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Conformational flexibility of HIV-1 envelope glycoproteins modulates transmitted / founder sensitivity to broadly neutralizing antibodies.
Parthasarathy D, Pothula KR, Dam KA, Ratnapriya S, Benet HC, Parsons R, Huang X, Sammour S, Janowska K, Harris M, Sacco S, Sodroski J, Bridges MD, Hubbell WL, Acharya P, Herschhorn A. Parthasarathy D, et al. Among authors: hubbell wl. bioRxiv [Preprint]. 2023 Dec 5:2023.09.13.557082. doi: 10.1101/2023.09.13.557082. bioRxiv. 2023. PMID: 37745449 Free PMC article. Preprint.
Ligand efficacy modulates conformational dynamics of the µ-opioid receptor.
Zhao J, Elgeti M, O'Brien ES, Sár CP, Ei Daibani A, Heng J, Sun X, White E, Che T, Hubbell WL, Kobilka BK, Chen C. Zhao J, et al. Among authors: hubbell wl. Nature. 2024 May;629(8011):474-480. doi: 10.1038/s41586-024-07295-2. Epub 2024 Apr 10. Nature. 2024. PMID: 38600384 Free PMC article.
Lipid bilayer induces contraction of the denatured state ensemble of a helical-bundle membrane protein.
Gaffney KA, Guo R, Bridges MD, Muhammednazaar S, Chen D, Kim M, Yang Z, Schilmiller AL, Faruk NF, Peng X, Jones AD, Kim KH, Sun L, Hubbell WL, Sosnick TR, Hong H. Gaffney KA, et al. Among authors: hubbell wl. Proc Natl Acad Sci U S A. 2022 Jan 4;119(1):e2109169119. doi: 10.1073/pnas.2109169119. Proc Natl Acad Sci U S A. 2022. PMID: 34969836 Free PMC article.
DEER Analysis of GPCR Conformational Heterogeneity.
Elgeti M, Hubbell WL. Elgeti M, et al. Among authors: hubbell wl. Biomolecules. 2021 May 22;11(6):778. doi: 10.3390/biom11060778. Biomolecules. 2021. PMID: 34067265 Free PMC article. Review.
An Eight Amino Acid Segment Controls Oligomerization and Preferred Conformation of the two Non-visual Arrestins.
Chen Q, Zhuo Y, Sharma P, Perez I, Francis DJ, Chakravarthy S, Vishnivetskiy SA, Berndt S, Hanson SM, Zhan X, Brooks EK, Altenbach C, Hubbell WL, Klug CS, Iverson TM, Gurevich VV. Chen Q, et al. Among authors: hubbell wl. J Mol Biol. 2021 Feb 19;433(4):166790. doi: 10.1016/j.jmb.2020.166790. Epub 2020 Dec 31. J Mol Biol. 2021. PMID: 33387531 Free PMC article.
244 results