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330 results

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HMGA1B/2 transcriptionally activated-POU1F1 facilitates gastric carcinoma metastasis via CXCL12/CXCR4 axis-mediated macrophage polarization.
Tang C, Lei X, Xiong L, Hu Z, Tang B. Tang C, et al. Cell Death Dis. 2021 Apr 29;12(5):422. doi: 10.1038/s41419-021-03703-x. Cell Death Dis. 2021. PMID: 33927188 Free PMC article.
GST pull-down and Co-immunoprecipitation (Co-IP) were used to study the interaction between HMGA1B/2 and POU1F1. Chromatin immunoprecipitation (ChIP) and dual luciferase reporter assays were performed to investigate the transcriptional regulation of POU1F1. ...POU1F1 also …
GST pull-down and Co-immunoprecipitation (Co-IP) were used to study the interaction between HMGA1B/2 and POU1F1. Chromatin immunoprec …
Setting up and exploitation of a nano/technological platform for the evaluation of HMGA1b protein in peripheral blood of cancer patients.
Capo A, Sepe R, Pellino G, Milone M, Malapelle U, Pellecchia S, Pepe F, Cacciola NA, Manigrasso M, Bruzzaniti S, Sciaudone G, De Palma GD, Galgani M, Selvaggi F, Troncone G, Fusco A, D'Auria S, Pallante P. Capo A, et al. Nanomedicine. 2019 Jan;15(1):231-242. doi: 10.1016/j.nano.2018.09.011. Epub 2018 Oct 9. Nanomedicine. 2019. PMID: 30308301
After having analyzed blood samples from colorectal cancer patients and healthy people for the presence of HMGA1b, we observed a 2-fold increase of the HMGA1b levels in the blood of cancer patients with respect to the healthy control people. We conclude that the set …
After having analyzed blood samples from colorectal cancer patients and healthy people for the presence of HMGA1b, we observed a 2-fo …
Expression of a truncated Hmga1b gene induces gigantism, lipomatosis and B-cell lymphomas in mice.
Fedele M, Visone R, De Martino I, Palmieri D, Valentino T, Esposito F, Klein-Szanto A, Arra C, Ciarmiello A, Croce CM, Fusco A. Fedele M, et al. Eur J Cancer. 2011 Feb;47(3):470-8. doi: 10.1016/j.ejca.2010.09.045. Epub 2010 Oct 31. Eur J Cancer. 2011. PMID: 21044834 Retracted.
Therefore, to define better the role of the HMGA1 alterations in the generation of human lipomas, we generated mice carrying an Hmga1b truncated (Hmga1b/T) gene. These mice develop a giant phenotype together with a drastic expansion of the retroperitoneal and subcut …
Therefore, to define better the role of the HMGA1 alterations in the generation of human lipomas, we generated mice carrying an Hmga1b …
CBX7 and HMGA1b proteins act in opposite way on the regulation of the SPP1 gene expression.
Sepe R, Formisano U, Federico A, Forzati F, Bastos AU, D'Angelo D, Cacciola NA, Fusco A, Pallante P. Sepe R, et al. Oncotarget. 2015 Feb 20;6(5):2680-92. doi: 10.18632/oncotarget.2777. Oncotarget. 2015. PMID: 25595895 Free PMC article.
We show that the SPP1 transcriptional regulation mechanism involves the CBX7-interacting protein HMGA1b, that acts as a positive regulator of the SPP1 gene. In fact, we demonstrate that, in contrast with the transcriptional activity of CBX7, HMGA1b is able to increa …
We show that the SPP1 transcriptional regulation mechanism involves the CBX7-interacting protein HMGA1b, that acts as a positive regu …
HMGA1-pseudogenes and cancer.
De Martino M, Forzati F, Arra C, Fusco A, Esposito F. De Martino M, et al. Oncotarget. 2016 May 10;7(19):28724-35. doi: 10.18632/oncotarget.7427. Oncotarget. 2016. PMID: 26895108 Free PMC article. Review.
Here, we concentrate our attention on the pseudogenes of the HMGA1 gene, that codes for the HMGA1a and HMGA1b proteins having a critical role in development and cancer progression. ...
Here, we concentrate our attention on the pseudogenes of the HMGA1 gene, that codes for the HMGA1a and HMGA1b proteins having a criti …
Dynamic and differential in vivo modifications of the isoform HMGA1a and HMGA1b chromatin proteins.
Edberg DD, Adkins JN, Springer DL, Reeves R. Edberg DD, et al. J Biol Chem. 2005 Mar 11;280(10):8961-73. doi: 10.1074/jbc.M407348200. Epub 2004 Dec 11. J Biol Chem. 2005. PMID: 15591590 Free article.
The HMGA1 protooncogene codes for two closely related isoform proteins, HMGA1a and HMGA1b, and causes cancerous cellular transformation when overexpressed in either transgenic mice or "normal" cultured cell lines. ...Although some of the PTMs were the same on both the HMGA …
The HMGA1 protooncogene codes for two closely related isoform proteins, HMGA1a and HMGA1b, and causes cancerous cellular transformati …
Dual role for SUMO E2 conjugase Ubc9 in modulating the transforming and growth-promoting properties of the HMGA1b architectural transcription factor.
Li Y, Lu J, Prochownik EV. Li Y, et al. J Biol Chem. 2007 May 4;282(18):13363-71. doi: 10.1074/jbc.M610919200. Epub 2007 Mar 9. J Biol Chem. 2007. PMID: 17350957 Free article.
Members of the HMGA1 (high mobility group A1) family of architectural transcription factors, HMGA1a and HMGA1b, play important roles in many normal cellular processes and in tumorigenesis. ...Consistent with these findings, endogenous HMGA1 proteins and Ubc9 could be co-im …
Members of the HMGA1 (high mobility group A1) family of architectural transcription factors, HMGA1a and HMGA1b, play important roles …
The High Mobility Group A1 (HMGA1) Transcriptome in Cancer and Development.
Sumter TF, Xian L, Huso T, Koo M, Chang YT, Almasri TN, Chia L, Inglis C, Reid D, Resar LM. Sumter TF, et al. Curr Mol Med. 2016;16(4):353-93. doi: 10.2174/1566524016666160316152147. Curr Mol Med. 2016. PMID: 26980699 Free PMC article. Review.
Chromatin remodeling proteins regulate chromatin structure and high mobility group A (HMGA1) proteins are among the most abundant, nonhistone chromatin remodeling proteins found in cancer cells. These proteins include HMGA1a/HMGA1b isoforms, which result from alternatively …
Chromatin remodeling proteins regulate chromatin structure and high mobility group A (HMGA1) proteins are among the most abundant, nonhiston …
A mass spectrometric study on the in vitro methylation of HMGA1a and HMGA1b proteins by PRMTs: methylation specificity, the effect of binding to AT-rich duplex DNA, and the effect of C-terminal phosphorylation.
Zou Y, Webb K, Perna AD, Zhang Q, Clarke S, Wang Y. Zou Y, et al. Biochemistry. 2007 Jul 3;46(26):7896-906. doi: 10.1021/bi6024897. Epub 2007 Jun 6. Biochemistry. 2007. PMID: 17550233
HMGA1a and HMGA1b are members of one subfamily of non-histone chromosomal high-mobility group (HMG) proteins. ...Here, we investigated the in vitro methylation of recombinant human HMGA1a and HMGA1b proteins by three members of the protein arginine methyltransferase …
HMGA1a and HMGA1b are members of one subfamily of non-histone chromosomal high-mobility group (HMG) proteins. ...Here, we investigate …
Genetics of uterine leiomyomata.
Ligon AH, Morton CC. Ligon AH, et al. Genes Chromosomes Cancer. 2000 Jul;28(3):235-45. Genes Chromosomes Cancer. 2000. PMID: 10862029 Review.
Cytogenetic aberrations involving chromosomes 6, 7, 12, and 14 constitute the major chromosomal abnormalities seen in leiomyomata and have led to the discovery that disruptions or dysregulations of HMGIC and HMGIY contribute to the development of these tumors. Based on the …
Cytogenetic aberrations involving chromosomes 6, 7, 12, and 14 constitute the major chromosomal abnormalities seen in leiomyomata and have l …
330 results