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2002 1
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2014 7
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53 results

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Page 1
Identification of HPCAL1 as a specific autophagy receptor involved in ferroptosis.
Chen X, Song X, Li J, Zhang R, Yu C, Zhou Z, Liu J, Liao S, Klionsky DJ, Kroemer G, Liu J, Tang D, Kang R. Chen X, et al. Autophagy. 2023 Jan;19(1):54-74. doi: 10.1080/15548627.2022.2059170. Epub 2022 Apr 10. Autophagy. 2023. PMID: 35403545 Free PMC article.
HPCAL1-dependent CDH2 depletion increases susceptibility to ferroptotic death by reducing membrane tension and favoring lipid peroxidation. ...An unbiased drug screening campaign involving 4208 small molecule compounds led to the identification of a ferroptosis inhibitor t …
HPCAL1-dependent CDH2 depletion increases susceptibility to ferroptotic death by reducing membrane tension and favoring lipid peroxid …
HPCAL1 is a novel driver of autophagy-dependent ferroptosis.
Wang L, Li Q, Liu H, Li L. Wang L, et al. J Zhejiang Univ Sci B. 2023 Nov 15;24(11):1053-1056. doi: 10.1631/jzus.B2300241. J Zhejiang Univ Sci B. 2023. PMID: 37961807 Free PMC article.
,,1(HPCAL1)HPCAL12(CDH2),,iHPCAL1HPCAL1,Erastin,HPCAL1,HPCAL1...
,,1(HPCAL1)HPCAL12(CDH2),,iHPCAL1HPCAL1,Erastin,HPCAL1,HPCAL1...
HPCAL1 promotes glioblastoma proliferation via activation of Wnt/beta-catenin signalling pathway.
Zhang D, Liu X, Xu X, Xu J, Yi Z, Shan B, Liu B. Zhang D, et al. J Cell Mol Med. 2019 May;23(5):3108-3117. doi: 10.1111/jcmm.14083. Epub 2019 Mar 6. J Cell Mol Med. 2019. PMID: 30843345 Free PMC article.
Ectopic expression of HPCAL1 promoted proliferation of cells. Exhaustion of HPCAL1 inhibited cell growth not only in vivo, but also in vitro. ...Furthermore, the phosphorylation of ERK was decreased in the cells with HPCAL1 knockdown, while it was promoted vi …
Ectopic expression of HPCAL1 promoted proliferation of cells. Exhaustion of HPCAL1 inhibited cell growth not only in vivo, but …
Expressional and prognostic value of HPCAL1 in cholangiocarcinoma via integrated bioinformatics analyses and experiments.
Ma M, Zeng G, Li J, Liang J, Huang L, Chen J, Lai J. Ma M, et al. Cancer Med. 2023 Jan;12(1):824-836. doi: 10.1002/cam4.4897. Epub 2022 May 29. Cancer Med. 2023. PMID: 35645147 Free PMC article.
BACKGROUND: Hippocalcin-like 1 (HPCAL1) is involved in the development of several cancer types. However, our understanding of the HPCAL1 activity in cholangiocarcinoma (CCA) remains limited. ...The prognostic value of HPCAL1 overexpression in the validation c …
BACKGROUND: Hippocalcin-like 1 (HPCAL1) is involved in the development of several cancer types. However, our understanding of the …
Hippocalcin-Like 1 blunts liver lipid metabolism to suppress tumorigenesis via directly targeting RUVBL1-mTOR signaling.
Chen T, Yuan Z, Lei Z, Duan J, Xue J, Lu T, Yan G, Zhang L, Liu Y, Li Q, Zhang Y. Chen T, et al. Theranostics. 2022 Oct 24;12(17):7450-7464. doi: 10.7150/thno.75936. eCollection 2022. Theranostics. 2022. PMID: 36438486 Free PMC article.
The role of Hpcal1 in liver tumorigenesis and its response to mTORi was assessed by CCK-8 measurements, colony formation assay and in mouse model. ...Genetic loss of HPCAL1 rendered HCC mTORC1-addicted and sensitive to mTORi AZD-8055 in vitro and in vivo. ...
The role of Hpcal1 in liver tumorigenesis and its response to mTORi was assessed by CCK-8 measurements, colony formation assay and in …
Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction and Coronary Heart Disease.
Agha G, Mendelson MM, Ward-Caviness CK, Joehanes R, Huan T, Gondalia R, Salfati E, Brody JA, Fiorito G, Bressler J, Chen BH, Ligthart S, Guarrera S, Colicino E, Just AC, Wahl S, Gieger C, Vandiver AR, Tanaka T, Hernandez DG, Pilling LC, Singleton AB, Sacerdote C, Krogh V, Panico S, Tumino R, Li Y, Zhang G, Stewart JD, Floyd JS, Wiggins KL, Rotter JI, Multhaup M, Bakulski K, Horvath S, Tsao PS, Absher DM, Vokonas P, Hirschhorn J, Fallin MD, Liu C, Bandinelli S, Boerwinkle E, Dehghan A, Schwartz JD, Psaty BM, Feinberg AP, Hou L, Ferrucci L, Sotoodehnia N, Matullo G, Peters A, Fornage M, Assimes TL, Whitsel EA, Levy D, Baccarelli AA. Agha G, et al. Circulation. 2019 Aug 20;140(8):645-657. doi: 10.1161/CIRCULATIONAHA.118.039357. Epub 2019 Aug 19. Circulation. 2019. PMID: 31424985 Free PMC article.
These CpGs map to genes with key roles in calcium regulation (ATP2B2, CASR, GUCA1B, HPCAL1), and genes identified in genome- and epigenome-wide studies of serum calcium (CASR), serum calcium-related risk of CHD (CASR), coronary artery calcified plaque (PTPRN2), and kidney …
These CpGs map to genes with key roles in calcium regulation (ATP2B2, CASR, GUCA1B, HPCAL1), and genes identified in genome- and epig …
DCLK1 autoinhibition and activation in tumorigenesis.
Cheng L, Yang Z, Guo W, Wu C, Liang S, Tong A, Cao Z, Thorne RF, Yang SY, Yu Y, Chen Q. Cheng L, et al. Innovation (Camb). 2021 Nov 26;3(1):100191. doi: 10.1016/j.xinn.2021.100191. eCollection 2022 Jan 25. Innovation (Camb). 2021. PMID: 34977835 Free PMC article.
Here we determined the first DCLK1 kinase structure in the autoinhibited state and identified the neuronal calcium sensor HPCAL1 as an activator of DCLK1. The C-terminal AID functions to block the ATP-binding site and is competitive with ATP. HPCAL1 binds directly t …
Here we determined the first DCLK1 kinase structure in the autoinhibited state and identified the neuronal calcium sensor HPCAL1 as a …
Autophagy-Dependent Ferroptosis in Cancer.
Chen F, Cai X, Kang R, Liu J, Tang D. Chen F, et al. Antioxid Redox Signal. 2023 Jul;39(1-3):79-101. doi: 10.1089/ars.2022.0202. Epub 2023 Mar 9. Antioxid Redox Signal. 2023. PMID: 36734418 Review.
Several upstream autophagosome regulators (e.g., TMEM164), downstream autophagy receptors (e.g., HPCAL1), or danger signals (e.g., DCN) are selectively required for ferroptosis-related autophagy, but not for starvation-induced autophagy. ...
Several upstream autophagosome regulators (e.g., TMEM164), downstream autophagy receptors (e.g., HPCAL1), or danger signals (e.g., DC …
Hippocalcin-like 1 is a key regulator of LDHA activation that promotes the growth of non-small cell lung carcinoma.
Wang X, Xie X, Zhang Y, Ma F, Pang M, Laster KV, Li X, Liu K, Dong Z, Kim DJ. Wang X, et al. Cell Oncol (Dordr). 2022 Feb;45(1):179-191. doi: 10.1007/s13402-022-00661-0. Epub 2022 Jan 31. Cell Oncol (Dordr). 2022. PMID: 35102488
HPCAL1 knockdown also inhibited NSCLC cell growth and patient-derived NSCLC tumor growth in vivo. ...Additionally, rescued cells expressing wild-type or mutant LDHA in HPCAL1 knockdown cells suggest that LDHA may serve as the main substrate of HPCAL1. ...
HPCAL1 knockdown also inhibited NSCLC cell growth and patient-derived NSCLC tumor growth in vivo. ...Additionally, rescued cells expr …
Mutations that disrupt PHOXB interaction with the neuronal calcium sensor HPCAL1 impede cellular differentiation in neuroblastoma.
Wang W, Zhong Q, Teng L, Bhatnagar N, Sharma B, Zhang X, Luther W 2nd, Haynes LP, Burgoyne RD, Vidal M, Volchenboum S, Hill DE, George RE. Wang W, et al. Oncogene. 2014 Jun 19;33(25):3316-24. doi: 10.1038/onc.2013.290. Epub 2013 Jul 22. Oncogene. 2014. PMID: 23873030 Free PMC article.
We demonstrate that both WT PHOX2B and the neuroblastoma-associated R100L missense and the CCHS-associated alanine expansion variants induce nuclear translocation of HPCAL1 in a Ca(2+)-independent manner, while the neuroblastoma-associated 676delG frameshift and K155X trun …
We demonstrate that both WT PHOX2B and the neuroblastoma-associated R100L missense and the CCHS-associated alanine expansion variants induce …
53 results