J, Clydesdale G, Sefrioui H, Lin Y, Pfleiderer W, Waer M, Herdewijn P. De Jonghe S, et al. Among authors: herman j. Bioorg Med Chem Lett. 2011 Jan 1;21(1):145-9. doi: 10.1016/j.bmcl.2010.11.053. Epub 2010 Nov 16. Bioorg Med Chem Lett. 2011. PMID: 21131199 Free article.
Synthesis and evaluation of 5-substituted 2'-deoxyuridine monophosphate analogues as inhibitors of flavin-dependent thymidylate synthase in Mycobacterium tuberculosis.
Kögler M, Vanderhoydonck B, De Jonghe S, Rozenski J, Van Belle K, Herman J, Louat T, Parchina A, Sibley C, Lescrinier E, Herdewijn P. Kögler M, et al. Among authors: herman j. J Med Chem. 2011 Jul 14;54(13):4847-62. doi: 10.1021/jm2004688. Epub 2011 Jun 9. J Med Chem. 2011. PMID: 21657202 Free article.
Structure-based drug repositioning explains ibrutinib as VEGFR2 inhibitor.
Adasme MF, Parisi D, Van Belle K, Salentin S, Haupt VJ, Jennings GS, Heinrich JC, Herman J, Sprangers B, Louat T, Moreau Y, Schroeder M. Adasme MF, et al. Among authors: herman j. PLoS One. 2020 May 27;15(5):e0233089. doi: 10.1371/journal.pone.0233089. eCollection 2020. PLoS One. 2020. PMID: 32459810 Free PMC article.
2,319 results