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Increased somatic mutation burdens in normal human cells due to defective DNA polymerases.
Robinson PS, Coorens THH, Palles C, Mitchell E, Abascal F, Olafsson S, Lee BCH, Lawson ARJ, Lee-Six H, Moore L, Sanders MA, Hewinson J, Martin L, Pinna CMA, Galavotti S, Rahbari R, Campbell PJ, Martincorena I, Tomlinson I, Stratton MR. Robinson PS, et al. Among authors: hewinson j. Nat Genet. 2021 Oct;53(10):1434-1442. doi: 10.1038/s41588-021-00930-y. Epub 2021 Sep 30. Nat Genet. 2021. PMID: 34594041 Free PMC article.
Extensive phylogenies of human development inferred from somatic mutations.
Coorens THH, Moore L, Robinson PS, Sanghvi R, Christopher J, Hewinson J, Przybilla MJ, Lawson ARJ, Spencer Chapman M, Cagan A, Oliver TRW, Neville MDC, Hooks Y, Noorani A, Mitchell TJ, Fitzgerald RC, Campbell PJ, Martincorena I, Rahbari R, Stratton MR. Coorens THH, et al. Among authors: hewinson j. Nature. 2021 Sep;597(7876):387-392. doi: 10.1038/s41586-021-03790-y. Epub 2021 Aug 25. Nature. 2021. PMID: 34433963
Mutational landscape of normal epithelial cells in Lynch Syndrome patients.
Lee BCH, Robinson PS, Coorens THH, Yan HHN, Olafsson S, Lee-Six H, Sanders MA, Siu HC, Hewinson J, Yue SSK, Tsui WY, Chan ASY, Chan AKW, Ho SL, Campbell PJ, Martincorena I, Buczacki SJA, Yuen ST, Leung SY, Stratton MR. Lee BCH, et al. Among authors: hewinson j. Nat Commun. 2022 May 17;13(1):2710. doi: 10.1038/s41467-022-29920-2. Nat Commun. 2022. PMID: 35581206 Free PMC article.
The mutational signature profile of known and suspected human carcinogens in mice.
Riva L, Pandiri AR, Li YR, Droop A, Hewinson J, Quail MA, Iyer V, Shepherd R, Herbert RA, Campbell PJ, Sills RC, Alexandrov LB, Balmain A, Adams DJ. Riva L, et al. Among authors: hewinson j. Nat Genet. 2020 Nov;52(11):1189-1197. doi: 10.1038/s41588-020-0692-4. Epub 2020 Sep 28. Nat Genet. 2020. PMID: 32989322 Free PMC article.
Life histories of myeloproliferative neoplasms inferred from phylogenies.
Williams N, Lee J, Mitchell E, Moore L, Baxter EJ, Hewinson J, Dawson KJ, Menzies A, Godfrey AL, Green AR, Campbell PJ, Nangalia J. Williams N, et al. Among authors: hewinson j. Nature. 2022 Feb;602(7895):162-168. doi: 10.1038/s41586-021-04312-6. Epub 2022 Jan 20. Nature. 2022. PMID: 35058638
ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma.
Rashid M, van der Horst M, Mentzel T, Butera F, Ferreira I, Pance A, Rütten A, Luzar B, Marusic Z, de Saint Aubain N, Ko JS, Billings SD, Chen S, Abi Daoud M, Hewinson J, Louzada S, Harms PW, Cerretelli G, Robles-Espinoza CD, Patel RM, van der Weyden L, Bakal C, Hornick JL, Arends MJ, Brenn T, Adams DJ. Rashid M, et al. Among authors: hewinson j. Nat Commun. 2019 May 17;10(1):2213. doi: 10.1038/s41467-019-09979-0. Nat Commun. 2019. PMID: 31101826 Free PMC article.
A population-based analysis of germline BAP1 mutations in melanoma.
O'Shea SJ, Robles-Espinoza CD, McLellan L, Harrigan J, Jacq X, Hewinson J, Iyer V, Merchant W, Elliott F, Harland M, Bishop DT, Newton-Bishop JA, Adams DJ. O'Shea SJ, et al. Among authors: hewinson j. Hum Mol Genet. 2017 Feb 15;26(4):717-728. doi: 10.1093/hmg/ddw403. Hum Mol Genet. 2017. PMID: 28062663 Free PMC article.
Combinatorial CRISPR screen identifies fitness effects of gene paralogues.
Thompson NA, Ranzani M, van der Weyden L, Iyer V, Offord V, Droop A, Behan F, Gonçalves E, Speak A, Iorio F, Hewinson J, Harle V, Robertson H, Anderson E, Fu B, Yang F, Zagnoli-Vieira G, Chapman P, Del Castillo Velasco-Herrera M, Garnett MJ, Jackson SP, Adams DJ. Thompson NA, et al. Among authors: hewinson j. Nat Commun. 2021 Feb 26;12(1):1302. doi: 10.1038/s41467-021-21478-9. Nat Commun. 2021. PMID: 33637726 Free PMC article.
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