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The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1.
Hum Mol Genet. 2008 Feb 15;17(4):478-89. doi: 10.1093/hmg/ddm325. Epub 2007 Nov 7.
Hum Mol Genet. 2008.
PMID: 17989064
Free article.
The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells.
Brun T, Duhamel DL, Hu He KH, Wollheim CB, Gauthier BR.
Brun T, et al. Among authors: hu he kh.
Oncogene. 2007 Jun 21;26(29):4261-71. doi: 10.1038/sj.onc.1210205. Epub 2007 Jan 29.
Oncogene. 2007.
PMID: 17260022
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In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice.
Hu He KH, Lorenzo PI, Brun T, Jimenez Moreno CM, Aeberhard D, Vallejo Ortega J, Cornu M, Thorel F, Gjinovci A, Thorens B, Herrera PL, Meda P, Wollheim CB, Gauthier BR.
Hu He KH, et al.
Diabetes. 2011 Jun;60(6):1705-15. doi: 10.2337/db10-1102. Epub 2011 Apr 26.
Diabetes. 2011.
PMID: 21521872
Free PMC article.
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