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1994 3
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286 results

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Page 1
The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth.
Sandovici I, Georgopoulou A, Pérez-García V, Hufnagel A, López-Tello J, Lam BYH, Schiefer SN, Gaudreau C, Santos F, Hoelle K, Yeo GSH, Burling K, Reiterer M, Fowden AL, Burton GJ, Branco CM, Sferruzzi-Perri AN, Constância M. Sandovici I, et al. Dev Cell. 2022 Jan 10;57(1):63-79.e8. doi: 10.1016/j.devcel.2021.12.005. Epub 2021 Dec 27. Dev Cell. 2022. PMID: 34963058 Free PMC article.
The angiocrine effects of IGF2 on placental microvasculature expansion are mediated, in part, through IGF2R and angiopoietin-Tie2/TEK signaling. Additionally, IGF2 exerts IGF2R-ERK1/2-dependent pro-proliferative and angiogenic effects on primary feto-placental endot …
The angiocrine effects of IGF2 on placental microvasculature expansion are mediated, in part, through IGF2R and angiopoietin-Tie2/TEK …
Icariside II suppresses the tumorigenesis and development of ovarian cancer by regulating miR-144-3p/IGF2R axis.
Yuan D, Guo T, Qian H, Ge H, Zhao Y, Huang A, Wang X, Cao X, Zhu D, He C, Yu H. Yuan D, et al. Drug Dev Res. 2022 Sep;83(6):1383-1393. doi: 10.1002/ddr.21967. Epub 2022 Jul 9. Drug Dev Res. 2022. PMID: 35808943
Moreover, IGF2R was targeted by miR-144-3p directly. Icariside II significantly decreased the expression of IGF2R and the phosphorylation level of AKT and mTOR in ovarian cancer cells, which were partially reversed by miR-144-3p inhibitor. ...Collectively, Ic …
Moreover, IGF2R was targeted by miR-144-3p directly. Icariside II significantly decreased the expression of IGF2R and the phos …
Proteomics analysis of cancer tissues identifies IGF2R as a potential therapeutic target in laryngeal carcinoma.
Liu B, Hu Y, Wan L, Wang L, Cheng L, Sun H, Liu Y, Wu D, Zhu J, Hong X, Li Y, Zhou C. Liu B, et al. Front Endocrinol (Lausanne). 2022 Oct 10;13:1031210. doi: 10.3389/fendo.2022.1031210. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36299463 Free PMC article.
Due to the perduring scarcity of effective targeted drugs for laryngeal cancer, insights into the disease's pathophysiological mechanisms would substantially impact the treatment landscape of laryngeal cancer. ...Nonsense-mediated RNA decay (NMD), RNA translation, a …
Due to the perduring scarcity of effective targeted drugs for laryngeal cancer, insights into the disease's pathophysiological mechan …
Loss of IGF2R indicates a poor prognosis and promotes cell proliferation and tumorigenesis in bladder cancer via AKT signaling pathway.
Liu SB, Zhou LB, Wang HF, Li G, Xie QP, Hu B. Liu SB, et al. Neoplasma. 2020 Jan;67(1):129-136. doi: 10.4149/neo_2019_190206N108. Epub 2019 Dec 17. Neoplasma. 2020. PMID: 31847523
However, its role in bladder cancer is unknown. In the current study, we reported that IGF2R expression was decreased in bladder cancer tissues (p<0.05). ...Moreover, silencing IGF2R promoted cell proliferation of bladder cancer cells in vitr …
However, its role in bladder cancer is unknown. In the current study, we reported that IGF2R expression was decreased in bladd …
Upregulation of IGF2R evades lysosomal dysfunction-induced apoptosis of cervical cancer cells via transport of cathepsins.
Takeda T, Komatsu M, Chiwaki F, Komatsuzaki R, Nakamura K, Tsuji K, Kobayashi Y, Tominaga E, Ono M, Banno K, Aoki D, Sasaki H. Takeda T, et al. Cell Death Dis. 2019 Nov 20;10(12):876. doi: 10.1038/s41419-019-2117-9. Cell Death Dis. 2019. PMID: 31748500 Free PMC article.
Here, on the basis of transcriptome analysis of TCGA and GEO open datasets, we show that IGF2R is upregulated and correlated with poor prognosis in cervical cancer. ...Taken together, IGF2R has an oncogenic role through transportation of M6P-tagged cargo in c …
Here, on the basis of transcriptome analysis of TCGA and GEO open datasets, we show that IGF2R is upregulated and correlated with poo …
The miR-4306/IGF2R axis modulates the lung adenocarcinoma response to irradiation in vitro and in vivo.
Liu L, He L, Li W, Zhao T, Li G, Xiu X, Xu Y, Bourbonne V, Käsmann L, Kowalchuk RO, Zhong Q. Liu L, et al. Transl Lung Cancer Res. 2021 Dec;10(12):4494-4510. doi: 10.21037/tlcr-21-890. Transl Lung Cancer Res. 2021. PMID: 35070756 Free PMC article.
The effects of miR-4306 overexpression were partially attenuated by IGF2R overexpression. In lung adenocarcinoma cells, suppressive role of irradiation on cancer cell viability and invasive abilities were enhanced by IGF2R overexpression, but attenuated by …
The effects of miR-4306 overexpression were partially attenuated by IGF2R overexpression. In lung adenocarcinoma cells, suppressive r …
RAB21 controls autophagy and cellular energy homeostasis by regulating retromer-mediated recycling of SLC2A1/GLUT1.
Pei Y, Lv S, Shi Y, Jia J, Ma M, Han H, Zhang R, Tan J, Zhang X. Pei Y, et al. Autophagy. 2023 Apr;19(4):1070-1086. doi: 10.1080/15548627.2022.2114271. Epub 2022 Aug 21. Autophagy. 2023. PMID: 35993307 Free PMC article.
Functionally, RAB21 depletion sensitizes cancer cells to energy stress and inhibits tumor growth in vivo, suggesting an oncogenic role for RAB21. Overall, our study illuminates the role of RAB21 in regulating endosomal dynamics and maintaining cellular energy homeostasis a …
Functionally, RAB21 depletion sensitizes cancer cells to energy stress and inhibits tumor growth in vivo, suggesting an oncogenic rol …
Autophagy-associated circular RNA hsa_circ_0007813 modulates human bladder cancer progression via hsa-miR-361-3p/IGF2R regulation.
Zhang Z, Mou Z, Xu C, Wu S, Dai X, Chen X, Ou Y, Chen Y, Yang C, Jiang H. Zhang Z, et al. Cell Death Dis. 2021 Aug 7;12(8):778. doi: 10.1038/s41419-021-04053-4. Cell Death Dis. 2021. PMID: 34365465 Free PMC article.
We then found that knockdown of hsa_circ_0007813 led to altered cell autophagy, bringing our attention to IGF2R, one of the possible downstream genes. IGF2R was also known as cation-independent mannose-6-phosphate receptor (CI-M6PR), was discovered to participate in …
We then found that knockdown of hsa_circ_0007813 led to altered cell autophagy, bringing our attention to IGF2R, one of the possible …
IGF2R genetic variants, circulating IGF2 concentrations and colon cancer risk in African Americans and Whites.
Hoyo C, Murphy SK, Schildkraut JM, Vidal AC, Skaar D, Millikan RC, Galanko J, Sandler RS, Jirtle R, Keku T. Hoyo C, et al. Dis Markers. 2012;32(2):133-41. doi: 10.3233/DMA-2011-0865. Dis Markers. 2012. PMID: 22377707 Free PMC article.
We evaluated the associations between IGF2R non-synonymous genetic variants (c.5002G>A, Gly1619Arg(rs629849), and c.901C>G, Leu252Val(rs8191754)), circulating IGF2 levels, and colon cancer (CC) risk among African American and White participants enrolled in the …
We evaluated the associations between IGF2R non-synonymous genetic variants (c.5002G>A, Gly1619Arg(rs629849), and c.901C>G, Leu …
Interactions of IGF-II with the IGF2R/cation-independent mannose-6-phosphate receptor mechanism and biological outcomes.
Brown J, Jones EY, Forbes BE. Brown J, et al. Vitam Horm. 2009;80:699-719. doi: 10.1016/S0083-6729(08)00625-0. Vitam Horm. 2009. PMID: 19251056 Review.
As this ligand is important for cell growth, survival, and migration, the maintenance of correct IGF-II levels influences its actions in normal growth and development. Deregulation of IGF2R expression has therefore been associated with growth related disease and cancer …
As this ligand is important for cell growth, survival, and migration, the maintenance of correct IGF-II levels influences its actions in nor …
286 results