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Dihydrotanshinone I Enhances Cell Adhesion and Inhibits Cell Migration in Osteosarcoma U-2 OS Cells through CD44 and Chemokine Signaling.
Fan L, Peng C, Zhu X, Liang Y, Xu T, Xu P, Wu S. Fan L, et al. Molecules. 2022 Jun 9;27(12):3714. doi: 10.3390/molecules27123714. Molecules. 2022. PMID: 35744840 Free PMC article.
Thus, the increased expression of CD44 and lengthened protrusions around the cell yielded a significant increase in cell adhesion. In summary, these results suggest that dihydrotanshinone I might be an interesting molecular therapy for enhancing human osteosarcoma U …
Thus, the increased expression of CD44 and lengthened protrusions around the cell yielded a significant increase in cell adhesion. In …
Pentagalloylglucose suppresses the growth and migration of human nasopharyngeal cancer cells via the GSK3beta/beta-catenin pathway in vitro and in vivo.
Fan CW, Tang J, Jiang JC, Zhou MM, Li MS, Wang HS. Fan CW, et al. Phytomedicine. 2022 Jul 20;102:154192. doi: 10.1016/j.phymed.2022.154192. Epub 2022 May 21. Phytomedicine. 2022. PMID: 35636179
PGG regulated the cell cycle by altering p53, cyclin D1, CDK2, and cyclin E1 protein levels. PGG induced apoptosis and autophagy in NPC cells and elevated the Bax/Bcl-2 ratio and the protein levels of LC3B. Moreover, PGG decreased NPC cell migration by increasing E- …
PGG regulated the cell cycle by altering p53, cyclin D1, CDK2, and cyclin E1 protein levels. PGG induced apoptosis and autophagy in N …
Chemokine‑like receptor 1‑positive cells are present in the odontoblast layer in tooth tissue in rats and humans.
Yokokawa D, Umemura N, Miyamoto Y, Kondoh N, Kawano S. Yokokawa D, et al. Exp Ther Med. 2023 Dec 27;27(2):75. doi: 10.3892/etm.2023.12363. eCollection 2024 Feb. Exp Ther Med. 2023. PMID: 38264427 Free PMC article.
In addition, the localization of CD44 and CMKLR1 in human dental pulp stem cells was observed by immunofluorescence staining. ...CD44 was mainly localized in the cell membrane and CMKLR1 was mainly found in the cytoplasm of human dental pulp stem cells …
In addition, the localization of CD44 and CMKLR1 in human dental pulp stem cells was observed by immunofluorescence staining. …
Inhibition of the glycosylation and alteration in the intracellular trafficking of mucins and other glycoproteins by GalNAcalpha-O-bn in mucosal cell lines: an effect mediated through the intracellular synthesis of complex GalNAcalpha-O-bn oligosaccharides.
Gouyer V, Leteurtre E, Zanetta JP, Lesuffleur T, Delannoy P, Huet G. Gouyer V, et al. Front Biosci. 2001 Oct 1;6:D1235-44. doi: 10.2741/gouyer. Front Biosci. 2001. PMID: 11578961 Review.
To address the function of carbohydrates in mucins, GalNAcalpha-O-bn has been used in in vivo experiments on several human mucosal cultured cells as a potential competitor of the glycosylation of N-acetylgalactosamine residues. ...GalNAcalpha-O-bn treatment also induced al …
To address the function of carbohydrates in mucins, GalNAcalpha-O-bn has been used in in vivo experiments on several human mucosal cu …
Anti-Proliferation Effect of Theasaponin E1 on the ALDH-Positive Ovarian Cancer Stem-Like Cells.
Jia LY, Xia HL, Chen ZD, Compton C, Bucur H, Sawant DA, Rankin GO, Li B, Tu YY, Chen YC. Jia LY, et al. Molecules. 2018 Jun 17;23(6):1469. doi: 10.3390/molecules23061469. Molecules. 2018. PMID: 29914196 Free PMC article.
The ALDH+ cells showed significantly stronger sphere forming vitality and stronger cell migration capability. In addition, the stemness marker proteins CD44, Oct-4, Nanog, as well as Bcl-2 and MMP-9 expression levels of ALDH+ cells were upregulated compared with the …
The ALDH+ cells showed significantly stronger sphere forming vitality and stronger cell migration capability. In addition, the stemness mark …
Hyaluronan (HA)-inspired glycopolymers as molecular tools for studying HA functions.
Collis DWP, Yilmaz G, Yuan Y, Monaco A, Ochbaum G, Shi Y, O'Malley C, Uzunova V, Napier R, Bitton R, Becer CR, Azevedo HS. Collis DWP, et al. RSC Chem Biol. 2021 Jan 28;2(2):568-576. doi: 10.1039/d0cb00223b. eCollection 2021 Apr 1. RSC Chem Biol. 2021. PMID: 34458800 Free PMC article.
Hyaluronic acid (HA), the only non-sulphated glycosaminoglycan, serves numerous structural and biological functions in the human body, from providing viscoelasticity in tissues to creating hydrated environments for cell migration and proliferation. ...Using surface plasmon …
Hyaluronic acid (HA), the only non-sulphated glycosaminoglycan, serves numerous structural and biological functions in the human body …
Podoplanin is regulated by AP-1 and promotes platelet aggregation and cell migration in osteosarcoma.
Kunita A, Kashima TG, Ohazama A, Grigoriadis AE, Fukayama M. Kunita A, et al. Am J Pathol. 2011 Aug;179(2):1041-9. doi: 10.1016/j.ajpath.2011.04.027. Epub 2011 Jun 12. Am J Pathol. 2011. PMID: 21801875 Free PMC article.
Both podoplanin and TGF-beta1 were up-regulated by c-Fos induction in MC3T3-E1 osteoblastic cells, and were highly expressed in c-Fos transgenic mouse osteosarcomas and c-Fos-transformed osteosarcoma cell lines. ...Podoplanin was also expressed in osteosarcoma subtypes, wi …
Both podoplanin and TGF-beta1 were up-regulated by c-Fos induction in MC3T3-E1 osteoblastic cells, and were highly expressed in c-Fos …
Gli1, a potential regulator of esophageal cancer stem cell, is identified as an independent adverse prognostic factor in esophageal squamous cell carcinoma.
Yang Z, Cui Y, Ni W, Kim S, Xuan Y. Yang Z, et al. J Cancer Res Clin Oncol. 2017 Feb;143(2):243-254. doi: 10.1007/s00432-016-2273-6. Epub 2016 Sep 28. J Cancer Res Clin Oncol. 2017. PMID: 27680978
RESULTS: Gli1 expression was observed in 28.3 % of ESCC, and its expression was correlated with the expression of stemness genes, Sox9 (P = 0.003) and CD44 (P = 0.012). And Gli1, CD44, and Sox9 were highly expressed in more poorly differentiated ESCC cell lines such …
RESULTS: Gli1 expression was observed in 28.3 % of ESCC, and its expression was correlated with the expression of stemness genes, Sox9 (P = …
Role of Corneal Stromal Cells on Epithelial Cell Function during Wound Healing.
Kowtharapu BS, Murín R, Jünemann AGM, Stachs O. Kowtharapu BS, et al. Int J Mol Sci. 2018 Feb 4;19(2):464. doi: 10.3390/ijms19020464. Int J Mol Sci. 2018. PMID: 29401709 Free PMC article.
SP enriched the expression of integrin subunits alpha4, alpha5, alphaV, beta1 and beta3 whereas SFCM increased alpha4, alpha5, alphaV, beta1 and beta5 integrin subunits. We also observed increased expression of Serpin E1 following SP and SFCM treatment. Wound healing scrat …
SP enriched the expression of integrin subunits alpha4, alpha5, alphaV, beta1 and beta3 whereas SFCM increased alpha4, alpha5, alphaV, beta1 …
Establishment of an orthotopic transplantable gastric cancer animal model for studying the immunological effects of new cancer therapeutic modules.
Shan YS, Fang JH, Lai MD, Yen MC, Lin PW, Hsu HP, Lin CY, Chen YL. Shan YS, et al. Mol Carcinog. 2011 Oct;50(10):739-50. doi: 10.1002/mc.20668. Epub 2010 Aug 24. Mol Carcinog. 2011. PMID: 20737421
MGCC3I cells showed epithelial-like morphology, multinuclear giant cell formation, and retained an intestinal phenotype, which are similar to human gastric cancer carcinoma cells. The expression of gastric cancer markers MUC1, MUC2, and MUC5AC, and oncogenes c-myc, c-met, …
MGCC3I cells showed epithelial-like morphology, multinuclear giant cell formation, and retained an intestinal phenotype, which are similar t …
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