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Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs.
Cheng X, Kim JY, Ghafoory S, Duvaci T, Rafiee R, Theobald J, Alborzinia H, Holenya P, Fredebohm J, Merz KH, Mehrabi A, Hafezi M, Saffari A, Eisenbrand G, Hoheisel JD, Wölfl S. Cheng X, et al. Among authors: holenya p. Mol Oncol. 2016 Jun;10(6):806-24. doi: 10.1016/j.molonc.2016.01.008. Epub 2016 Feb 4. Mol Oncol. 2016. PMID: 26887594 Free PMC article.
Real-time monitoring of cisplatin-induced cell death.
Alborzinia H, Can S, Holenya P, Scholl C, Lederer E, Kitanovic I, Wölfl S. Alborzinia H, et al. Among authors: holenya p. PLoS One. 2011;6(5):e19714. doi: 10.1371/journal.pone.0019714. Epub 2011 May 16. PLoS One. 2011. PMID: 21603599 Free PMC article.
Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance.
Nwosu ZC, Piorońska W, Battello N, Zimmer AD, Dewidar B, Han M, Pereira S, Blagojevic B, Castven D, Charlestin V, Holenya P, Lochead J, De La Torre C, Gretz N, Sajjakulnukit P, Zhang L, Ward MH, Marquardt JU, di Magliano MP, Lyssiotis CA, Sleeman J, Wölfl S, Ebert MP, Meyer C, Hofmann U, Dooley S. Nwosu ZC, et al. Among authors: holenya p. EBioMedicine. 2020 Apr;54:102699. doi: 10.1016/j.ebiom.2020.102699. Epub 2020 Apr 21. EBioMedicine. 2020. PMID: 32330875 Free PMC article.
Multimodal Eph/Ephrin signaling controls several phases of urogenital development.
Peuckert C, Aresh B, Holenya P, Adams D, Sreedharan S, Porthin A, Andersson L, Pettersson H, Wölfl S, Klein R, Oxburgh L, Kullander K. Peuckert C, et al. Among authors: holenya p. Kidney Int. 2016 Aug;90(2):373-388. doi: 10.1016/j.kint.2016.04.021. Epub 2016 Jun 22. Kidney Int. 2016. PMID: 27344203 Free article.
24 results