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Year Number of Results
1976 2
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1979 10
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1983 6
1984 9
1985 13
1986 8
1987 11
1988 5
1989 7
1990 9
1991 7
1992 12
1993 10
1994 12
1995 12
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1997 14
1998 13
1999 14
2000 9
2001 10
2002 15
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2005 12
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2007 12
2008 15
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2019 35
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2023 42
2024 17

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627 results

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Page 1
Structure and Functions of HMGB2 Protein.
Starkova T, Polyanichko A, Tomilin AN, Chikhirzhina E. Starkova T, et al. Int J Mol Sci. 2023 May 5;24(9):8334. doi: 10.3390/ijms24098334. Int J Mol Sci. 2023. PMID: 37176041 Free PMC article. Review.
Despite the high degree of homology, HMGB1 and HMGB2 proteins differ from each other both in structure and functions. ...In this review, we attempted to bring together diverse data about the structure and functions of the HMGB2 protein. The review also describes pos …
Despite the high degree of homology, HMGB1 and HMGB2 proteins differ from each other both in structure and functions. ...In this revi …
HMGB2 is a potential diagnostic marker and therapeutic target for liver fibrosis and cirrhosis.
Huang Y, Liangpunsakul S, Rudraiah S, Ma J, Keshipeddy SK, Wright D, Costa A, Burgess D, Zhang Y, Huda N, Wang L, Yang Z. Huang Y, et al. Hepatol Commun. 2023 Nov 6;7(11):e0299. doi: 10.1097/HC9.0000000000000299. eCollection 2023 Nov 1. Hepatol Commun. 2023. PMID: 37930124 Free PMC article.
METHODS: The carbon tetrachloride (CCl4) induced liver fibrosis mouse model was used. AAV8-Hmgb2 was utilized to overexpress Hmgb2 in the liver, while Hmgb2-/- mice were used for loss of function experiments. ...Deletion of Hmgb2 in Hmgb2-/- mic …
METHODS: The carbon tetrachloride (CCl4) induced liver fibrosis mouse model was used. AAV8-Hmgb2 was utilized to overexpress Hmgb2 …
HMGB2 regulates the differentiation and stemness of exhausted CD8(+) T cells during chronic viral infection and cancer.
Neubert EN, DeRogatis JM, Lewis SA, Viramontes KM, Ortega P, Henriquez ML, Buisson R, Messaoudi I, Tinoco R. Neubert EN, et al. Nat Commun. 2023 Sep 13;14(1):5631. doi: 10.1038/s41467-023-41352-0. Nat Commun. 2023. PMID: 37704621 Free PMC article.
Furthermore, HMGB2 also had a cell-intrinsic function in the differentiation and function of memory CD8(+) T cells after acute viral infection. Our findings show that HMGB2 is a key regulator of CD8(+) T cells and may be an important molecular target for future T ce …
Furthermore, HMGB2 also had a cell-intrinsic function in the differentiation and function of memory CD8(+) T cells after acute viral …
HMGB2 Deficiency Mitigates Abdominal Aortic Aneurysm by Suppressing Ang-II-Caused Ferroptosis and Inflammation via NF-kappabeta Pathway.
Wu H, Chen L, Lu K, Liu Y, Lu W, Jiang J, Weng C. Wu H, et al. Mediators Inflamm. 2023 Dec 19;2023:2157355. doi: 10.1155/2023/2157355. eCollection 2023. Mediators Inflamm. 2023. PMID: 38148870 Free PMC article.
Finally, the mice model of AAA was established to verify the function of HMGB2 in vivo. RESULTS: Increased HMGB2 level was observed in Ang-II-treated VSMCs and Ang-II-induced mice model. ...Moreover, HMGB2 deficiency neutralized the increase of ROS in VSMCs c …
Finally, the mice model of AAA was established to verify the function of HMGB2 in vivo. RESULTS: Increased HMGB2 level was obs …
HMGB2 upregulation promotes the progression of hepatocellular carcinoma cells through the activation of ZEB1/vimentin axis.
Lu K, Zhao T, Yang L, Liu Y, Ruan X, Cui L, Zhang Y. Lu K, et al. J Gastrointest Oncol. 2023 Oct 31;14(5):2178-2191. doi: 10.21037/jgo-23-447. Epub 2023 Oct 24. J Gastrointest Oncol. 2023. PMID: 37969822 Free PMC article.
In cellular and molecular biology experiments, HMGB2 expression was analyzed in HCC cells. HMGB2 knockdown model was constructed by small interfering RNA (siRNA). ...It indicated HMGB2 promotes the proliferation and motility potential of HCC via HMGB2- …
In cellular and molecular biology experiments, HMGB2 expression was analyzed in HCC cells. HMGB2 knockdown model was construct …
Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation.
Jing Y, Jiang X, Ji Q, Wu Z, Wang W, Liu Z, Guillen-Garcia P, Esteban CR, Reddy P, Horvath S, Li J, Geng L, Hu Q, Wang S, Belmonte JCI, Ren J, Zhang W, Qu J, Liu GH. Jing Y, et al. Cell Stem Cell. 2023 Nov 2;30(11):1452-1471.e10. doi: 10.1016/j.stem.2023.09.007. Epub 2023 Oct 12. Cell Stem Cell. 2023. PMID: 37832549
Through decoding the epigenomic landscapes remodeled by overexpressing SOX5, we uncovered its role in resetting the transcription network for geroprotective genes, including HMGB2. Mechanistically, SOX5 binding elevated the enhancer activity of HMGB2 with increased …
Through decoding the epigenomic landscapes remodeled by overexpressing SOX5, we uncovered its role in resetting the transcription network fo …
HMGB2 orchestrates mitotic clonal expansion by binding to the promoter of C/EBPbeta to facilitate adipogenesis.
Chen K, Zhang J, Liang F, Zhu Q, Cai S, Tong X, He Z, Liu X, Chen Y, Mo D. Chen K, et al. Cell Death Dis. 2021 Jul 2;12(7):666. doi: 10.1038/s41419-021-03959-3. Cell Death Dis. 2021. PMID: 34215724 Free PMC article.
However, the underlying mechanism of HMGB2 in adipogenesis remains poorly known. Here, we provide evidence that HMGB2 deficiency in preadipocytes impedes adipogenesis, while overexpression of HMGB2 increases the potential for adipogenic differentiation. ...Co …
However, the underlying mechanism of HMGB2 in adipogenesis remains poorly known. Here, we provide evidence that HMGB2 deficien …
HMGB2 promotes the malignancy of human gastric cancer and indicates poor survival outcome.
Cui G, Cai F, Ding Z, Gao L. Cui G, et al. Hum Pathol. 2019 Feb;84:133-141. doi: 10.1016/j.humpath.2018.09.017. Epub 2018 Oct 5. Hum Pathol. 2019. PMID: 30296520
HMGB2 is an important protein in carcinogenesis. However, little is known about the specific role of HMGB2 in gastric cancer. ...The effect of HMGB2 on cell proliferation, invasion, and glycolysis was examined in vitro. ...
HMGB2 is an important protein in carcinogenesis. However, little is known about the specific role of HMGB2 in gastric cancer. …
HMGB2 regulates satellite-cell-mediated skeletal muscle regeneration through IGF2BP2.
Zhou X, Li M, Huang H, Chen K, Yuan Z, Zhang Y, Nie Y, Chen H, Zhang X, Chen L, Chen Y, Mo D. Zhou X, et al. J Cell Sci. 2016 Nov 15;129(22):4305-4316. doi: 10.1242/jcs.189944. Epub 2016 Sep 26. J Cell Sci. 2016. PMID: 27672022
HMGB2 was highly expressed in undifferentiated myoblasts and regenerating muscle. ...HMGB2 depletion downregulated Myf5 and cyclin A2 at the protein but not mRNA level. ...
HMGB2 was highly expressed in undifferentiated myoblasts and regenerating muscle. ...HMGB2 depletion downregulated Myf5 and cy …
627 results