Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 2
2000 1
2001 1
2006 1
2008 1
2009 3
2010 2
2012 2
2013 4
2014 4
2015 5
2016 3
2017 5
2018 9
2019 7
2020 13
2021 8
2022 10
2023 10
2024 1

Text availability

Article attribute

Article type

Publication date

Search Results

83 results

Results by year

Filters applied: . Clear all
Page 1
NLRP3/caspase-1/GSDMD-mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression.
Li S, Sun Y, Song M, Song Y, Fang Y, Zhang Q, Li X, Song N, Ding J, Lu M, Hu G. Li S, et al. JCI Insight. 2021 Dec 8;6(23):e146852. doi: 10.1172/jci.insight.146852. JCI Insight. 2021. PMID: 34877938 Free PMC article.
Here, we observed that depressive mice showed astrocytic pyroptosis, which was responsible for astrocyte loss, and selective serotonin reuptake inhibitor (SSRI) treatment could attenuate the pyroptosis induced by the chronic mild stress (CMS) model. Genetic KO of GSDMD, Casp …
Here, we observed that depressive mice showed astrocytic pyroptosis, which was responsible for astrocyte loss, and selective serotonin reupt …
Caspase-1 transcripts in failing human heart after mechanical unloading.
Prescimone T, D'Amico A, Caselli C, Cabiati M, Viglione F, Caruso R, Verde A, Del Ry S, Trivella MG, Giannessi D. Prescimone T, et al. Cardiovasc Pathol. 2015 Jan-Feb;24(1):11-8. doi: 10.1016/j.carpath.2014.08.002. Epub 2014 Aug 12. Cardiovasc Pathol. 2015. PMID: 25200478
CONCLUSIONS: This study describes a specific pattern of the Casp-1 system associated with inflammation and apoptosis markers in patients who require LVAD insertion. The inflammation could be the key process regulating, in a negative loop, Casp-1 signal …
CONCLUSIONS: This study describes a specific pattern of the Casp-1 system associated with inflammation and apoptosis markers i …
CASP-1, -2 and -5 gene polymorphisms and cancer risk: A review and meta-analysis.
Pan YL, Liu W, Gao CX, Shang Z, Ning LJ, Liu X. Pan YL, et al. Biomed Rep. 2013 Jul;1(4):511-516. doi: 10.3892/br.2013.98. Epub 2013 Apr 25. Biomed Rep. 2013. PMID: 24648977 Free PMC article.
These genetic polymorphisms have been extensively investigated as a potential risk factor for cancer, but results have been inconclusive. This Human Genome Epidemiology (HuGE) review and meta-analysis was performed to investigate the associations between CASP-1 …
These genetic polymorphisms have been extensively investigated as a potential risk factor for cancer, but results have been inconclusive. Th …
HIV-1 Gag and Vpr impair the inflammasome activation and contribute to the establishment of chronic infection in human primary macrophages.
Galvão-Lima LJ, Zambuzi FA, Soares LS, Fontanari C, Meireles AFG, Brauer VS, Faccioli LH, Gama L, Figueiredo LTM, Bou-Habib DC, Frantz FG. Galvão-Lima LJ, et al. Mol Immunol. 2022 Aug;148:68-80. doi: 10.1016/j.molimm.2022.04.018. Epub 2022 Jun 2. Mol Immunol. 2022. PMID: 35659727
In this sense, we aimed to evaluate the viral and cellular mechanisms activated during HIV-1 infection in human primary macrophages that allow an effective viral replication in these cells. We found that resting HIV-1-infected macrophages, but not those activated in classi …
In this sense, we aimed to evaluate the viral and cellular mechanisms activated during HIV-1 infection in human primary macrophages t …
Cathepsin B/NLRP3/GSDMD axis-mediated macrophage pyroptosis induces inflammation and fibrosis in systemic sclerosis.
Liu C, Tang J, Liu S, Shen C, Zhou X, Lu J, Li M, Zhu L. Liu C, et al. J Dermatol Sci. 2022 Dec;108(3):127-137. doi: 10.1016/j.jdermsci.2022.12.006. Epub 2022 Dec 24. J Dermatol Sci. 2022. PMID: 36585288
The levels of pyroptosis markers, dermal thickness and collagen deposition in skin were assessed before and after the administration of pyroptosis inhibitors, including MCC950, Disulfiram and necrosulfonamide (NSA). Human-derived monocyte-macrophage cell line (THP-1) or mo …
The levels of pyroptosis markers, dermal thickness and collagen deposition in skin were assessed before and after the administration of pyro …
Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor.
Beyaert R, Kidd VJ, Cornelis S, Van de Craen M, Denecker G, Lahti JM, Gururajan R, Vandenabeele P, Fiers W. Beyaert R, et al. J Biol Chem. 1997 May 2;272(18):11694-7. doi: 10.1074/jbc.272.18.11694. J Biol Chem. 1997. PMID: 9115219 Free article.
Testing of seven murine CASPs for their ability to cleave p110 PITSLRE kinase alpha2-1 in vitro revealed that only CASP-1 (ICE (interleukin-1beta-converting enzyme)) and CASP-3 (CPP32) were able to produce the same 43-kDa cleavage product as observed in cells underg …
Testing of seven murine CASPs for their ability to cleave p110 PITSLRE kinase alpha2-1 in vitro revealed that only CASP-1 (ICE …
A literature-based systematic HuGE review and meta-analysis show that CASP gene family polymorphisms are associated with risk of lung cancer.
Zhang ZY, Xuan Y, Jin XY, Tian X, Wu R. Zhang ZY, et al. Genet Mol Res. 2013 Jan 4;12(3):3057-69. doi: 10.4238/2013.January.4.22. Genet Mol Res. 2013. PMID: 23315881 Free article. Review.
However, this specific association is still controversial. In this Human Genome Epidemiology review and meta-analysis, we summarized the available evidence associating lung cancer with the CASP gene family. ...In seven studies, 19 different SNPs have been studied in seven …
However, this specific association is still controversial. In this Human Genome Epidemiology review and meta-analysis, we summarized …
Aspulvins A-H, Aspulvinone Analogues with SARS-CoV-2 Mpro Inhibitory and Anti-inflammatory Activities from an Endophytic Cladosporium sp.
Liang XX, Zhang XJ, Zhao YX, Feng J, Zeng JC, Shi QQ, Kaunda JS, Li XL, Wang WG, Xiao WL. Liang XX, et al. J Nat Prod. 2022 Apr 22;85(4):878-887. doi: 10.1021/acs.jnatprod.1c01003. Epub 2022 Mar 16. J Nat Prod. 2022. PMID: 35293744 Review.
Compound 10 showed the most potent anti-inflammatory activity by inhibiting Casp-1 cleavage, IL-1beta maturation, NLRP3 inflammasome activation, and pyroptosis. ...
Compound 10 showed the most potent anti-inflammatory activity by inhibiting Casp-1 cleavage, IL-1beta maturation, NLRP3 inflam …
High-Dose Vitamin B6 (Pyridoxine) Displays Strong Anti-Inflammatory Properties in Lipopolysaccharide-Stimulated Monocytes.
Mikkelsen K, Dargahi N, Fraser S, Apostolopoulos V. Mikkelsen K, et al. Biomedicines. 2023 Sep 19;11(9):2578. doi: 10.3390/biomedicines11092578. Biomedicines. 2023. PMID: 37761018 Free PMC article.
This study set out to examine the effects of high-dose vitamin B6 on an LPS-stimulated monocyte/macrophage cell population via an analysis of protein and gene expression using an RT2 profiler PCR array for Human Innate and Adaptive Immune responses. It was identified that …
This study set out to examine the effects of high-dose vitamin B6 on an LPS-stimulated monocyte/macrophage cell population via an analysis o …
Apoptosis as a common bacterial virulence strategy.
Monack D, Falkow S. Monack D, et al. Int J Med Microbiol. 2000 Mar;290(1):7-13. doi: 10.1016/S1438-4221(00)80096-X. Int J Med Microbiol. 2000. PMID: 11043977 Review.
Yersinia induces apoptosis by inhibiting the translocation of the transcriptional activator, NF-kappaB, into the nucleus, which results in the suppression of TNFalpha production; whereas Salmonella- and Shigella-induced apoptosis depend on the activation of caspase-1 (casp …
Yersinia induces apoptosis by inhibiting the translocation of the transcriptional activator, NF-kappaB, into the nucleus, which results in t …
83 results