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Coronavirus hemagglutinin-esterase and spike proteins coevolve for functional balance and optimal virion avidity.
Lang Y, Li W, Li Z, Koerhuis D, van den Burg ACS, Rozemuller E, Bosch BJ, van Kuppeveld FJM, Boons GJ, Huizinga EG, van der Schaar HM, de Groot RJ. Lang Y, et al. Among authors: huizinga eg. Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25759-25770. doi: 10.1073/pnas.2006299117. Epub 2020 Sep 29. Proc Natl Acad Sci U S A. 2020. PMID: 32994342 Free PMC article.
Human coronaviruses OC43 and HKU1 bind to 9-O-acetylated sialic acids via a conserved receptor-binding site in spike protein domain A.
Hulswit RJG, Lang Y, Bakkers MJG, Li W, Li Z, Schouten A, Ophorst B, van Kuppeveld FJM, Boons GJ, Bosch BJ, Huizinga EG, de Groot RJ. Hulswit RJG, et al. Among authors: huizinga eg. Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2681-2690. doi: 10.1073/pnas.1809667116. Epub 2019 Jan 24. Proc Natl Acad Sci U S A. 2019. PMID: 30679277 Free PMC article.
191 results