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Long QT syndrome-associated mutations in KCNQ1 and KCNE1 subunits disrupt normal endosomal recycling of IKs channels.
Seebohm G, Strutz-Seebohm N, Ureche ON, Henrion U, Baltaev R, Mack AF, Korniychuk G, Steinke K, Tapken D, Pfeufer A, Kääb S, Bucci C, Attali B, Merot J, Tavare JM, Hoppe UC, Sanguinetti MC, Lang F. Seebohm G, et al. Among authors: hoppe uc. Circ Res. 2008 Dec 5;103(12):1451-7. doi: 10.1161/CIRCRESAHA.108.177360. Epub 2008 Nov 13. Circ Res. 2008. PMID: 19008479
Through modulation of cardiac Ca2+ handling, UCP2 affects cardiac electrophysiology and influences the susceptibility for Ca2+ -mediated arrhythmias.
Larbig R, Reda S, Paar V, Trost A, Leitner J, Weichselbaumer S, Motloch KA, Wernly B, Arrer A, Strauss B, Lichtenauer M, Reitsamer HA, Eckardt L, Seebohm G, Hoppe UC, Motloch LJ. Larbig R, et al. Among authors: hoppe uc. Exp Physiol. 2017 Jun 1;102(6):650-662. doi: 10.1113/EP086209. Exp Physiol. 2017. PMID: 28370799 Free article.
334 results