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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 2
1977 4
1978 5
1979 10
1980 2
1981 11
1982 7
1983 6
1984 9
1985 13
1986 8
1987 11
1988 5
1989 7
1990 9
1991 7
1992 12
1993 10
1994 12
1995 12
1996 8
1997 14
1998 13
1999 14
2000 9
2001 10
2002 15
2003 17
2004 13
2005 12
2006 14
2007 12
2008 15
2009 22
2010 11
2011 10
2012 13
2013 22
2014 14
2015 9
2016 12
2017 15
2018 26
2019 35
2020 18
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490 results
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Page 1
HMGB2 is associated with malignancy and regulates Warburg effect by targeting LDHB and FBP1 in breast cancer.
Fu D, Li J, Wei J, Zhang Z, Luo Y, Tan H, Ren C. Fu D, et al. Cell Commun Signal. 2018 Feb 20;16(1):8. doi: 10.1186/s12964-018-0219-0. Cell Commun Signal. 2018. PMID: 29463261 Free PMC article.
BACKGROUND: High-mobility group box 2 (HMGB2) is implicated in tumorigenesis in various cancers. However, the clinical significance of HMGB2 signaling in human breast cancer progression remains unknown. ...Higher HMGB2 expression correlated with larger …
BACKGROUND: High-mobility group box 2 (HMGB2) is implicated in tumorigenesis in various cancers. However, the clinical signifi …
HMGB2 is a negative regulator of telomerase activity in human embryonic stem and progenitor cells.
Kučírek M, Bagherpoor AJ, Jaroš J, Hampl A, Štros M. Kučírek M, et al. FASEB J. 2019 Dec 1;33(12):14307-14324. doi: 10.1096/fj.201901465RRR. Epub 2019 Oct 26. FASEB J. 2019. PMID: 31661640
The impact of HMGB1/2 KD on telomerase transcriptional regulation observed in neuroectodermal cells is partially masked in hESCs by their pluripotent state. ...HMGB2 is a negative regulator of telomerase activity in human embryonic stem and progenitor cells....
The impact of HMGB1/2 KD on telomerase transcriptional regulation observed in neuroectodermal cells is partially masked in hESCs by t …
Involvement of JNK1/2-NF-κBp65 in the regulation of HMGB2 in myocardial ischemia/reperfusion-induced apoptosis in human AC16 cardiomyocytes.
Zhang W, Zhang Y, Ding K, Zhang H, Zhao Q, Liu Z, Xu Y. Zhang W, et al. Biomed Pharmacother. 2018 Oct;106:1063-1071. doi: 10.1016/j.biopha.2018.07.015. Epub 2018 Jul 17. Biomed Pharmacother. 2018. PMID: 30119172
To examine the function and possible mechanism of HMGB2 in I/R-induced cell injury, human AC16 cardiomyocytes transfected with pLVX-Puro-HMGB2 were treated with SP600125 (JNK1/2 inhibitor) or PDTC (NF-κB inhibitor) and that following I/R injury were transfect …
To examine the function and possible mechanism of HMGB2 in I/R-induced cell injury, human AC16 cardiomyocytes transfected with pLVX-P …
HMGB2 Loss upon Senescence Entry Disrupts Genomic Organization and Induces CTCF Clustering across Cell Types.
Zirkel A, Nikolic M, Sofiadis K, Mallm JP, Brackley CA, Gothe H, Drechsel O, Becker C, Altmüller J, Josipovic N, Georgomanolis T, Brant L, Franzen J, Koker M, Gusmao EG, Costa IG, Ullrich RT, Wagner W, Roukos V, Nürnberg P, Marenduzzo D, Rippe K, Papantonis A. Zirkel A, et al. Mol Cell. 2018 May 17;70(4):730-744.e6. doi: 10.1016/j.molcel.2018.03.030. Epub 2018 Apr 26. Mol Cell. 2018. PMID: 29706538 Free article.
Knocking down HMGB2 suffices for senescence-induced CTCF clustering and for loop reshuffling, while ectopically expressing HMGB2 rescues these effects. Our data suggest that HMGB2-mediated genomic reorganization constitutes a primer for the ensuing senescent …
Knocking down HMGB2 suffices for senescence-induced CTCF clustering and for loop reshuffling, while ectopically expressing HMGB2 …
MicroRNA-329 upregulation impairs the HMGB2/β-catenin pathway and regulates cell biological behaviors in melanoma.
Mo Y, Fang RH, Wu J, Si Y, Jia SQ, Li Q, Bai JZ, She XN, Wang JQ. Mo Y, et al. J Cell Physiol. 2019 Dec;234(12):23518-23527. doi: 10.1002/jcp.28920. Epub 2019 Jun 20. J Cell Physiol. 2019. PMID: 31219186
Melanoma tissues and pigmented nevus tissues were collected, where the levels of miR-329 and high-mobility group box 2 (HMGB2) were determined. ...High level of HMGB2 and low miR-329 expression were observed in melanoma tissues. HMGB2 was targeted and …
Melanoma tissues and pigmented nevus tissues were collected, where the levels of miR-329 and high-mobility group box 2 (HMGB2) …
Expression of HMGB2 indicates worse survival of patients and is required for the maintenance of Warburg effect in pancreatic cancer.
Cai X, Ding H, Liu Y, Pan G, Li Q, Yang Z, Liu W. Cai X, et al. Acta Biochim Biophys Sin (Shanghai). 2017 Feb 6;49(2):119-127. doi: 10.1093/abbs/gmw124. Acta Biochim Biophys Sin (Shanghai). 2017. PMID: 28069585
Mammalian high mobility group Bs (HMGBs) are characterized by two tandem HMG box domains followed by a long acidic tail. Recent studies demonstrated that high expression of HMGBs has been found in many cancers, such as prostate, kidney, ovarian, and gastric cancers. ...Our …
Mammalian high mobility group Bs (HMGBs) are characterized by two tandem HMG box domains followed by a long acidic tail. Recent studi …
Elevated hsa-miR-590-3p expression down-regulates HMGB2 expression and contributes to the severity of IgA nephropathy.
Zhai Y, Qi Y, Long X, Dou Y, Liu D, Cheng G, Xiao J, Liu Z, Zhao Z. Zhai Y, et al. J Cell Mol Med. 2019 Nov;23(11):7299-7309. doi: 10.1111/jcmm.14582. Epub 2019 Sep 26. J Cell Mol Med. 2019. PMID: 31557418 Free PMC article.
Our study aimed to provide a deep understanding of IgAN and focused on the dysregulation of hsa-miR-590-3p and its target gene HMGB2 in PBMCs. ...HMGB2 was identified as the target gene of hsa-miR-590-3p. Furtherly, the elderly patients had higher HMGB2 expre …
Our study aimed to provide a deep understanding of IgAN and focused on the dysregulation of hsa-miR-590-3p and its target gene HMGB2 …
HMGB2 regulates satellite-cell-mediated skeletal muscle regeneration through IGF2BP2.
Zhou X, Li M, Huang H, Chen K, Yuan Z, Zhang Y, Nie Y, Chen H, Zhang X, Chen L, Chen Y, Mo D. Zhou X, et al. J Cell Sci. 2016 Nov 15;129(22):4305-4316. doi: 10.1242/jcs.189944. Epub 2016 Sep 26. J Cell Sci. 2016. PMID: 27672022 Free article.
Here, we identified HMGB2 as an essential nuclear transcriptional co-regulator in myogenesis. HMGB2 was highly expressed in undifferentiated myoblasts and regenerating muscle. Knockdown of HMGB2 inhibited myoblast proliferation and stimulated its differentiat …
Here, we identified HMGB2 as an essential nuclear transcriptional co-regulator in myogenesis. HMGB2 was highly expressed in un …
Involvement of microRNA-23b-5p in the promotion of cardiac hypertrophy and dysfunction via the HMGB2 signaling pathway.
Boureima Oumarou D, Ji H, Xu J, Li S, Ruan W, Xiao F, Yu F. Boureima Oumarou D, et al. Biomed Pharmacother. 2019 Aug;116:108977. doi: 10.1016/j.biopha.2019.108977. Epub 2019 May 17. Biomed Pharmacother. 2019. PMID: 31103821 Free article.
HMGB2 expression under conditions of cardiac hypertrophy was detected by western blotting. The biochemical relationship between miR-23b-5p and HMGB2 was verified using a luciferase reporter vector, lentiviral construct comprising the miR-23b-5p mimic sequence, and m …
HMGB2 expression under conditions of cardiac hypertrophy was detected by western blotting. The biochemical relationship between miR-2 …
Early detection of prostate carcinogens by immunohistochemistry of HMGB2.
Suzuki S, Kato H, Fuji S, Naiki T, Naiki-Ito A, Yamashita Y, Takahashi S. Suzuki S, et al. J Toxicol Sci. 2018;43(6):359-367. doi: 10.2131/jts.43.359. J Toxicol Sci. 2018. PMID: 29877212 Free article.
After treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), expression of high-mobility group protein B2 (HMGB2) was up-regulated in rat ventral prostate. To evaluate the applicability of HMGB2 in the early detection of carcinogenicity of che …
After treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), expression of high-mobility group protein B2 (HMGB2 …
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