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Year Number of Results
1989 2
1994 1
1997 16
1998 30
1999 50
2000 83
2001 79
2002 123
2003 178
2004 188
2005 164
2006 73
2007 115
2008 148
2009 161
2010 199
2011 235
2012 266
2013 343
2014 376
2015 440
2016 371
2017 367
2018 448
2019 490
2020 522
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2022 377
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2024 160

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6,001 results

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Page 1
Identification of HMOX1 as a Critical Ferroptosis-Related Gene in Atherosclerosis.
Wu D, Hu Q, Wang Y, Jin M, Tao Z, Wan J. Wu D, et al. Front Cardiovasc Med. 2022 Apr 14;9:833642. doi: 10.3389/fcvm.2022.833642. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 35498043 Free PMC article.
The pro-ferroptotic effect of HMOX1 was validated through cell experiments. Then we conducted a single-gene analysis of HMOX1 and found that high-expression of HMOX1 in atherosclerotic plaques was accompanied by matrix metalloproteinases (MMPs) producing and …
The pro-ferroptotic effect of HMOX1 was validated through cell experiments. Then we conducted a single-gene analysis of HMOX1 …
HMOX1 upregulation promotes ferroptosis in diabetic atherosclerosis.
Meng Z, Liang H, Zhao J, Gao J, Liu C, Ma X, Liu J, Liang B, Jiao X, Cao J, Wang Y. Meng Z, et al. Life Sci. 2021 Nov 1;284:119935. doi: 10.1016/j.lfs.2021.119935. Epub 2021 Sep 8. Life Sci. 2021. PMID: 34508760
A comprehensive bioinformatic assay further identified that ferroptosis, a new type of programmed cell death and HMOX1 (a gene that encodes heme oxygenase), were vital factors in atherosclerotic vascular disease. ...CONCLUSIONS: We demonstrated that HMOX1 upregulati …
A comprehensive bioinformatic assay further identified that ferroptosis, a new type of programmed cell death and HMOX1 (a gene that e …
Donafenib and GSK-J4 Synergistically Induce Ferroptosis in Liver Cancer by Upregulating HMOX1 Expression.
Zheng C, Zhang B, Li Y, Liu K, Wei W, Liang S, Guo H, Ma K, Liu Y, Wang J, Liu L. Zheng C, et al. Adv Sci (Weinh). 2023 Aug;10(22):e2206798. doi: 10.1002/advs.202206798. Epub 2023 Jun 17. Adv Sci (Weinh). 2023. PMID: 37330650 Free PMC article.
Additionally, through cleavage under targets & tagmentation followed by sequencing (CUT&Tag-seq), it is found that the enhancer regions upstream of HMOX1 promoter significantly increased under donafenib and GSK-J4 co-treatment. A chromosome conformation capture ass …
Additionally, through cleavage under targets & tagmentation followed by sequencing (CUT&Tag-seq), it is found that the enhancer regi …
EF24 induces ferroptosis in osteosarcoma cells through HMOX1.
Lin H, Chen X, Zhang C, Yang T, Deng Z, Song Y, Huang L, Li F, Li Q, Lin S, Jin D. Lin H, et al. Biomed Pharmacother. 2021 Apr;136:111202. doi: 10.1016/j.biopha.2020.111202. Epub 2021 Jan 14. Biomed Pharmacother. 2021. PMID: 33453607 Free article.
EF24 significantly increased MDA level, ROS level and intracellular ferric ion level, these effects were significantly attenuated by ferrostatin-1. EF24 upregulated HMOX1 expression in a dose dependent manner, overexpression of HMOX1 facilitated EF24 to induce ferro …
EF24 significantly increased MDA level, ROS level and intracellular ferric ion level, these effects were significantly attenuated by ferrost …
Flavonoid 4,4'-dimethoxychalcone induced ferroptosis in cancer cells by synergistically activating Keap1/Nrf2/HMOX1 pathway and inhibiting FECH.
Yang C, Wang T, Zhao Y, Meng X, Ding W, Wang Q, Liu C, Deng H. Yang C, et al. Free Radic Biol Med. 2022 Aug 1;188:14-23. doi: 10.1016/j.freeradbiomed.2022.06.010. Epub 2022 Jun 11. Free Radic Biol Med. 2022. PMID: 35697292 Free article.
Furthermore, we proved that DMC induced Keap1 degradation via ubiquitin-proteasome system, which led to the nuclear translocation of Nrf2 and upregulated Nrf2 targeted gene HMOX1. FECH inhibition and HMOX1 upregulation resulted in iron overload and triggered ferropt …
Furthermore, we proved that DMC induced Keap1 degradation via ubiquitin-proteasome system, which led to the nuclear translocation of Nrf2 an …
Shikonin and cisplatin synergistically overcome cisplatin resistance of ovarian cancer by inducing ferroptosis via upregulation of HMOX1 to promote Fe(2+) accumulation.
Ni M, Zhou J, Zhu Z, Xu Q, Yin Z, Wang Y, Zheng Z, Zhao H. Ni M, et al. Phytomedicine. 2023 Apr;112:154701. doi: 10.1016/j.phymed.2023.154701. Epub 2023 Feb 4. Phytomedicine. 2023. PMID: 36773431
Accumulation of Fe(2+) was attenuated by siRNA interference of HMOX1. In vivo, combination treatment significantly inhibited the growth of subcutaneous tumors in BALB/c nude mice and increased the expression of ferroptosis-related proteins in tumor tissue. ...Mechanistic a …
Accumulation of Fe(2+) was attenuated by siRNA interference of HMOX1. In vivo, combination treatment significantly inhibited the grow …
Ythdf2 promotes pulmonary hypertension by suppressing Hmox1-dependent anti-inflammatory and antioxidant function in alveolar macrophages.
Hu L, Yu Y, Shen Y, Huang H, Lin D, Wang K, Yu Y, Li K, Cao Y, Wang Q, Sun X, Qiu Z, Wei D, Shen B, Chen J, Fulton D, Ji Y, Wang J, Chen F. Hu L, et al. Redox Biol. 2023 May;61:102638. doi: 10.1016/j.redox.2023.102638. Epub 2023 Feb 15. Redox Biol. 2023. PMID: 36801705 Free PMC article.
Mechanistically, Ythdf2 promoted the degradation of Hmox1 mRNA in a m(6)A dependent manner. Furthermore, an inhibitor of Hmox1 promoted macrophage alternative activation, and reversed the protection from PH seen in Ythdf2(Lyz2 Cre) mice under hypoxic exposure. Toget …
Mechanistically, Ythdf2 promoted the degradation of Hmox1 mRNA in a m(6)A dependent manner. Furthermore, an inhibitor of Hmox1 …
Histone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1alpha/HMOX1 axis.
Shi J, Wang QH, Wei X, Huo B, Ye JN, Yi X, Feng X, Fang ZM, Jiang DS, Ma MJ. Shi J, et al. Mol Med. 2023 Jul 6;29(1):91. doi: 10.1186/s10020-023-00694-7. Mol Med. 2023. PMID: 37415103 Free PMC article.
Furthermore, we found that hypoxia-inducible factor-1alpha (HIF-1alpha)/heme oxygenase 1 (HMOX1) pathway was responsible for the impacts of P300 on ferroptosis of HASMCs. The results of co-immunoprecipitation demonstrated that P300 and P53 competitively bound HIF-1alpha to …
Furthermore, we found that hypoxia-inducible factor-1alpha (HIF-1alpha)/heme oxygenase 1 (HMOX1) pathway was responsible for the impa …
The HMOX1 Pathway as a Promising Target for the Treatment and Prevention of SARS-CoV-2 of 2019 (COVID-19).
Batra N, De Souza C, Batra J, Raetz AG, Yu AM. Batra N, et al. Int J Mol Sci. 2020 Sep 3;21(17):6412. doi: 10.3390/ijms21176412. Int J Mol Sci. 2020. PMID: 32899231 Free PMC article. Review.
The SARS-CoV-2 open reading frame 3 a (ORF3a) protein was found to bind to the human HMOX1 protein at a high confidence through high-throughput screening experiments. ...Here, we review the potential of modulating the HMOX1-ORF3a nexus to regulate the innate immune …
The SARS-CoV-2 open reading frame 3 a (ORF3a) protein was found to bind to the human HMOX1 protein at a high confidence through high- …
HMOX1 promotes lung adenocarcinoma metastasis by affecting macrophages and mitochondrion complexes.
Chen B, Zhang L, Zhou H, Ye W, Luo C, Yang L, Fang N, Tang A. Chen B, et al. Front Oncol. 2022 Aug 12;12:978006. doi: 10.3389/fonc.2022.978006. eCollection 2022. Front Oncol. 2022. PMID: 36033490 Free PMC article.
METHODS: Pan-cancer analysis was first used to identify the metastasis-associated role of HMOX1 in LUAD. HMOX1-related genomic alterations were then investigated. ...CONCLUSIONS: Our analysis elaborates on the role of HMOX1 in LUAD metastasis and identified a …
METHODS: Pan-cancer analysis was first used to identify the metastasis-associated role of HMOX1 in LUAD. HMOX1-related genomic …
6,001 results