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1.45 A resolution crystal structure of recombinant PNP in complex with a pM multisubstrate analogue inhibitor bearing one feature of the postulated transition state.
Chojnowski G, Breer K, Narczyk M, Wielgus-Kutrowska B, Czapinska H, Hashimoto M, Hikishima S, Yokomatsu T, Bochtler M, Girstun A, Staroń K, Bzowska A. Chojnowski G, et al. Among authors: hikishima s. Biochem Biophys Res Commun. 2010 Jan 1;391(1):703-8. doi: 10.1016/j.bbrc.2009.11.124. Epub 2009 Nov 26. Biochem Biophys Res Commun. 2010. PMID: 19944078
9-Deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid are slow-binding picomolar inhibitors of trimeric purine nucleoside phosphorylase.
Breer K, Glavas-Obrovac L, Suver M, Hikishima S, Hashimoto M, Yokomatsu T, Wielgus-Kutrowska B, Magnowska L, Bzowska A. Breer K, et al. Among authors: hikishima s. FEBS J. 2010 Apr;277(7):1747-60. doi: 10.1111/j.1742-4658.2010.07598.x. Epub 2010 Feb 24. FEBS J. 2010. PMID: 20193043 Free article.
Inhibitory properties of nucleotides with difluoromethylenephosphonic acid as a phosphate mimic versus calf spleen purine nucleoside phosphorylase and effect of these analogues on the viability of human blood lymphocytes.
Glavas-Obrovac L, Suver M, Hikishima S, Yokomatsu T, Bzowska A. Glavas-Obrovac L, et al. Among authors: hikishima s. Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):989-93. doi: 10.1080/15257770701508513. Nucleosides Nucleotides Nucleic Acids. 2007. PMID: 18058523
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