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Year Number of Results
2005 1
2010 1
2011 1
2013 2
2014 2
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2018 1
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2023 1
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11 results

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Page 1
Assessment of Ki67 in breast cancer: recommendations from the International Ki67 in Breast Cancer working group.
Dowsett M, Nielsen TO, A'Hern R, Bartlett J, Coombes RC, Cuzick J, Ellis M, Henry NL, Hugh JC, Lively T, McShane L, Paik S, Penault-Llorca F, Prudkin L, Regan M, Salter J, Sotiriou C, Smith IE, Viale G, Zujewski JA, Hayes DF; International Ki-67 in Breast Cancer Working Group. Dowsett M, et al. J Natl Cancer Inst. 2011 Nov 16;103(22):1656-64. doi: 10.1093/jnci/djr393. Epub 2011 Sep 29. J Natl Cancer Inst. 2011. PMID: 21960707 Free PMC article.
Uncontrolled proliferation is a hallmark of cancer. In breast cancer, immunohistochemical assessment of the proportion of cells staining for the nuclear antigen Ki67 has become the most widely used method for comparing proliferation between tumor samples. ...
Uncontrolled proliferation is a hallmark of cancer. In breast cancer, immunohistochemical assessment of the proportion of cells stain …
Multiple myeloma metabolism - a treasure trove of therapeutic targets?
Roman-Trufero M, Auner HW, Edwards CM. Roman-Trufero M, et al. Front Immunol. 2022 Aug 22;13:897862. doi: 10.3389/fimmu.2022.897862. eCollection 2022. Front Immunol. 2022. PMID: 36072593 Free PMC article. Review.
Here, we provide a concise and introductory discussion of major metabolic hallmarks of plasma cells and myeloma cells, their roles in myeloma development and progression, and how they could be exploited for therapeutic purposes. ...
Here, we provide a concise and introductory discussion of major metabolic hallmarks of plasma cells and myeloma cells, their roles in …
Arthralgia resolution rate following chikungunya virus infection.
O'Driscoll M, Salje H, Chang AY, Watson H. O'Driscoll M, et al. Int J Infect Dis. 2021 Nov;112:1-7. doi: 10.1016/j.ijid.2021.08.066. Epub 2021 Sep 4. Int J Infect Dis. 2021. PMID: 34492392 Free PMC article. Review.
BACKGROUND: Arthralgia, persistent pain or stiffness of the joints, is the hallmark symptom of chronic chikungunya virus (CHIKV) disease. Associated with significant disability and reduced quality of life, arthralgia can persist for many months following CHIKV infection. . …
BACKGROUND: Arthralgia, persistent pain or stiffness of the joints, is the hallmark symptom of chronic chikungunya virus (CHIKV) dise …
Therapeutic Targeting of DNA Damage Repair in the Era of Precision Oncology and Immune Checkpoint Inhibitors.
Clark CA, Yang ES. Clark CA, et al. J Immunother Precis Oncol. 2022 Dec 2;6(1):31-49. doi: 10.36401/JIPO-22-15. eCollection 2023 Feb. J Immunother Precis Oncol. 2022. PMID: 36751656 Free PMC article. Review.
Cancer manifestation is a multistep process involving accumulation of various genetic and epigenetic changes that results in oncogenic "hallmarks of cancer" processes including genomic instability. Exploitation of aberrant DNA-damage response (DDR) mechanisms in cancer is …
Cancer manifestation is a multistep process involving accumulation of various genetic and epigenetic changes that results in oncogenic "h …
Transient cooling episodes during Cretaceous Oceanic Anoxic Events with special reference to OAE 1a (Early Aptian).
Jenkyns HC. Jenkyns HC. Philos Trans A Math Phys Eng Sci. 2018 Oct 13;376(2130):20170073. doi: 10.1098/rsta.2017.0073. Philos Trans A Math Phys Eng Sci. 2018. PMID: 30177559 Free PMC article. Review.
Widely distributed deposition of marine organic matter, the hallmark of OAEs, and intensified silicate weathering in response to a globally accelerated hydrological cycle and/or reaction of seawater with freshly extruded basalt, are both potential mechanisms whereby the co …
Widely distributed deposition of marine organic matter, the hallmark of OAEs, and intensified silicate weathering in response to a gl …
Effects of testosterone on Type 2 diabetes and components of the metabolic syndrome.
Jones TH. Jones TH. J Diabetes. 2010 Sep;2(3):146-56. doi: 10.1111/j.1753-0407.2010.00085.x. J Diabetes. 2010. PMID: 20923480 Free article. Review.
Observational and experimental data suggest that testosterone treatment improves a number of hallmark features of T2DM and metabolic syndrome, namely insulin resistance, obesity, dyslipidemia, and sexual dysfunction. ...
Observational and experimental data suggest that testosterone treatment improves a number of hallmark features of T2DM and metabolic …
Development of P301S tau seeded organotypic hippocampal slice cultures to study potential therapeutics.
McCarthy JM, Virdee J, Brown J, Ursu D, Ahmed Z, Cavallini A, Nuthall HN. McCarthy JM, et al. Sci Rep. 2021 May 13;11(1):10309. doi: 10.1038/s41598-021-89230-3. Sci Rep. 2021. PMID: 33986302 Free PMC article.
Intracellular tau inclusions are a pathological hallmark of Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration and other sporadic neurodegenerative tauopathies. ...
Intracellular tau inclusions are a pathological hallmark of Alzheimer's disease, progressive supranuclear palsy, corticobasal degener …
Viral delivery of C9orf72 hexanucleotide repeat expansions in mice leads to repeat-length-dependent neuropathology and behavioural deficits.
Herranz-Martin S, Chandran J, Lewis K, Mulcahy P, Higginbottom A, Walker C, Valenzuela IMY, Jones RA, Coldicott I, Iannitti T, Akaaboune M, El-Khamisy SF, Gillingwater TH, Shaw PJ, Azzouz M. Herranz-Martin S, et al. Dis Model Mech. 2017 Jul 1;10(7):859-868. doi: 10.1242/dmm.029892. Epub 2017 May 26. Dis Model Mech. 2017. PMID: 28550099 Free PMC article.
Two major pathologies stemming from the hexanucleotide RNA expansions (HREs) have been identified in postmortem tissue: intracellular RNA foci and repeat-associated non-ATG dependent (RAN) dipeptides, although it is unclear how these and other hallmarks of disease contribu …
Two major pathologies stemming from the hexanucleotide RNA expansions (HREs) have been identified in postmortem tissue: intracellular RNA fo …
Expression of V1A and GRP receptors leads to cellular transformation and increased sensitivity to substance-P analogue-induced growth inhibition.
MacKinnon AC, Tufail-Hanif U, Lucas CD, Jodrell D, Haslett C, Sethi T. MacKinnon AC, et al. Br J Cancer. 2005 Feb 14;92(3):522-31. doi: 10.1038/sj.bjc.6602366. Br J Cancer. 2005. PMID: 15685238 Free PMC article.
Neuropeptides particularly arginine vasopressin (AVP) and gastrin-releasing peptide (GRP) act as autocrine and paracrine growth factors and the expression of these and their receptors are a hallmark of the disease. Substance-P analogues including [D-Arg1,D-Phe5,D-Trp7,9,Le …
Neuropeptides particularly arginine vasopressin (AVP) and gastrin-releasing peptide (GRP) act as autocrine and paracrine growth factors and …
Purification and biological characterization of soluble, recombinant mouse IFNβ expressed in insect cells.
Stifter SA, Gould JA, Mangan NE, Reid HH, Rossjohn J, Hertzog PJ, de Weerd NA. Stifter SA, et al. Protein Expr Purif. 2014 Feb;94:7-14. doi: 10.1016/j.pep.2013.10.019. Epub 2013 Nov 6. Protein Expr Purif. 2014. PMID: 24211771
Recombinant murine IFNbeta produced by this method was natively folded and demonstrated hallmark type I interferon biological effects including antiviral and anti-proliferative activities, and induced genes characteristic of IFNbeta activity in vivo. ...
Recombinant murine IFNbeta produced by this method was natively folded and demonstrated hallmark type I interferon biological effects …
11 results