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AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and c-Myc pathways.
Ho C, Wang C, Mattu S, Destefanis G, Ladu S, Delogu S, Armbruster J, Fan L, Lee SA, Jiang L, Dombrowski F, Evert M, Chen X, Calvisi DF. Ho C, et al. Hepatology. 2012 Mar;55(3):833-45. doi: 10.1002/hep.24736. Epub 2011 Dec 19. Hepatology. 2012. PMID: 21993994 Free PMC article.
Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma.
Calvisi DF, Wang C, Ho C, Ladu S, Lee SA, Mattu S, Destefanis G, Delogu S, Zimmermann A, Ericsson J, Brozzetti S, Staniscia T, Chen X, Dombrowski F, Evert M. Calvisi DF, et al. Among authors: ho c. Gastroenterology. 2011 Mar;140(3):1071-83. doi: 10.1053/j.gastro.2010.12.006. Epub 2010 Dec 11. Gastroenterology. 2011. PMID: 21147110 Free PMC article.
Hedgehog signaling in human hepatocellular carcinoma.
Patil MA, Zhang J, Ho C, Cheung ST, Fan ST, Chen X. Patil MA, et al. Among authors: ho c. Cancer Biol Ther. 2006 Jan;5(1):111-7. doi: 10.4161/cbt.5.1.2379. Epub 2006 Jan 5. Cancer Biol Ther. 2006. PMID: 16397407
8,598 results