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CLL cells cumulate genetic aberrations prior to the first therapy even in outwardly inactive disease phase.
Hernández-Sánchez M, Kotaskova J, Rodríguez AE, Radova L, Tamborero D, Abáigar M, Plevova K, Benito R, Tom N, Quijada-Álamo M, Bikos V, Martín AÁ, Pal K, García de Coca A, Doubek M, López-Bigas N, Hernández-Rivas JM, Pospisilova S. Hernández-Sánchez M, et al. Leukemia. 2019 Feb;33(2):518-558. doi: 10.1038/s41375-018-0255-1. Epub 2018 Sep 12. Leukemia. 2019. PMID: 30209402 Free PMC article. No abstract available.
Molecular characterization of chronic lymphocytic leukemia patients with a high number of losses in 13q14.
Rodríguez AE, Hernández JÁ, Benito R, Gutiérrez NC, García JL, Hernández-Sánchez M, Risueño A, Sarasquete ME, Fermiñán E, Fisac R, de Coca AG, Martín-Núñez G, de Las Heras N, Recio I, Gutiérrez O, De Las Rivas J, González M, Hernández-Rivas JM. Rodríguez AE, et al. PLoS One. 2012;7(11):e48485. doi: 10.1371/journal.pone.0048485. Epub 2012 Nov 13. PLoS One. 2012. PMID: 23152777 Free PMC article.
Mutation status and immunoglobulin gene rearrangements in patients from northwest and central region of Spain with chronic lymphocytic leukemia.
González-Gascón Y Marín I, Hernández JA, Martín A, Alcoceba M, Sarasquete ME, Rodríguez-Vicente A, Heras C, de Las Heras N, Fisac R, García de Coca A, de la Fuente I, Hernández-Sánchez M, Recio I, Galende J, Martín-Núñez G, Alonso JM, Hernández-Rivas JM, González M. González-Gascón Y Marín I, et al. Biomed Res Int. 2014;2014:257517. doi: 10.1155/2014/257517. Epub 2014 Mar 30. Biomed Res Int. 2014. PMID: 24790994 Free PMC article.
A high proportion of cells carrying trisomy 12 is associated with a worse outcome in patients with chronic lymphocytic leukemia.
González-Gascón Y Marín I, Hernández-Sánchez M, Rodríguez-Vicente AE, Sanzo C, Aventín A, Puiggros A, Collado R, Heras C, Muñoz C, Delgado J, Ortega M, González MT, Marugán I, de la Fuente I, Recio I, Bosch F, Espinet B, González M, Hernández-Rivas JM, Hernández JÁ; Grupo Español de Leucemia Linfática Crónica (GELLC); Grupo Cooperativo Español de Citogenética Hematológica (GCECGH). González-Gascón Y Marín I, et al. Hematol Oncol. 2016 Jun;34(2):84-92. doi: 10.1002/hon.2196. Epub 2015 Feb 17. Hematol Oncol. 2016. PMID: 25689772
MicroRNA-223 is a novel negative regulator of HSP90B1 in CLL.
Rodríguez-Vicente AE, Quwaider D, Benito R, Misiewicz-Krzeminska I, Hernández-Sánchez M, de Coca AG, Fisac R, Alonso JM, Zato C, de Paz JF, García JL, Sarasquete ME, Hernández JÁ, Corchado JM, González M, Gutiérrez NC, Hernández-Rivas JM. Rodríguez-Vicente AE, et al. BMC Cancer. 2015 Apr 8;15:238. doi: 10.1186/s12885-015-1212-2. BMC Cancer. 2015. PMID: 25880332 Free PMC article.
The presence of genomic imbalances is associated with poor outcome in patients with burkitt lymphoma treated with dose-intensive chemotherapy including rituximab.
Forero-Castro M, Robledo C, Lumbreras E, Benito R, Hernández-Sánchez JM, Hernández-Sánchez M, García JL, Corchete-Sánchez LA, Tormo M, Barba P, Menárguez J, Ribera J, Grande C, Escoda L, Olivier C, Carrillo E, García de Coca A, Ribera JM, Hernández-Rivas JM. Forero-Castro M, et al. Br J Haematol. 2016 Feb;172(3):428-38. doi: 10.1111/bjh.13849. Epub 2015 Nov 16. Br J Haematol. 2016. PMID: 26567765 Free article.
A Low Frequency of Losses in 11q Chromosome Is Associated with Better Outcome and Lower Rate of Genomic Mutations in Patients with Chronic Lymphocytic Leukemia.
Hernández JÁ, Hernández-Sánchez M, Rodríguez-Vicente AE, Grossmann V, Collado R, Heras C, Puiggros A, Martín AÁ, Puig N, Benito R, Robledo C, Delgado J, González T, Queizán JA, Galende J, de la Fuente I, Martín-Núñez G, Alonso JM, Abrisqueta P, Luño E, Marugán I, González-Gascón I, Bosch F, Kohlmann A, González M, Espinet B, Hernández-Rivas JM; Grupo Cooperativo Español de Citogenética Hematológica (GCECGH) and Grupo Español de Leucemia Linfática Crónica (GELLC). Hernández JÁ, et al. PLoS One. 2015 Dec 2;10(11):e0143073. doi: 10.1371/journal.pone.0143073. eCollection 2015. PLoS One. 2015. PMID: 26630574 Free PMC article.
MiRNA expression profile of chronic lymphocytic leukemia patients with 13q deletion.
Hernández-Sánchez M, Rodríguez-Vicente AE, Hernández JÁ, Lumbreras E, Sarasquete ME, Martín AÁ, Benito R, Vicente-Gutiérrez C, Robledo C, Heras Nde L, Rodríguez JN, Alcoceba M, Coca AG, Aguilar C, González M, Hernández-Rivas JM. Hernández-Sánchez M, et al. Leuk Res. 2016 Jul;46:30-6. doi: 10.1016/j.leukres.2016.04.008. Epub 2016 Apr 12. Leuk Res. 2016. PMID: 27111859
Hyperdiploidy as a rare event that accompanies poor prognosis markers in CLL.
González-Gascón Y Marín I, Martín AÁ, Hernández-Sanchez M, Robledo C, Hermosín ML, de Las Heras N, Lacalle L, Galende J, de Arriba F, Rodríguez-Vicente AE, Hernández JÁ, Hernández-Rivas JM. González-Gascón Y Marín I, et al. Eur J Haematol. 2017 Feb;98(2):142-148. doi: 10.1111/ejh.12812. Epub 2016 Oct 12. Eur J Haematol. 2017. PMID: 27717146
80 results