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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 1
1980 3
1981 3
1982 5
1983 8
1984 23
1985 11
1986 11
1987 13
1988 17
1989 15
1990 26
1991 33
1992 19
1993 33
1994 32
1995 38
1996 59
1997 62
1998 66
1999 66
2000 89
2001 71
2002 82
2003 65
2004 84
2005 84
2006 70
2007 81
2008 84
2009 80
2010 73
2011 85
2012 99
2013 79
2014 71
2015 59
2016 69
2017 80
2018 48
2019 59
2020 76
2021 76
2022 79
2023 93
2024 28

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2,201 results

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Page 1
Cholesterol and matrisome pathways dysregulated in astrocytes and microglia.
Tcw J, Qian L, Pipalia NH, Chao MJ, Liang SA, Shi Y, Jain BR, Bertelsen SE, Kapoor M, Marcora E, Sikora E, Andrews EJ, Martini AC, Karch CM, Head E, Holtzman DM, Zhang B, Wang M, Maxfield FR, Poon WW, Goate AM. Tcw J, et al. Cell. 2022 Jun 23;185(13):2213-2233.e25. doi: 10.1016/j.cell.2022.05.017. Cell. 2022. PMID: 35750033 Free PMC article.
The impact of apolipoprotein E epsilon4 (APOE4), the strongest genetic risk factor for Alzheimer's disease (AD), on human brain cellular function remains unclear. Here, we investigated the effects of APOE4 on brain cell types derived from population and isogenic …
The impact of apolipoprotein E epsilon4 (APOE4), the strongest genetic risk factor for Alzheimer's disease (AD), on human brai …
Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.
Wang C, Najm R, Xu Q, Jeong DE, Walker D, Balestra ME, Yoon SY, Yuan H, Li G, Miller ZA, Miller BL, Malloy MJ, Huang Y. Wang C, et al. Nat Med. 2018 May;24(5):647-657. doi: 10.1038/s41591-018-0004-z. Epub 2018 Apr 9. Nat Med. 2018. PMID: 29632371 Free PMC article.
Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a pressing need to study AD in human model systems. Using human neurons derived from induced pluripotent stem cells that expre …
Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting …
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia.
Sienski G, Narayan P, Bonner JM, Kory N, Boland S, Arczewska AA, Ralvenius WT, Akay L, Lockshin E, He L, Milo B, Graziosi A, Baru V, Lewis CA, Kellis M, Sabatini DM, Tsai LH, Lindquist S. Sienski G, et al. Sci Transl Med. 2021 Mar 3;13(583):eaaz4564. doi: 10.1126/scitranslmed.aaz4564. Sci Transl Med. 2021. PMID: 33658354 Free PMC article.
Here, we report that APOE4, but not APOE3, disrupted the cellular lipidomes of human induced pluripotent stem cell (iPSC)-derived astrocytes generated from fibroblasts of APOE4 or APOE3 carriers, and of yeast expressing human APOE isoforms. We combined lipidomics an …
Here, we report that APOE4, but not APOE3, disrupted the cellular lipidomes of human induced pluripotent stem cell (iPSC)-derived ast …
ApoE and Neurodegenerative Diseases in Aging.
Yin Y, Wang Z. Yin Y, et al. Adv Exp Med Biol. 2018;1086:77-92. doi: 10.1007/978-981-13-1117-8_5. Adv Exp Med Biol. 2018. PMID: 30232753 Review.
Age and apolipoprotein E (ApoE) are the mightiest risk factors for dementia and cardiovascular diseases, but the underlying mechanisms remain unclear. In human, ApoE has three isoforms, ApoE2, ApoE3, and ApoE4, which are expressed by the polymorphic alleles: e2, …
Age and apolipoprotein E (ApoE) are the mightiest risk factors for dementia and cardiovascular diseases, but the underlying mechanism …
Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity.
Victor MB, Leary N, Luna X, Meharena HS, Scannail AN, Bozzelli PL, Samaan G, Murdock MH, von Maydell D, Effenberger AH, Cerit O, Wen HL, Liu L, Welch G, Bonner M, Tsai LH. Victor MB, et al. Cell Stem Cell. 2022 Aug 4;29(8):1197-1212.e8. doi: 10.1016/j.stem.2022.07.005. Cell Stem Cell. 2022. PMID: 35931030 Free PMC article.
Apolipoprotein E4 (APOE4) is the greatest known genetic risk factor for developing sporadic Alzheimer's disease. ...
Apolipoprotein E4 (APOE4) is the greatest known genetic risk factor for developing sporadic Alzheimer's disease. ...
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.
Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV. Bell RD, et al. Nature. 2012 May 16;485(7399):512-6. doi: 10.1038/nature11087. Nature. 2012. PMID: 22622580 Free PMC article.
Human apolipoprotein E has three isoforms: APOE2, APOE3 and APOE4. ...
Human apolipoprotein E has three isoforms: APOE2, APOE3 and APOE4. ...
Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders.
Mahley RW. Mahley RW. J Mol Med (Berl). 2016 Jul;94(7):739-46. doi: 10.1007/s00109-016-1427-y. Epub 2016 Jun 9. J Mol Med (Berl). 2016. PMID: 27277824 Free PMC article. Review.
Apolipoprotein (apo) E was initially described as a lipid transport protein and major ligand for low density lipoprotein (LDL) receptors with a role in cholesterol metabolism and cardiovascular disease. ...
Apolipoprotein (apo) E was initially described as a lipid transport protein and major ligand for low density lipoprotein (LDL) recept …
APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge.
Lee S, Devanney NA, Golden LR, Smith CT, Schwartz JL, Walsh AE, Clarke HA, Goulding DS, Allenger EJ, Morillo-Segovia G, Friday CM, Gorman AA, Hawkinson TR, MacLean SM, Williams HC, Sun RC, Morganti JM, Johnson LA. Lee S, et al. Cell Rep. 2023 Mar 28;42(3):112196. doi: 10.1016/j.celrep.2023.112196. Epub 2023 Mar 3. Cell Rep. 2023. PMID: 36871219 Free PMC article.
The E4 allele of Apolipoprotein E (APOE) is associated with both metabolic dysfunction and a heightened pro-inflammatory response: two findings that may be intrinsically linked through the concept of immunometabolism. Here, we combined bulk, single-cell, and spatial transc …
The E4 allele of Apolipoprotein E (APOE) is associated with both metabolic dysfunction and a heightened pro-inflammatory response: tw …
APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases.
Fernández-Calle R, Konings SC, Frontiñán-Rubio J, García-Revilla J, Camprubí-Ferrer L, Svensson M, Martinson I, Boza-Serrano A, Venero JL, Nielsen HM, Gouras GK, Deierborg T. Fernández-Calle R, et al. Mol Neurodegener. 2022 Sep 24;17(1):62. doi: 10.1186/s13024-022-00566-4. Mol Neurodegener. 2022. PMID: 36153580 Free PMC article. Review.
ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of the most influential risk factors for the development of late-onset Alzheimer's disease (AD). ...
ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and apoE4, and t …
2,201 results