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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1984 1
1994 1
1995 4
1996 10
1997 14
1998 16
1999 28
2000 41
2001 41
2002 32
2003 47
2004 46
2005 64
2006 66
2007 57
2008 90
2009 83
2010 93
2011 100
2012 96
2013 120
2014 115
2015 135
2016 112
2017 130
2018 129
2019 102
2020 103
2021 119
2022 80
2023 64
2024 26

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1,896 results

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Page 1
Human cathepsin X/Z is a biologically active homodimer.
Dolenc I, Štefe I, Turk D, Taler-Verčič A, Turk B, Turk V, Stoka V. Dolenc I, et al. Biochim Biophys Acta Proteins Proteom. 2021 Feb;1869(2):140567. doi: 10.1016/j.bbapap.2020.140567. Epub 2020 Nov 20. Biochim Biophys Acta Proteins Proteom. 2021. PMID: 33227497
Human cathepsin X belongs to the cathepsin family of 11 lysosomal cysteine proteases. ...The novel finding that cathepsin X is a dimeric protein opens new horizons in the understanding of its function and the underlying pathophysiological mechanisms of various diseases inc …
Human cathepsin X belongs to the cathepsin family of 11 lysosomal cysteine proteases. ...The novel finding that cathepsin X is a dime …
Discovery of a periosteal stem cell mediating intramembranous bone formation.
Debnath S, Yallowitz AR, McCormick J, Lalani S, Zhang T, Xu R, Li N, Liu Y, Yang YS, Eiseman M, Shim JH, Hameed M, Healey JH, Bostrom MP, Landau DA, Greenblatt MB. Debnath S, et al. Nature. 2018 Oct;562(7725):133-139. doi: 10.1038/s41586-018-0554-8. Epub 2018 Sep 24. Nature. 2018. PMID: 30250253 Free PMC article.
Genetic blockade of the ability of PSCs to give rise to bone-forming osteoblasts results in selective impairments in cortical bone architecture and defects in fracture healing. A cell analogous to mouse PSCs is present in the human periosteum, raising the possibility that …
Genetic blockade of the ability of PSCs to give rise to bone-forming osteoblasts results in selective impairments in cortical bone architect …
Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues.
Velasco G, Ferrando AA, Puente XS, Sánchez LM, López-Otín C. Velasco G, et al. J Biol Chem. 1994 Oct 28;269(43):27136-42. J Biol Chem. 1994. PMID: 7929457 Free article.
Cathepsin O proteolytic activity was abolished by trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane (E-64), an inhibitor of this subclass of proteolytic enzymes, thus providing additional evidence that the isolated cDNA codes for an authentic cysteine proteinase …
Cathepsin O proteolytic activity was abolished by trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane (E-64), an inhibitor o …
Human cathepsin L, a papain-like collagenase without proline specificity.
Korenč M, Lenarčič B, Novinec M. Korenč M, et al. FEBS J. 2015 Nov;282(22):4328-40. doi: 10.1111/febs.13499. Epub 2015 Sep 12. FEBS J. 2015. PMID: 26306868 Free article.
A common denominator of these peptidases is their ability to cleave substrates with Pro in the P2 position. In humans, cathepsin K is the best-known papain-like collagenase. Here, we investigate the collagenolytic activity of human cathepsin L, which i …
A common denominator of these peptidases is their ability to cleave substrates with Pro in the P2 position. In humans, cathepsin …
PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis.
Xie H, Cui Z, Wang L, Xia Z, Hu Y, Xian L, Li C, Xie L, Crane J, Wan M, Zhen G, Bian Q, Yu B, Chang W, Qiu T, Pickarski M, Duong LT, Windle JJ, Luo X, Liao E, Cao X. Xie H, et al. Nat Med. 2014 Nov;20(11):1270-8. doi: 10.1038/nm.3668. Epub 2014 Oct 5. Nat Med. 2014. PMID: 25282358 Free PMC article.
In the ovariectomy (OVX)-induced osteoporotic mouse model, serum and bone marrow levels of PDGF-BB and numbers of CD31(hi)Emcn(hi) vessels are significantly lower compared to sham-operated controls. Treatment with exogenous PDGF-BB or inhibition of cathepsin K to in …
In the ovariectomy (OVX)-induced osteoporotic mouse model, serum and bone marrow levels of PDGF-BB and numbers of CD31(hi)Emcn(hi) vessels a …
Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2.
Shi GP, Chapman HA, Bhairi SM, DeLeeuw C, Reddy VY, Weiss SJ. Shi GP, et al. FEBS Lett. 1995 Jan 3;357(2):129-34. doi: 10.1016/0014-5793(94)01349-6. FEBS Lett. 1995. PMID: 7805878 Free article.
Based on its high homology to OC2, we have named the human enzyme cathepsin O. Cathepsin O mRNA was identified as a single approximately 1.7 kb transcript in cultures of 15-day-old monocyte-derived macrophages, but was not expressed in human …
Based on its high homology to OC2, we have named the human enzyme cathepsin O. Cathepsin O mRNA was ident …
Human osteoclastogenesis in Epstein-Barr virus-induced erosive arthritis in humanized NOD/Shi-scid/IL-2Rgammanull mice.
Nagasawa Y, Takei M, Iwata M, Nagatsuka Y, Tsuzuki H, Imai K, Imadome KI, Fujiwara S, Kitamura N. Nagasawa Y, et al. PLoS One. 2021 Apr 1;16(4):e0249340. doi: 10.1371/journal.pone.0249340. eCollection 2021. PLoS One. 2021. PMID: 33793647 Free PMC article.
Multinucleated cells observed during bone erosion stained positively for human cathepsin K and MMP-9. These results indicate that human osteoclasts primarily induce erosive arthritis during EBV infections. ...Multinucleated cells cultured from the bone …
Multinucleated cells observed during bone erosion stained positively for human cathepsin K and MMP-9. These results ind …
Cathepsin K osteoporosis trials, pycnodysostosis and mouse deficiency models: Commonalities and differences.
Brömme D, Panwar P, Turan S. Brömme D, et al. Expert Opin Drug Discov. 2016;11(5):457-72. doi: 10.1517/17460441.2016.1160884. Epub 2016 Mar 22. Expert Opin Drug Discov. 2016. PMID: 27001692 Review.
AREAS COVERED: This review analyses the current status of cathepsin K inhibitor development, its side effects, and compares the phenotypes of mouse and human cathepsin K deficiencies with drug treatment outcomes. EXPERT OPINION: Several selectiv …
AREAS COVERED: This review analyses the current status of cathepsin K inhibitor development, its side effects, and compares th …
Interstitial collagen catabolism.
Fields GB. Fields GB. J Biol Chem. 2013 Mar 29;288(13):8785-93. doi: 10.1074/jbc.R113.451211. Epub 2013 Feb 19. J Biol Chem. 2013. PMID: 23430258 Free PMC article. Review.
Mammalian collagenolytic enzymes include matrix metalloproteinases, cathepsin K, and neutrophil elastase, and a variety of invertebrates and pathogens possess collagenolytic enzymes. ...
Mammalian collagenolytic enzymes include matrix metalloproteinases, cathepsin K, and neutrophil elastase, and a variety of inv …
1,896 results