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IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine 'bystander senescence'.
Hubackova S, Krejcikova K, Bartek J, Hodny Z. Hubackova S, et al. Aging (Albany NY). 2012 Dec;4(12):932-51. doi: 10.18632/aging.100520. Aging (Albany NY). 2012. PMID: 23385065 Free PMC article.
Cytokine expression and signaling in drug-induced cellular senescence.
Novakova Z, Hubackova S, Kosar M, Janderova-Rossmeislova L, Dobrovolna J, Vasicova P, Vancurova M, Horejsi Z, Hozak P, Bartek J, Hodny Z. Novakova Z, et al. Oncogene. 2010 Jan 14;29(2):273-84. doi: 10.1038/onc.2009.318. Epub 2009 Oct 5. Oncogene. 2010. PMID: 19802007
Cytokines shape chemotherapy-induced and 'bystander' senescence.
Hodny Z, Hubackova S, Bartek J. Hodny Z, et al. Aging (Albany NY). 2010 Jul;2(7):375-6. doi: 10.18632/aging.100171. Aging (Albany NY). 2010. PMID: 20631421 Free PMC article. No abstract available.
Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling.
Hubackova S, Novakova Z, Krejcikova K, Kosar M, Dobrovolna J, Duskova P, Hanzlikova H, Vancurova M, Barath P, Bartek J, Hodny Z. Hubackova S, et al. Cell Cycle. 2010 Aug 1;9(15):3085-99. doi: 10.4161/cc.9.15.12521. Epub 2010 Aug 26. Cell Cycle. 2010. PMID: 20699642
Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a).
Kosar M, Bartkova J, Hubackova S, Hodny Z, Lukas J, Bartek J. Kosar M, et al. Cell Cycle. 2011 Feb 1;10(3):457-68. doi: 10.4161/cc.10.3.14707. Epub 2011 Feb 1. Cell Cycle. 2011. PMID: 21248468
Cytokine-induced 'bystander' senescence in DDR and immuno-surveillance.
Hodny Z, Hubackova S, Bartek J. Hodny Z, et al. Oncotarget. 2013 Oct;4(10):1552-3. doi: 10.18632/oncotarget.1487. Oncotarget. 2013. PMID: 24145286 Free PMC article. No abstract available.
Radiotherapy-induced plasticity of prostate cancer mobilizes stem-like non-adherent, Erk signaling-dependent cells.
Kyjacova L, Hubackova S, Krejcikova K, Strauss R, Hanzlikova H, Dzijak R, Imrichova T, Simova J, Reinis M, Bartek J, Hodny Z. Kyjacova L, et al. Cell Death Differ. 2015 Jun;22(6):898-911. doi: 10.1038/cdd.2014.97. Epub 2014 Jul 11. Cell Death Differ. 2015. PMID: 25012501 Free PMC article.
TGF-β/NF1/Smad4-mediated suppression of ANT2 contributes to oxidative stress in cellular senescence.
Kretova M, Sabova L, Hodny Z, Bartek J, Kollarovic G, Nelson BD, Hubackova S, Luciakova K. Kretova M, et al. Cell Signal. 2014 Dec;26(12):2903-11. doi: 10.1016/j.cellsig.2014.08.029. Epub 2014 Sep 16. Cell Signal. 2014. PMID: 25220407
IFNγ induces oxidative stress, DNA damage and tumor cell senescence via TGFβ/SMAD signaling-dependent induction of Nox4 and suppression of ANT2.
Hubackova S, Kucerova A, Michlits G, Kyjacova L, Reinis M, Korolov O, Bartek J, Hodny Z. Hubackova S, et al. Oncogene. 2016 Mar 10;35(10):1236-49. doi: 10.1038/onc.2015.162. Epub 2015 May 18. Oncogene. 2016. PMID: 25982278
While cytokines such as tumor necrosis factor-alpha (TNFα) and interferon gamma (IFNγ) are important components of senescence-associated secretome and induce senescence in, for example, mouse pancreatic β-cancer cell model, their downstream signaling pathway(s) and links w …
While cytokines such as tumor necrosis factor-alpha (TNFα) and interferon gamma (IFNγ) are important components of senescence-associated sec …
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