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Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA.
Suno R, Kimura KT, Nakane T, Yamashita K, Wang J, Fujiwara T, Yamanaka Y, Im D, Horita S, Tsujimoto H, Tawaramoto MS, Hirokawa T, Nango E, Tono K, Kameshima T, Hatsui T, Joti Y, Yabashi M, Shimamoto K, Yamamoto M, Rosenbaum DM, Iwata S, Shimamura T, Kobayashi T. Suno R, et al. Among authors: hirokawa t. Structure. 2018 Jan 2;26(1):7-19.e5. doi: 10.1016/j.str.2017.11.005. Epub 2017 Dec 7. Structure. 2018. PMID: 29225076 Free article.
Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface.
Toyoda Y, Morimoto K, Suno R, Horita S, Yamashita K, Hirata K, Sekiguchi Y, Yasuda S, Shiroishi M, Shimizu T, Urushibata Y, Kajiwara Y, Inazumi T, Hotta Y, Asada H, Nakane T, Shiimura Y, Nakagita T, Tsuge K, Yoshida S, Kuribara T, Hosoya T, Sugimoto Y, Nomura N, Sato M, Hirokawa T, Kinoshita M, Murata T, Takayama K, Yamamoto M, Narumiya S, Iwata S, Kobayashi T. Toyoda Y, et al. Among authors: hirokawa t. Nat Chem Biol. 2019 Jan;15(1):18-26. doi: 10.1038/s41589-018-0131-3. Epub 2018 Dec 3. Nat Chem Biol. 2019. PMID: 30510193
Molecular mechanisms for sweet-suppressing effect of gymnemic acids.
Sanematsu K, Kusakabe Y, Shigemura N, Hirokawa T, Nakamura S, Imoto T, Ninomiya Y. Sanematsu K, et al. Among authors: hirokawa t. J Biol Chem. 2014 Sep 12;289(37):25711-20. doi: 10.1074/jbc.M114.560409. Epub 2014 Jul 23. J Biol Chem. 2014. PMID: 25056955 Free PMC article.
Unnatural Tripeptides as Potent Positive Allosteric Modulators of T1R2/T1R3.
Yamada K, Nakazawa M, Matsumoto K, Tagami U, Hirokawa T, Homma K, Mori S, Matsumoto R, Saikawa W, Kitajima S. Yamada K, et al. Among authors: hirokawa t. ACS Med Chem Lett. 2019 Mar 25;10(5):800-805. doi: 10.1021/acsmedchemlett.9b00051. eCollection 2019 May 9. ACS Med Chem Lett. 2019. PMID: 31098002 Free PMC article.
299 results