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Common polygenic variation enhances risk prediction for Alzheimer's disease.
Escott-Price V, Sims R, Bannister C, Harold D, Vronskaya M, Majounie E, Badarinarayan N; GERAD/PERADES; IGAP consortia; Morgan K, Passmore P, Holmes C, Powell J, Brayne C, Gill M, Mead S, Goate A, Cruchaga C, Lambert JC, van Duijn C, Maier W, Ramirez A, Holmans P, Jones L, Hardy J, Seshadri S, Schellenberg GD, Amouyel P, Williams J. Escott-Price V, et al. Among authors: holmans p. Brain. 2015 Dec;138(Pt 12):3673-84. doi: 10.1093/brain/awv268. Epub 2015 Oct 21. Brain. 2015. PMID: 26490334 Free PMC article.
Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington's disease are not reflected in mutant Huntingtin inclusion prevalence.
Bayram-Weston Z, Stone TC, Giles P, Elliston L, Janghra N, Higgs GV, Holmans PA, Dunnett SB, Brooks SP, Jones L. Bayram-Weston Z, et al. Among authors: holmans pa. BMC Genomics. 2015 Dec 21;16:1079. doi: 10.1186/s12864-015-2251-4. BMC Genomics. 2015. PMID: 26691352 Free PMC article.
DNA repair pathways underlie a common genetic mechanism modulating onset in polyglutamine diseases.
Bettencourt C, Hensman-Moss D, Flower M, Wiethoff S, Brice A, Goizet C, Stevanin G, Koutsis G, Karadima G, Panas M, Yescas-Gómez P, García-Velázquez LE, Alonso-Vilatela ME, Lima M, Raposo M, Traynor B, Sweeney M, Wood N, Giunti P; SPATAX Network; Durr A, Holmans P, Houlden H, Tabrizi SJ, Jones L. Bettencourt C, et al. Among authors: holmans p. Ann Neurol. 2016 Jun;79(6):983-90. doi: 10.1002/ana.24656. Epub 2016 May 6. Ann Neurol. 2016. PMID: 27044000 Free PMC article.
440 results