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The following term was not found in PubMed: 5C4.B8
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CS1003, a novel human and mouse cross-reactive PD-1 monoclonal antibody for cancer therapy.
Li F, Li J, Yin K, Zhang J, Li ZH, Lu L, Bao YW, Qin Z, Zheng Y, Yang BT, Li J, Wang X. Li F, et al. Acta Pharmacol Sin. 2021 Jan;42(1):142-148. doi: 10.1038/s41401-020-0422-6. Epub 2020 May 28. Acta Pharmacol Sin. 2021. PMID: 32467569 Free PMC article.
PD-1 antibodies can block the interaction of PD-1 with its ligands (PD-L1 and PD-L2), restore T cells activation, and elicit antitumor activity. ...We showed that CS1003 bound to recombinant human, cynomolgus monkey, and mouse P …
PD-1 antibodies can block the interaction of PD-1 with its ligands (PD-L1 and PD-L2), restore T cells activation …
Targeting the myeloid checkpoint receptor SIRPα potentiates innate and adaptive immune responses to promote anti-tumor activity.
Kuo TC, Chen A, Harrabi O, Sockolosky JT, Zhang A, Sangalang E, Doyle LV, Kauder SE, Fontaine D, Bollini S, Han B, Fu YX, Sim J, Pons J, Wan HI. Kuo TC, et al. J Hematol Oncol. 2020 Nov 30;13(1):160. doi: 10.1186/s13045-020-00989-w. J Hematol Oncol. 2020. PMID: 33256806 Free PMC article.
Here, we report the development of humanized AB21 (hAB21), a pan-allelic anti-SIRPalpha antibody that binds human, cynomolgus monkey, and mouse SIRPalpha alleles with high affinity and blocks the interaction with CD47. ...Immunophenotyping of tissues from MC3 …
Here, we report the development of humanized AB21 (hAB21), a pan-allelic anti-SIRPalpha antibody that binds human, cynomolgus …
COM902, a novel therapeutic antibody targeting TIGIT augments anti-tumor T cell function in combination with PVRIG or PD-1 pathway blockade.
Hansen K, Kumar S, Logronio K, Whelan S, Qurashi S, Cheng HY, Drake A, Tang M, Wall P, Bernados D, Leung L, Ophir E, Alteber Z, Cojocaru G, Galperin M, Frenkel M, White M, Hunter J, Liang SC, Kotturi MF. Hansen K, et al. Cancer Immunol Immunother. 2021 Dec;70(12):3525-3540. doi: 10.1007/s00262-021-02921-8. Epub 2021 Apr 26. Cancer Immunol Immunother. 2021. PMID: 33903974 Free PMC article.
We explored the therapeutic potential of targeting TIGIT by generating COM902, a fully human anti-TIGIT hinge-stabilized IgG4 monoclonal antibody that binds specifically to human, cynomolgus monkey, and mouse TIGIT, and disrupts the binding of TIGIT with PVR. …
We explored the therapeutic potential of targeting TIGIT by generating COM902, a fully human anti-TIGIT hinge-stabilized IgG4 monoclonal ant …