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The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages.
Huang Z, Liang N, Goñi S, Damdimopoulos A, Wang C, Ballaire R, Jager J, Niskanen H, Han H, Jakobsson T, Bracken AP, Aouadi M, Venteclef N, Kaikkonen MU, Fan R, Treuter E. Huang Z, et al. Mol Cell. 2021 Mar 4;81(5):953-968.e9. doi: 10.1016/j.molcel.2020.12.040. Epub 2021 Jan 26. Mol Cell. 2021. PMID: 33503407 Free article.
Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes.
Fan R, Toubal A, Goñi S, Drareni K, Huang Z, Alzaid F, Ballaire R, Ancel P, Liang N, Damdimopoulos A, Hainault I, Soprani A, Aron-Wisnewsky J, Foufelle F, Lawrence T, Gautier JF, Venteclef N, Treuter E. Fan R, et al. Among authors: huang z. Nat Med. 2016 Jul;22(7):780-91. doi: 10.1038/nm.4114. Epub 2016 Jun 6. Nat Med. 2016. PMID: 27270589
G protein pathway suppressor 2 (GPS2) links inflammation and cholesterol efflux by controlling lipopolysaccharide-induced ATP-binding cassette transporter A1 expression in macrophages.
Huang Z, Liang N, Damdimopoulos A, Fan R, Treuter E. Huang Z, et al. FASEB J. 2019 Feb;33(2):1631-1643. doi: 10.1096/fj.201801123R. Epub 2018 Aug 28. FASEB J. 2019. PMID: 30153049
Because GPS2 expression is down-regulated in some humans with obese and type 2 diabetes, the macrophage GPS-2/ABC-A1 pathway could be altered and contribute to atherogenesis.-Huang, Z., Liang, N., Damdimopoulos, A., Fan, R., Treuter, E. G protein pathway suppressor …
Because GPS2 expression is down-regulated in some humans with obese and type 2 diabetes, the macrophage GPS-2/ABC-A1 pathway could be altere …
Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα.
Liang N, Damdimopoulos A, Goñi S, Huang Z, Vedin LL, Jakobsson T, Giudici M, Ahmed O, Pedrelli M, Barilla S, Alzaid F, Mendoza A, Schröder T, Kuiper R, Parini P, Hollenberg A, Lefebvre P, Francque S, Van Gaal L, Staels B, Venteclef N, Treuter E, Fan R. Liang N, et al. Among authors: huang z. Nat Commun. 2019 Apr 11;10(1):1684. doi: 10.1038/s41467-019-09524-z. Nat Commun. 2019. PMID: 30975991 Free PMC article.
Plaque Evaluation by Ultrasound and Transcriptomics Reveals BCLAF1 as a Regulator of Smooth Muscle Cell Lipid Transdifferentiation in Atherosclerosis.
Rykaczewska U, Zhao Q, Saliba-Gustafsson P, Lengquist M, Kronqvist M, Bergman O, Huang Z, Lund K, Waden K, Pons Vila Z, Caidahl K, Skogsberg J, Vukojevic V, Lindeman JHN, Roy J, Hansson GK, Treuter E, Leeper NJ, Eriksson P, Ehrenborg E, Razuvaev A, Hedin U, Matic L. Rykaczewska U, et al. Among authors: huang z. Arterioscler Thromb Vasc Biol. 2022 May;42(5):659-676. doi: 10.1161/ATVBAHA.121.317018. Epub 2022 Mar 24. Arterioscler Thromb Vasc Biol. 2022. PMID: 35321563 Free article.
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