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2022 3
2023 119
2024 4

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Page 1
A First-in-Human Phase I Study of Milademetan, an MDM2 Inhibitor, in Patients With Advanced Liposarcoma, Solid Tumors, or Lymphomas.
Gounder MM, Bauer TM, Schwartz GK, Weise AM, LoRusso P, Kumar P, Tao B, Hong Y, Patel P, Lu Y, Lesegretain A, Tirunagaru VG, Xu F, Doebele RC, Hong DS. Gounder MM, et al. J Clin Oncol. 2023 Mar 20;41(9):1714-1724. doi: 10.1200/JCO.22.01285. Epub 2023 Jan 20. J Clin Oncol. 2023. PMID: 36669146 Free PMC article. Clinical Trial.
PURPOSE: This study evaluated the safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of milademetan, a small-molecule murine double minute-2 (MDM2) inhibitor, in patients with advanced cancers. PATIENTS AND METHODS: In this first-in-human phase I study, p …
PURPOSE: This study evaluated the safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of milademetan, a small-molecule …
TRPV3: Structure, Diseases and Modulators.
Su W, Qiao X, Wang W, He S, Liang K, Hong X. Su W, et al. Molecules. 2023 Jan 12;28(2):774. doi: 10.3390/molecules28020774. Molecules. 2023. PMID: 36677834 Free PMC article. Review.
Tofacitinib for the Treatment of Ulcerative Colitis: An Integrated Summary of up to 7.8 Years of Safety Data from the Global Clinical Programme.
Sandborn WJ, D'Haens GR, Sands BE, Panaccione R, Ng SC, Lawendy N, Kulisek N, Modesto I, Guo X, Mundayat R, Su C, Vranic I, Panés J. Sandborn WJ, et al. J Crohns Colitis. 2023 Apr 3;17(3):338-351. doi: 10.1093/ecco-jcc/jjac141. J Crohns Colitis. 2023. PMID: 36124702 Free PMC article. Clinical Trial.
BACKGROUND AND AIMS: Tofacitinib is an oral small molecule Janus kinase [JAK] inhibitor for the treatment of ulcerative colitis. ...IRs [95% confidence intervals] for all tofacitinib doses were: deaths, 0.23 [0.09-0.46]; serious infections, 1.69 [1.26-2.21]; herpes zoster …
BACKGROUND AND AIMS: Tofacitinib is an oral small molecule Janus kinase [JAK] inhibitor for the treatment of ulcerative colitis. ...I …
Biological Immune Mechanism of Retina.
Zhu X, Hong J, Zhou X. Zhu X, et al. Front Biosci (Landmark Ed). 2023 Dec 29;28(12):363. doi: 10.31083/j.fbl2812363. Front Biosci (Landmark Ed). 2023. PMID: 38179761 Free article. Review.
The blood-retinal barrier (BRB) is a well-recognized mechanism that underlies the retina's immunological privilege. The BRB is formed locally by inhibitory molecules that bind to cell membranes, as well as by the suppression of systemic immune responses. ...
The blood-retinal barrier (BRB) is a well-recognized mechanism that underlies the retina's immunological privilege. The BRB is formed locall …
Pharmacological Activity of Cepharanthine.
Liu K, Hong B, Wang S, Lou F, You Y, Hu R, Shafqat A, Fan H, Tong Y. Liu K, et al. Molecules. 2023 Jun 27;28(13):5019. doi: 10.3390/molecules28135019. Molecules. 2023. PMID: 37446681 Free PMC article. Review.
Enhancement of the therapeutic efficacy of mesenchymal stem cell-derived exosomes in osteoarthritis.
Zhang Z, Zhao S, Sun Z, Zhai C, Xia J, Wen C, Zhang Y, Zhang Y. Zhang Z, et al. Cell Mol Biol Lett. 2023 Sep 28;28(1):75. doi: 10.1186/s11658-023-00485-2. Cell Mol Biol Lett. 2023. PMID: 37770821 Free PMC article. Review.
In recent years, mesenchymal stem cells (MSCs) have emerged as a promising therapeutic option for preclinical and clinical palliation of OA. MSC-derived exosomes (MSC-Exos) carrying bioactive molecules of the parental cells, including non-coding RNAs (ncRNAs) and proteins, …
In recent years, mesenchymal stem cells (MSCs) have emerged as a promising therapeutic option for preclinical and clinical palliation of OA. …
BET Bromodomain Inhibitors: Novel Design Strategies and Therapeutic Applications.
To KKW, Xing E, Larue RC, Li PK. To KKW, et al. Molecules. 2023 Mar 29;28(7):3043. doi: 10.3390/molecules28073043. Molecules. 2023. PMID: 37049806 Free PMC article. Review.
The spectacular growth in the clinical development of small-molecule BET inhibitors underscores the interest and importance of this protein family as an anticancer target. ...In this review, we provided an updated summary about the evolution of small-molecule BET in …
The spectacular growth in the clinical development of small-molecule BET inhibitors underscores the interest and importance of this p …
An ischemic area-targeting, peroxynitrite-responsive, biomimetic carbon monoxide nanogenerator for preventing myocardial ischemia-reperfusion injury.
Zhang J, Liu L, Dong Z, Lu X, Hong W, Liu J, Zou X, Gao J, Jiang H, Sun X, Hu K, Yang Y, Ge J, Luo X, Sun A. Zhang J, et al. Bioact Mater. 2023 Jun 25;28:480-494. doi: 10.1016/j.bioactmat.2023.05.017. eCollection 2023 Oct. Bioact Mater. 2023. PMID: 37408796 Free PMC article.
Myocardial ischemia-reperfusion (MI/R) injury is common in patients who undergo revascularization therapy for myocardial infarction, often leading to cardiac dysfunction. Carbon monoxide (CO) has emerged as a therapeutic molecule due to its beneficial properties such as an …
Myocardial ischemia-reperfusion (MI/R) injury is common in patients who undergo revascularization therapy for myocardial infarction, often l …
Nitric Oxide Synthases in Rheumatoid Arthritis.
Huang JB, Chen ZR, Yang SL, Hong FF. Huang JB, et al. Molecules. 2023 May 29;28(11):4414. doi: 10.3390/molecules28114414. Molecules. 2023. PMID: 37298893 Free PMC article. Review.
However, the specific mechanism of RA has not been thoroughly clarified over the past decade. Nitric oxide (NO), a kind of gas messenger molecule with many molecular targets, is demonstrated to have significant roles in histopathology and homeostasis. ...
However, the specific mechanism of RA has not been thoroughly clarified over the past decade. Nitric oxide (NO), a kind of gas messenger …
120 results