Howe DL - Search Results

1

Mechanistic insight into 3-deoxy-D-manno-octulosonate-8-phosphate synthase and 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase utilizing phosphorylated monosaccharide analogues.

Howe DL, Sundaram AK, Wu J, Gatti DL, Woodard RW. Howe DL, et al. Biochemistry. 2003 May 6;42(17):4843-54. doi: 10.1021/bi026553z. Biochemistry. 2003. PMID: 12718525

2

Thermotoga maritima 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase: the ancestral eubacterial DAHP synthase?

Wu J, Howe DL, Woodard RW. Wu J, et al. Among authors: howe dl. J Biol Chem. 2003 Jul 25;278(30):27525-31. doi: 10.1074/jbc.M304631200. Epub 2003 May 12. J Biol Chem. 2003. PMID: 12743122 Free article.

3

Probing the potential metal binding site in Escherichia coli 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (phenylalanine-sensitive).

Sundaram AK, Howe DL, Sheflyan GY, Woodard RW. Sundaram AK, et al. Among authors: howe dl. FEBS Lett. 1998 Dec 18;441(2):195-9. doi: 10.1016/s0014-5793(98)01545-2. FEBS Lett. 1998. PMID: 9883883 Free article.

4

Histidine 268 in 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthase plays the same role as histidine 202 in 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase.

Howe DL, Duewel HS, Woodard RW. Howe DL, et al. J Biol Chem. 2000 Dec 22;275(51):40258-65. doi: 10.1074/jbc.M003585200. J Biol Chem. 2000. PMID: 10988284 Free article.

5

Kinetic and mutagenic evidence for the role of histidine residues in the Lycopersicon esculentum 1-aminocyclopropane-1-carboxylic acid oxidase.

Tayeh MA, Howe DL, Salleh HM, Sheflyan GY, Son JK, Woodard RW. Tayeh MA, et al. Among authors: howe dl. J Protein Chem. 1999 Jan;18(1):55-68. doi: 10.1023/a:1020647400034. J Protein Chem. 1999. PMID: 10071929 Free article.

6

Identification of human UGT2B7 as the major isoform involved in the O-glucuronidation of chloramphenicol.

Chen M, LeDuc B, Kerr S, Howe D, Williams DA. Chen M, et al. Drug Metab Dispos. 2010 Mar;38(3):368-75. doi: 10.1124/dmd.109.029900. Epub 2009 Dec 11. Drug Metab Dispos. 2010. PMID: 20008037

7

Identification and characterization of two chloramphenicol glucuronides from the in vitro glucuronidation of chloramphenicol in human liver microsomes.

Chen M, Howe D, Leduc B, Kerr S, Williams DA. Chen M, et al. Xenobiotica. 2007 Sep;37(9):954-71. doi: 10.1080/00498250701620734. Xenobiotica. 2007. PMID: 17896323

8

In vitro and in vivo isotope effects with hepatitis C protease inhibitors: enhanced plasma exposure of deuterated telaprevir versus telaprevir in rats.

Maltais F, Jung YC, Chen M, Tanoury J, Perni RB, Mani N, Laitinen L, Huang H, Liao S, Gao H, Tsao H, Block E, Ma C, Shawgo RS, Town C, Brummel CL, Howe D, Pazhanisamy S, Raybuck S, Namchuk M, Bennani YL. Maltais F, et al. J Med Chem. 2009 Dec 24;52(24):7993-8001. doi: 10.1021/jm901023f. J Med Chem. 2009. PMID: 19894743

9

Method for rapid metabolite profiling of drug candidates in fresh hepatocytes using liquid chromatography coupled with a hybrid quadrupole linear ion trap.

Gao H, Materne OL, Howe DL, Brummel CL. Gao H, et al. Among authors: howe dl. Rapid Commun Mass Spectrom. 2007;21(22):3683-93. doi: 10.1002/rcm.3257. Rapid Commun Mass Spectrom. 2007. PMID: 17937450

10

Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases.

Farmer LJ, Ledeboer MW, Hoock T, Arnost MJ, Bethiel RS, Bennani YL, Black JJ, Brummel CL, Chakilam A, Dorsch WA, Fan B, Cochran JE, Halas S, Harrington EM, Hogan JK, Howe D, Huang H, Jacobs DH, Laitinen LM, Liao S, Mahajan S, Marone V, Martinez-Botella G, McCarthy P, Messersmith D, Namchuk M, Oh L, Penney MS, Pierce AC, Raybuck SA, Rugg A, Salituro FG, Saxena K, Shannon D, Shlyakter D, Swenson L, Tian SK, Town C, Wang J, Wang T, Wannamaker MW, Winquist RJ, Zuccola HJ. Farmer LJ, et al. J Med Chem. 2015 Sep 24;58(18):7195-216. doi: 10.1021/acs.jmedchem.5b00301. Epub 2015 Sep 10. J Med Chem. 2015. PMID: 26230873

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