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Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3.
Nature. 2022 Apr;604(7904):184-189. doi: 10.1038/s41586-022-04467-w. Epub 2022 Feb 3.
Nature. 2022.
PMID: 35114687
An Assay for the Seeding of Homotypic Pyrin Domain Filament Transitions.
Hochheiser IV, Geyer M.
Hochheiser IV, et al.
Methods Mol Biol. 2022;2523:197-207. doi: 10.1007/978-1-0716-2449-4_13.
Methods Mol Biol. 2022.
PMID: 35759199
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β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia.
Friker LL, Scheiblich H, Hochheiser IV, Brinkschulte R, Riedel D, Latz E, Geyer M, Heneka MT.
Friker LL, et al. Among authors: hochheiser iv.
Cell Rep. 2020 Mar 17;30(11):3743-3754.e6. doi: 10.1016/j.celrep.2020.02.025.
Cell Rep. 2020.
PMID: 32187546
Free PMC article.
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Directionality of PYD filament growth determined by the transition of NLRP3 nucleation seeds to ASC elongation.
Hochheiser IV, Behrmann H, Hagelueken G, Rodríguez-Alcázar JF, Kopp A, Latz E, Behrmann E, Geyer M.
Hochheiser IV, et al.
Sci Adv. 2022 May 13;8(19):eabn7583. doi: 10.1126/sciadv.abn7583. Epub 2022 May 13.
Sci Adv. 2022.
PMID: 35559676
Free PMC article.
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The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening.
Hartman G, Humphries P, Hughes R, Ho A, Montgomery R, Deshpande A, Mahanta M, Tronnes S, Cowdin S, He X, Liu F, Zhang L, Liu C, Dou D, Li J, Spasic A, Coll R, Marleaux M, Hochheiser IV, Geyer M, Rubin P, Fortney K, Wilhelmsen K.
Hartman G, et al. Among authors: hochheiser iv.
Bioorg Med Chem Lett. 2024 Apr 1;102:129675. doi: 10.1016/j.bmcl.2024.129675. Epub 2024 Feb 28.
Bioorg Med Chem Lett. 2024.
PMID: 38417632
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