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Adiponectin and its globular fragment differentially modulate the oxidative burst of primary human phagocytes.
Chedid P, Hurtado-Nedelec M, Marion-Gaber B, Bournier O, Hayem G, Gougerot-Pocidalo MA, Frystyk J, Flyvbjerg A, El Benna J, Marie JC. Chedid P, et al. Am J Pathol. 2012 Feb;180(2):682-92. doi: 10.1016/j.ajpath.2011.10.013. Epub 2011 Nov 23. Am J Pathol. 2012. PMID: 22119038
Acrp30 inhibited fMLF-induced ROS production by human phagocytes, whereas gAcrp30 enhanced it. gAcrp30's effect is additive with TNFalpha, whereas Acrp30 inhibited TNFalpha-induced priming. gAcrp30 enhanced NOX-2 expression at the plasma membrane, with …
Acrp30 inhibited fMLF-induced ROS production by human phagocytes, whereas gAcrp30 enhanced it. gAcrp30's effect is addi …
Autocrine action of adiponectin on human fat cells prevents the release of insulin resistance-inducing factors.
Dietze-Schroeder D, Sell H, Uhlig M, Koenen M, Eckel J. Dietze-Schroeder D, et al. Diabetes. 2005 Jul;54(7):2003-11. doi: 10.2337/diabetes.54.7.2003. Diabetes. 2005. PMID: 15983200
The adipocyte hormone adiponectin is negatively correlated with obesity and insulin resistance and may exert an important antidiabetes function. In this study, primary human skeletal muscle cells were cocultured with human fat cells or incubated with adipocyte-condi …
The adipocyte hormone adiponectin is negatively correlated with obesity and insulin resistance and may exert an important antidiabetes funct …
The stimulatory effect of globular adiponectin on insulin-stimulated glucose uptake and fatty acid oxidation is impaired in skeletal muscle from obese subjects.
Bruce CR, Mertz VA, Heigenhauser GJ, Dyck DJ. Bruce CR, et al. Diabetes. 2005 Nov;54(11):3154-60. doi: 10.2337/diabetes.54.11.3154. Diabetes. 2005. PMID: 16249439
However, little is known regarding the effect of adiponectin on metabolism in human skeletal muscle. Therefore, we examined whether the globular head of adiponectin, gAcrp30, acutely activates fatty acid oxidation and glucose uptake in isolated human skeletal …
However, little is known regarding the effect of adiponectin on metabolism in human skeletal muscle. Therefore, we examined whether t …
Transcriptomic analysis of MA-10 tumor Leydig cells treated with adipose derived hormones adiponectin and resistin.
Nguyen HT, Martin LJ. Nguyen HT, et al. Reprod Biol. 2022 Mar;22(1):100598. doi: 10.1016/j.repbio.2021.100598. Epub 2021 Dec 17. Reprod Biol. 2022. PMID: 34929619
Interestingly, genes upregulated by the globular form of adiponectin (gACRP30) were associated to steroid hormones biosynthesis, whereas resistin had no effect on the transcriptome of MA-10 Leydig cells. ...
Interestingly, genes upregulated by the globular form of adiponectin (gACRP30) were associated to steroid hormones biosynthesis, wher …
Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice.
Fruebis J, Tsao TS, Javorschi S, Ebbets-Reed D, Erickson MR, Yen FT, Bihain BE, Lodish HF. Fruebis J, et al. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):2005-10. doi: 10.1073/pnas.98.4.2005. Epub 2001 Feb 6. Proc Natl Acad Sci U S A. 2001. PMID: 11172066 Free PMC article.
Adipocyte complement-related protein (30 kDa) (Acrp30), a secreted protein of unknown function, is exclusively expressed in differentiated adipocytes; its mRNA is decreased in obese humans and mice. Here we describe novel pharmacological properties of the protease-generate …
Adipocyte complement-related protein (30 kDa) (Acrp30), a secreted protein of unknown function, is exclusively expressed in differentiated a …
Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30).
Tsao TS, Murrey HE, Hug C, Lee DH, Lodish HF. Tsao TS, et al. J Biol Chem. 2002 Aug 16;277(33):29359-62. doi: 10.1074/jbc.C200312200. Epub 2002 Jun 26. J Biol Chem. 2002. PMID: 12087086 Free article.
Here we have used several approaches to show that Acrp30 expressed in and purified from Escherichia coli and human embryonic kidney 293T cells forms trimers and hexamers; 293T cells also produce a higher molecular weight species. ...Importantly, only hexameric and larger i …
Here we have used several approaches to show that Acrp30 expressed in and purified from Escherichia coli and human embryonic kidney 2 …
Cloning and expression of adiponectin and its globular domain, and measurement of the biological activity in vivo.
Hu XB, Zhang YJ, Zhang HT, Yang SL, Gong Y. Hu XB, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003 Nov;35(11):1023-8. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003. PMID: 14614541 Free article.
Decreased expression of ACRP30 correlates with insulin resistance in mouse models of altered insulin sensitivity. Adiponectin, the human homologue of ACRP30, circulates in human plasma at high levels. ...Here, full-length adiponectin and its C-terminal globular head …
Decreased expression of ACRP30 correlates with insulin resistance in mouse models of altered insulin sensitivity. Adiponectin, the human …