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Re-discovery of MS-347a as a fungicide candidate through a new drug discovery platform with a multidrug-sensitive Saccharomyces cerevisiae screening system and the introduction of a global secondary metabolism regulator, laeA gene.
Honma S, Kimishima A, Kimishima A, Honsho M, Kojima H, Tokiwa T, Nishitomi A, Kato S, Kondo N, Araki Y, Takahashi T, Chinen T, Usui T, Fuji SI, Ito K, Asami Y. Honma S, et al. Biosci Biotechnol Biochem. 2024 Apr 25:zbae050. doi: 10.1093/bbb/zbae050. Online ahead of print. Biosci Biotechnol Biochem. 2024. PMID: 38664007
Binding Mode-Based Physicochemical Screening Method Using d-Ala-d-Ala Silica Gel and Chemical Modification Approach to Facilitate Discovery of New Macrolactams, Banglactams A and B, from Nonomuraea bangladeshensis K18-0086.
Kimishima A, Suzuki Y, Kosaka S, Honsho M, Honma S, Tsutsumi H, Inahashi Y, Watanabe Y, Nakashima T, Asami Y, Iwatsuki M. Kimishima A, et al. Among authors: honma s. ACS Omega. 2024 Apr 5;9(15):17415-17422. doi: 10.1021/acsomega.4c00145. eCollection 2024 Apr 16. ACS Omega. 2024. PMID: 38645345 Free PMC article.
PurA is the main target of aurodox, a type III secretion system inhibitor.
Watanabe Y, Haneda T, Kimishima A, Kuwae A, Suga T, Suzuki T, Iwabuchi Y, Honsho M, Honma S, Iwatsuki M, Matsui H, Hanaki H, Kanoh N, Abe A, Asami Y, Ōmura S. Watanabe Y, et al. Among authors: honma s. Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2322363121. doi: 10.1073/pnas.2322363121. Epub 2024 Apr 19. Proc Natl Acad Sci U S A. 2024. PMID: 38640341
722 results