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Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate.
J Med Chem. 2006 Aug 10;49(16):4809-12. doi: 10.1021/jm060554y.
J Med Chem. 2006.
PMID: 16884291
Design and synthesis of non-hydroxamate histone deacetylase inhibitors: identification of a selective histone acetylating agent.
Suzuki T, Matsuura A, Kouketsu A, Hisakawa S, Nakagawa H, Miyata N.
Suzuki T, et al. Among authors: hisakawa s.
Bioorg Med Chem. 2005 Jul 1;13(13):4332-42. doi: 10.1016/j.bmc.2005.04.002.
Bioorg Med Chem. 2005.
PMID: 15927839
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Identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor.
Suzuki T, Hisakawa S, Itoh Y, Maruyama S, Kurotaki M, Nakagawa H, Miyata N.
Suzuki T, et al. Among authors: hisakawa s.
Bioorg Med Chem Lett. 2007 Mar 15;17(6):1558-61. doi: 10.1016/j.bmcl.2006.12.117. Epub 2007 Jan 13.
Bioorg Med Chem Lett. 2007.
PMID: 17257837
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Design, synthesis, and biological activity of folate receptor-targeted prodrugs of thiolate histone deacetylase inhibitors.
Suzuki T, Hisakawa S, Itoh Y, Suzuki N, Takahashi K, Kawahata M, Yamaguchi K, Nakagawa H, Miyata N.
Suzuki T, et al. Among authors: hisakawa s.
Bioorg Med Chem Lett. 2007 Aug 1;17(15):4208-12. doi: 10.1016/j.bmcl.2007.05.040. Epub 2007 May 17.
Bioorg Med Chem Lett. 2007.
PMID: 17532630
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Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship.
Aoki T, Yoshizawa H, Yamawaki K, Yokoo K, Sato J, Hisakawa S, Hasegawa Y, Kusano H, Sano M, Sugimoto H, Nishitani Y, Sato T, Tsuji M, Nakamura R, Nishikawa T, Yamano Y.
Aoki T, et al. Among authors: hisakawa s.
Eur J Med Chem. 2018 Jul 15;155:847-868. doi: 10.1016/j.ejmech.2018.06.014. Epub 2018 Jun 8.
Eur J Med Chem. 2018.
PMID: 29960205
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Synthesis of a 6-CF3-Substituted 2-Amino-dihydro-1,3-thiazine β-Secretase Inhibitor by N, N-Diethylaminosulfur Trifluoride-Mediated Chemoselective Cyclization.
Oguma T, Anan K, Suzuki S, Hisakawa S, Takada A, Ogawa M, Kusakabe KI.
Oguma T, et al. Among authors: hisakawa s.
J Org Chem. 2019 Apr 19;84(8):4893-4897. doi: 10.1021/acs.joc.8b02179. Epub 2018 Oct 29.
J Org Chem. 2019.
PMID: 30371078
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