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Impaired hepatitis C virus (HCV)-specific effector CD8+ T cells undergo massive apoptosis in the peripheral blood during acute HCV infection and in the liver during the chronic phase of infection.
Radziewicz H, Ibegbu CC, Hon H, Osborn MK, Obideen K, Wehbi M, Freeman GJ, Lennox JL, Workowski KA, Hanson HL, Grakoui A. Radziewicz H, et al. Among authors: hon h. J Virol. 2008 Oct;82(20):9808-22. doi: 10.1128/JVI.01075-08. Epub 2008 Jul 30. J Virol. 2008. PMID: 18667503 Free PMC article.